The Pharmacology and Molecular Biology of Large-Conductance Calcium = Activated (BK) Potassium Channels

Advances in Pharmacology

Volumn 37, Issue C, 1996, Pages 319-348

  Gribkoff, Valentin K ^a   Starrett Jr , John E ^a   Dworetzky, Steven I ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0009646906     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60954-0     Document Type: Article

References (125)

1. Adelman J.P., Shen K.-Z., Kavanaugh M.P., Warren R.A., Wu Y.-N., Lagrutta A., Bond C.T., and North R.A. Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron 9 (1992) 209-216
2. Anderson C.S., MacKinnon R., Smith C., and Miller C. Charybdotoxin block of single Caz7-activated K+ channels: Effects of channel gating, voltage, and ionic strength. J. Gen. Physiol. 91 (1988) 317-333
3. Armstrong C. Voltage-dependent ion channels and their gating. Physiol. Rev. 72 (1992) S5-S13
4. + channels regulate myogenic tone in the resting state of arteries from spontaneously hypertensive rats. Br. J. Pharmacol. 108 (1993) 214-222
5. + channels in the resting state of cerebral, coronary and mesenteric arteries of the dog. J. Pharmacol. Exp. Ther. 267 (1993) 1277-1285
6. + channels in the resting state of dog basilar artery. J. Auton. New. Syst. 49 (1994) S151-S155
7. + channels in resting state of femoral arteries from spontaneously hypertensive rats at prehypertensive stage. J. Pharmacol. Exp. Ther. 275 (1995) 775-783
8. Atkinson N.S., Robertson G.A., and Ganetzky B. A component of calcium-activated potassium channels encoded by Drosophila Slo locus. Science (Wash.) 253 (1991) 551-555
9. Augustine G.J., and Eckert R. Calcium-dependent potassium current in squid presyn-aptic nerve terminals. Biol. Bull. 163 (1982) 397
10. Barrett J.N., Barrett E.F., and Dribin L.B. Calcium-dependent slow potassium conductance in rat skeletal myotubes. Dev. Biol. 82 (1981) 258-266
11. Barrett J.N., Magleby K.L., and Pallotta B.S. Properties of single calcium activated potassium channels in cultured rat muscle. J. Physiol. (Lond.) 331 (1982) 211-230
12. Benham C.D., Bolton T.B., Lang R.J., and Takewaki T. Calcium-activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea-pig rnesenteric artery. J. Physiol. (Lond.) 371 (1986) 45-67
13. Bielefeldt K., and Jackson M. A calcium-activated potassium channel causes frequency-dependent action-potential failures in a mammalian nerve terminal. J. Neurophysiol. 70 (1993) 284-298
14. Blatz A., and Magleby K. Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle. J. Gen. Physiol. 84 (1984) 1-23
15. + channels of small conductance in cultured rat skeletal muscle. Nature (Lond.) 323 (1986) 718-720
16. Bliss T.V.P., and Collingridge G.L. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature (Lond.) 361 (1993) 31-39
17. Brayden J.E., and Nelson M.T. Regulation of arterial tone by activation of calcium-dependent potassium channels. Science (Wash.) 256 (1992) 532-535
18. Butler A., Tsunoda S., McCobb D.P., Wei A., and Salkoff L. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science (Wash.) 261 (1993) 221-224
19. + channel. Biophys. J. 63 (1992) 583-590
20. Capoid T., and Ogden D. The properties of calcium-activated potassium channels in guinea pig isolated hepatocytes. J. Physiol. (Lond.) 409 (1989) 285-295
21. + channels in canine colon. Pflugers Arch. 421 (1992) 67-76
22. Chandy K.G., and Gutman G.A. Voltage-gated potassium channel genes. In: North R.A. (Ed). "Handbook of Receptors and Channels: Ligand- and Voltage-Gated Ion Channels" (1995), CRC Press, Boca Raton, FL. 1-71
23. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1 (1988) 623-634
24. Chung S., Reinhart P.H., Martin B.L., Brautigan D.L., and Levitan I.B. Protein kinase activity closely associated with a reconstituted calcium-activated potassium channel. Science (Wash.) 253 (1991) 560-562
25. Cook S.J., Archer K., Martin M., Buchheit K.H., Fozard J.R., Muller T., Miller A.J., Elliot K.R.F., Foster R.W., and Small R.C. Further analysis of the mechanisms underlying the tracheal relaxant action of SCA-40. Br. J. Pharmacol. 114 (1995) 143-151
26. Delmas P., and Gola M. Choline blocks large conductance Kca channels in mammalian sympathetic neurones. Neurosci. Lett. 189 (1995) 109-112
27. 3 cells. Brain Res. 638 (1994) 61-68
28. + channels. J. Physiol. (Lond.) 489 (1995) 403-418
29. Dworetzky S.I., Trojnacki J.T., and Gribkoff V.K. Cloning and expression of a human large-conductance calcium-activated potassium channel. Mol. Brain Res. 27 (1994) 189-193
30. ca channel opener, in vascular smooth muscle. Br. J. Pharmacol. 113 (1994) 1538-1547
31. + channels in red cells by selected dihydropyridine derivatives. Br. J. Pharmacol. 111 (1994) 903-905
32. + channel modulated by a functionally associated protein kinase. Nature (Lond.) 369 (1994) 563-565
33. + channels of large conductance in rat brain synaptosomal membranes. Biophys. J. 53 (1988) 919-934
34. + channels and suppression of neuronal activity by secreted β-amyloid precursor protein. Nature (Lond.) 379 (1996) 74-78
35. Galvez A., Giminez-Gallago G., Reuben J.P., Roy-Constancin L., Feigenbaum P., Kaczorowski G.J., and Garcia M.L. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulusm. J. Bid. Chem. 265 (1990) 11083-11090
36. Garcia, M. L., Giacobbe, R. A., Hensens, O. D., Lee, S. H., and McManus, O. B. (1995a). Indole diterpene alkaloid compounds. International Patent Application WO 95/19771
37. Garcia M.L., Knaus H.-G., Munujos P., Slaughter R.S., and Kaczorowski G.J. Charybdotoxin and its effects on potassium channels. Am. J. Physiol. 269 (1995) C1-C10
38. Garcia-Calvo M., Knaus H.-G., McManus O.B., Giangiacomo K.M., Kaczorowski G.J., and Garcia M.L. Purification and reconstitution of the high-conductance calcium-activated potassium channel from tracheal smooth muscle. J. Biol. Chem. 269 (1994) 676-682
39. 2+-activated channel from rabbit aorta: Modulation by cromakalim. Eur. J. Pharmacol. 167 (1989) 201-210
40. Giangiacomo K.M., Garcia M.L., and McManus O.B. Mechanism of iberiotoxin block of the large-conductance calcium-activated potassium channel from bovine aortic smooth muscle. Biochemistry 31 (1992) 6719-6727
41. Giangiacomo K.M., Garcia-Calvo M., Knaus H.-G., Mullmann T.J., Garcia M.L., and McManus O. Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle. Biochemistry 34 (1995) 15849-15862
42. Gribkoff V.K., Champigny G., Barbry P., Dworetzky S.I., Meanwell N.A., and Lazdunski M. The substituted benzimidazolone NS004 is an opener of the cystic fibrosis chloride channel. J. Biol. Chem. 269 (1994) 10983-10986
43. Gribkoff V.K., Boissard C.G., Lum-Ragan J.T., McKay M.C., Post-Munson D.J., Trojnacki J.T., and Dworetzky S.I. Transformation of hSlo BK (maxi-K) channel characteristics by co-expression of a human β-subunit. Biophys. J. 70 (1996) A193
44. +1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharacol. 45 (1994) 1227-1234
45. Hermann A., and Erxleben C. Charybdotoxin selectively blocks small Ca-activated K channels in Aplysia neurons. J. Gen. Physiol. 90 (1987) 27-47
46. Hermann A., and Gorman A. Effects of tetraethylammonium on potassium currents in a molluscan neuron. J. Gen. Physiol. 78 (1981) 87-110
47. Hiramatsu T., Kume H., Kotlikoff M.I., and Takagi K. Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscles by forskolin. Clin. Exp. Pharmacol. Physiol. 21 (1994) 367-375
48. Hudspeth A.J. How the ear's works work. Nature (Lond.) 341 (1989) 397-404
49. Hudspeth A.J., and Lewis R.S. Kinetic analysis of voltage- and ion-dependent conductances in saccular hair cells of the bull-frog, Rana catesbeiana. J. Physiol. (Lond.) 400 (1989) 237-274
50. Hudspeth A.J., and Lewis R.S. A model for electrical resonance and frequency tuning in saccular hair cells of the bull-frog, Rana catesbeiana. J. Physiol. (Lond.) 400 (1989) 275-297
51. Hughes M., Romey G., Duval D., Vincent J., and Lazdunski M. Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells. Voltage-clamp and biochemical characterization of the toxin receptor. Proc. Natl. Acad. Sci. USA 79 (1982) 1308-1312
52. + channels at fluorescently labeled presynaptic active zones of hair cells. Proc. Natl. Acad. Sci. USA 91 (1994) 7578-7582
53. Klockner U., and Isenberg G. The dihydropyridine niguldipine modulates calcium and potassium currents in vascular smooth muscle cells. Br. J. Pharmacol. 97 (1989) 957-967
54. Klockner U., Trieschmann U., and Isenberg G. Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells. Arzneimittelforsch. 39 (1989) 120-126
55. Knaus H.-G., Eberhart A., Glossmann H., Munujos P., Kaczorowski G.J., and Garcia M.L. Pharmacology and structure of high conductance calcium-activated potassium channels. Cell Signalling 6 (1994) 861-870
56. + channel from smooth muscle. J. Biol. Chem. 269 (1994) 17274-17278
57. Knaus H.-G., Garcia-Calvo M., Kaczorowski G.J., and Garcia M.L. Subunit composition of the high-conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J. Biol. Chem. 269 (1994) 3921-3924
58. Knaus H.-G., McManus O.B., Lee S.H., Schmalhofer W.A., Garcia-Calvo M., Helms L.M.H., Sanchez M., Giangiacomo K.M., Reuben J.P., Smith III A.B., Kaczorowski G.J., and Garcia M.L. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33 (1994) 5918-5928
59. + channels in rat brain: Targeting to axons and nerve terminals. J. Neurosci. 16 (1996) 955-963
60. + channels in myelinated nerve fibres of Xenopus laevis. Neurosci. Lett. 165 (1994) 167-170
61. Kume H., Mikawa K., Takagi K., and Kotlikoff M.I. Role of G proteins and Kc. channels in the muscarinic and P-adrenergic regulation of airway smooth muscle. Am. J. Physiol. 268 (1995) L221-L229
62. Lagrutta A., Shen K.-Z., North R.A., and Adelman J.P. Functional differences among alternatively spliced variants of Slowpoke, a Drosophila calcium-activated potassium channel. J. Biol. Chem. 269 (1994) 20347-20351
63. Lancaster B., and Adams P.R. Calcium-dependent current generating the afterhyper-polarization of hippocampal neurons. J. Neurophysiol. 55 (1986) 1268-1282
64. Lancaster B., and Nicoll R.A. Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J. Physiol. (Lond.) 389 (1987) 187-204
65. Lancaster B., Nicoll R.A., and Perkel D.J. Calcium activates two types of potassium channels in rat hippocampal neurons in culture. J. Neurosci. 11 (1991) 23-30
66. Latorre R., Oberhauser A., Labarca P., and Alvarez O. Varieties of calcium-activated potassium channels. Annu. Rev. Physiol. 51 (1989) 385-399
67. Laurent F., Michel A., Bonnet P.A., Chapat J.P., and Boucard M. Evaluation of the relaxant effects of SCA40, a novel charybdotoxin-sensitive potassium channel opener, in guinea-pig isolated trachealis. Br. J. Pharmacol. 108 (1993) 622-626
68. + currents in rabbit coronary myocytes. Am. J. Physiol. 266 (1994) C1523-C1537
69. Lee K., Rowe I.C.M., and Ashford M.L.J. NS 1619 activates BK(Ca) channel activity in rat cortical neurones. Eur. J. Pharmacol. 280 (1995) 215-219
70. Lindgren C.A., and Moore J.W. Identification of ionic currents at presynaptic nerve endings of the lizard. J. Physiol. (Lond.) 414 (1989) 201-222
71. + current in arterial smooth muscle cells from aldosterone-salt hypertensive rats. Am. J. Physiol. 269 (1995) H1246-H1257
72. + channel. J. Gen. Physiol. 91 (1988) 335-349
73. + channels in bovine tracheal smooth muscle cells in culture. Br. J. Pharmacol. 116 (1995) 1656-1660
74. Magleby K.L., and Pallotta B.S. Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle. J. Physiol. (Lond.) 344 (1983) 584-604
75. McCobb D.P., Fowler N.L., Featherstone T., Lingle C.L., Saito M., Krause J.E., and Salkoff L. A human calcium-activated potassium channel gene expressed in vascular smooth muscle. Am. J. Physiol. 269 (1995) H767-H777
76. McKay M.C., Dworetzky S.I., Meanwell N.A., Olesen S.-P., Reinhart P.H., Levitan I.B., Adelman J.P., and Gribkoff V.K. Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004. J. Neurophysiol. 71 (1994) 1873-1882
77. McManus O.B. Calcium-activated potassium channels: Regulation by calcium. J. Bioenerg. Biomembr. 23 (1991) 537-560
78. McManus O.B., Harris G.H., Giangiacomo K.M., Feigenbaum P., Reuben J.P., Addy M.E., Burka J.F., Kaczorowski G.J., and Garcia M.L. An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry 32 (1993) 6128-6133
79. McManus O.B., Helms L.M.H., Pallanck L., Ganetzky B., Swanson R., and Leonard R.J. Functional role of the fl subunit of high conductance calcium-activated potassium channels. Neuron 14 (1995) 645-650
80. + channel-blocking peptides. Neuron 15 (1995) 5-10
81. + channels from mammalian skeletal muscle. Nature (Lond.) 313 (1985) 316-318
82. + channel of vascular smooth muscle cells. Life Sci. 56 (1995) 291-298
83. 2+-activated Kt channels from rat muscle incorporated into planar lipid bilayers. J. Gen. Physiol. 82 (1983) 511-542
84. Morita K., and Barrett E.F. Evidence for two calcium-dependent potassium conductances in lizard motor nerve terminals. J. Neurosci. 10 (1990) 2614-2625
85. K+ channel from skeletal muscle. J. Gen. Physiol. 92 (1988) 67-86
86. K+ channels. Exp. Opin. Invest. Drugs 3 (1994) 1181-1188
87. Olesen, S.-P., Jensen, L. H., Moldt, P., and Thaning, M. (1992). Indole derivatives as potassium channel blockers. U.S. Patent 5, 158, 969.
88. + channels in aortic smooth muscle. Br. J. Pharmacol. 110 (1993) C25
89. + channels by novel benzimidazolone. Eur. J. Pharmacol. 251 (1994) 53-57
90. + channels in cerebellar granule cells. NeuroReport 5 (1994) 1001-1004
91. Ondeyka J.G., Ball R.G., Garcia M.L., Dombrowski A.W., Sabnis G., Kaczorowski G.J., Zinc D.L., Bills G.F., Goetz M.A., Schmalhofer W.A., and Singh S.B. A carotene sesquiterpene as a potent modulator of the maxi-K channel from Arthrinium phaesopermum. Bioorg. Med. Chem. Lett. 5 (1995) 733-734
92. Ottolia M., and Toro L. Potentiation of large conductance Kc. channels by niflumic, flufenamic and mefenamic acids. Biophys. J. 67 (1994) 2272-2279
93. Pancrazio J.J., Johnson P.A., and Lynch C. A major role for calcium-dependent potassium current in action potential repolarization in adrenal chromaffin cells. Brain Res. 668 (1994) 246-251
94. Perez G., and Toro L. Differential modulation of large-conductance Kca channels by PKA in pregnant and non-pregnant myometrium. Am. J. Physiol. 266 (1994) C1459-C1463
95. Petersen O.H., and Maruyama Y. Calcium-activated potassium channels and their role in secretion. Nature 307 (1984) 693-696
96. Reinhart P.H., Chung S., and Levitan I.B. A family of calcium-dependent potassium channels from rat brain. Neuron 2 (1989) 1031-1041
97. Reinhart P.H., Chung S., Martin B.L., Brautigan D.L., and Levitan I.B. Modulation of calcium-activated potassium channels from rat brain by protein kinase A and phospha- tase 2A. J. Neurosci. 11 (1991) 1627-1635
98. Rettig J., Heinemann S.H., Wunder F., Lorra C., Parcej D.N., Dolly J.O., and Pongs O. Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit. Nature 369 (1994) 289-294
99. Roberts W.M., Jacobs R.A., and Hudspeth A.J. Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells. J. Neurosci. 10 (1990) 3664-3684
100. Robitaille R., and Charlton M.P. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels. J. Neurosci. 21 (1992) 297-305
101. Robitaille R., Garcia M.L., Kaczorowski G.J., and Charlton M.P. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release. Neuron 11 (1993) 645-655
102. Rudy B. Diversity and ubiquity of K channels. Neuroscience 25 (1988) 729-749
103. + channels conserved in flies, mice and humans. Trends Neurosci. 15 (1992) 151-166
104. Sargent C.A., Grover G.J., Antonaccio M.J., and McCullough J.R. The cardiopro- tective, vasorelaxant and electrophysiological profile of the large-conductance calcium-activated potassium channel opener NS-004. J. Pharmacol. Exp. Ther. 266 (1993) 1422-1429
105. Sellers A.J., and Ashford M.L.J. Activation of BKc. channels in acutely dissociated neurones from the rat ventromedial hypothalamus by NS1619. Br. J. Pharmacol. 113 (1994) 659-661
106. Singh B.S., Goetz M.A., Zink D.L., Dombrowski A.W., Polishook J.D., Garcia M.L., Schmalhofer W., McManus O.B., and Kaczorowski G.J. Maxikdiol: A novel dihydroxyisoprimane as an agonist of maxi-K channels. J. Chem. Soc. Perkin Trans. 1 (1994) 3349-3352
107. Sivaramakrishnan S., Bittner G.D., and Brodwick M.S. Calcium-activated potassium conductance in presynaptic terminals at the crayfish neuromuscular junction. J. Gen. Physiol. 98 (1991) 1161-1179
108. Sokol P.L., Hu W., Yi L., Toral J., Chandra M., and Ziai M.R. Cloning of an apamin binding protein of vascular smooth muscle. J. Protein Chem. 13 (1994) 117-128
109. Solaro C.R., and Lingle C.J. Trypsin-sensitive, rapid inactivation of a calcium-activated potassium channel. Science (USA) 257 (1992) 1694-1698
110. + current in rat adrenal chromaffin cells. J. Neurosci. 15 (1995) 6110-6123
111. Storm J.F. Action potential repolarization and a fast afterhyperpolarization in rat hippocampal pyramidal cells. J. Physiol. (Lond.) 385 (1987) 733-759
112. Stretton D., Miura M., Belvisi M.G., and Barnes P.J. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. USA 89 (1992) 1325-1329
113. + channel. J. Biol. Chem. 265 (1990) 18745-18748
114. Toro L., Vaca L., and Stefani E. Calcium-activated potassium channels from coronary smooth muscle reconstituted in lipid bilayers. Am. J. Physiol. 260 (1991) H1779-H1789
115. + channel isoforms from human brain. Neuron 13 (1994) 1315-1330
116. + channel with quaternary ammonium ions. Pflugers Arch. 413 (1988) 118-126
117. 2+ current in isolated terminal of the rat neurohypophysis. Pfltrgers Arch. 421 (1992) 558-565
118. Wang G., Thorn P., and Lemos J.R. A novel large-conductance Caz+-activated potassium channel and current in nerve terminals of the rat neurohypophysis. J. Physiol. (Lond.) 457 (1992) 47-74
119. + channels participate in the regulation of pituitary prolactin secretion. Brain Res. 662 (1994) 83-87
120. + channels of high conductance in smooth muscle cells isolated from rat cerebral arteries. J. Physiol. (Lond.) 462 (1993) 529-545
121. Wann K.T., and Richards C.D. Properties of single calcium-activated potassium channels of large conductance in rat hippocampal neurons in culture. Eur. J. Neurosci. 6 (1994) 607-617
122. - channels in Xenopus oocytes. Moi. Pharmacol. 37 (1990) 720-724
123. Xu X., Tsai T.D., Wang J., Lee E.W., and Lee K.S. Modulation of three types of K+ currents in canine coronary artery smooth muscle cells by NS-004, or 1-(2'-hydroxy-5'-chlorophenyl)-S-trifluoromethyl-2(3H) benzimidazolone. J. Pharmacol. Exp. Ther. 271 (1994) 362-369
124. Zhang L., and McBain C.J. Voltage-gated potassium currents in stratum-oriens-alveus inhibitory neurones of the rat CA1 hippocampus. J. Physiol. (Lond.) 488 (1995) 647-660
125. Zhang L., and McBain C.J. Potassium conductances underlying repolarization and afterhyperpolarization in rat CA1 hippocampal interneurones. J. Fhysiol. (Lond.) 488 (1995) 661-672