Engineering antibodies for biosensor technologies

Advances in Applied Microbiology

Volumn 58, Issue , 2005, Pages 185-226

  Goodchild, Sarah ^a   Love, Tracey ^a   Hopkins, Neal ^a   Mayers, Carl ^a  

^a DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CHAPERONE; HYBRID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G; METALLOPROTEIN; MONOCLONAL ANTIBODY; PAPAIN; POLYCLONAL ANTIBODY; RECOMBINANT ANTIBODY; RECOMBINANT PROTEIN;

ANTIBODY COMBINING SITE; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; BACILLUS ANTHRACIS; BIOSENSOR; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMOBILIZATION; IN VITRO STUDY; MATURATION; NONHUMAN; PICHIA PASTORIS; PROTEIN TARGETING; REVIEW; TECHNIQUE; TECHNOLOGY;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; BIOSENSING TECHNIQUES; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULINS; MICE; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PICHIA PASTORIS;

EID: 33644919974     PISSN: 00652164     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2164(05)58006-7     Document Type: Review

References (206)

1. Ahluwalia A., Derossi D., Ristori C., Schirone A., and Serra G. A comparativestudy of protein immobilisation techniques for optical immunosensors Biosens. Bioelectron. 7 1992 207 214
2. Allard L., Cheynet V., Oriol L., Veron F., Merlier G., Scremin G., Mandrand B., Delair T., and Mallet F. Mechanisms leading to an orientated immobilization of recombinant proteins derived from the p24 capsid of HIV-1 onto copolymers Bioconjugate Chem. 12 2001 972 979
3. Allard L., Cheynet V., Oriol G., Mandrand B., Delair T., and Mallet F. Versatile method for production and controlled polymer-immobilisation of biologically active recombinant proteins Biotechnol. Bioeng. 80 2002 341 348
4. Amstutz P., Forrer P., Zahnd C., and Plückthun A. In vitro display technologies: Novel developments and applications Curr. Opin. Biotech. 12 2001 400 405
5. Andreotti P.E., Ludwig G.V., Peruski A.H., Tuite J.J., Morse S.S., and Peruski L.F. Immunoassay of infectious agents Biotechniques 35 2003 850 859
6. Arndt K., Pelletier J., Muller K., Alber T., Michnick S., and Pluckthun A. A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble J. Mol. Biol. 295 2000 627 639
7. Arndt K., Pelletier J., Muller K., Pluckthun A., and Alber T. Comparison of in vivo selection and rational design of heterodimeric coiled coils Structure 10 2002 1235 1248
8. Arnold S., Khoshsima M., Teraoka I., Holler S., and Vollmer F. Shift of whispering gallery modes in microspheres by protein adsorption Opt. Lett. 28 2003 272 274
9. Bach H., Mazor Y., Shaky S., Shoham-Lev A., Berdichevsky Y., Gutnick D.L., and Benhar I. Escherichia coli maltose-binding protein as a molecular chaperone for recombinant intracellular cytoplasmic single-chain antibodies J. Mol. Biol. 312 2001 79 93
10. Baeumner A.J., Pretz J., and Fang S. A universal nucleic acid sequence biosensor with nanomolar detection limits Anal. Chem. 76 2004 888 894
11. Barbas C.F., Bain J.D., Hoekstra D.M., and Lerner R.A. Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem Proc. Natl. Acad. Sci. USA 89 1992 4457 4461
12. Bessette P., Aslund F., Beckwith J., and Georgiou G. Efficient folding of proteins with multiple disulphide bonds in the Escherichia coli cytoplasm Proc. Natl. Acad. Sci. USA 96 1999 13703 13708
13. Blanke S., Milne J., Benson E., and Collier R. Fused polycationic peptide mediates delivery of diptheria toxin A chain to the cytosol in the presence of anthrax protective antigen Proc. Natl. Acad. Sci. USA 93 1996 8437 8442
14. Boder E.T., and Wittrup K.D. Yeast surface display for screening combinatorial polypeptide libraries Nat. Biotechnol. 15 1997 553 557
15. Boder E.T., Midelfort K.S., and Wittrup K.D. Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity Proc. Natl. Acad. Sci. USA 97 2000 10701 10705
16. Boozer C., Yu Q.M., Chen S.F., Lee C.Y., Homola J., Yee S.S., and Jiang S.Y. Surface functionalization for self-referencing surface plasmon resonance (SPR) biosensors by multi-step self-assembly Sensor. Actuat. B-Chem. 90 2003 22 30
17. Bothmann H., and Pluckthun A. Selection for a periplasmic factor improving phage display and functional periplasmic expression Nat. Biotechnol. 16 1998 376 380
18. Bradbury A.R.M., and Marks J.D. Antibodies from phage antibody libraries J. Immunol. Methods 290 2004 29 49
19. Bregegere F., Schwartz J., and Bedouelle H. Bifunctional hybrids between the variable domains of an immunoglobulin and the maltose binding protein of Escherichia coli: Production, purification and antigen binding Protein Eng. 7 1994 271 280
20. Brockmann E-C., Cooper M., Strömsten N., Vehniäinen M., and Saviranta P. Selecting for antibody scFv fragments with improved stability using phage display with denaturation under reducing conditions J. Immunol. Methods 296 2005 159 170
21. Brogan K.L., Wolfe K.N., Jones P.A., and Schoenfisch M.H. Direct oriented immobilization of F(ab') antibody fragments on gold Anal. Chim. Acta 496 2003 73 80
22. Brown S. Metal-recognition by repeating polypeptides Nat. Biotechnol. 15 1997 269 272
23. Brown W.C., and Campbell J.L. A new cloning vector and expression strategy for genes encoding proteins toxic to Escherichia coli Gene 127 1993 99 103
24. Byfield M.P., and Abuknesha R.A. Biochemical aspects of biosensors Biosens. Biolelectron. 9 1994 373 400
25. Cai X., and Garen A. Anti-melanoma antibodies from melanoma patients immunised with genetically autologous tumour cells: Selection of specific antibodies from single-chain Fv fusion phage libraries Proc. Natl. Acad. Sci. USA 92 1995 6537 6541
26. Casero E., Vazquez L., Martin-Benito J., Morcillo M., Lorenzo E., and Pariente F. Immobilization of metallothionein on gold/mica surfaces: Relationship between surface morphology and protein-substrate interaction Langmuir 18 2002 5909 5920
27. Catimel B., Nerrie M., Lee F.T., Scott A.M., Ritter G., Welt S., Old L.J., Burgess A.W., and Nice E.C. Kinetic analysis of the interaction between the monoclonal antibody A33 and its colonic epithelial antigen by the use of an optical biosensor - A comparison of immobilisation strategies J. Chromatogr. A 776 1997 15 30
28. Chao H., Bautista D., Litowski J., Irvin R., and Hodges R. Use of a heterodimeric coiled-coil system for biosensor application and affinity purification J. Chromatogr. B 715 1998 307 329
29. 2 fragments using Gradiflow technology Protein Expres. Purif. 32 2003 135 140
30. Clackson T., Hoogenboom H.R., Griffiths A.D., and Winter G. Making antibody fragments using phage display libraries Nature 352 1991 624 628
31. Cline J., and Hogrefe H.H. Randomizing gene sequences with new PCR mutagenesis kit Strategies 13 2000 157 161
32. Coia G., Ayres A., Lilley G.G., Hudson P.J., and Irving R.A. Use of mutator cells as a means for increasing production levels of a recombinant antibody directed against Hepatitis B Gene 201 1997 203 209
33. Culpit P., Whyte J., Porter A., Browne M., Hlomes S., Harris W., and Cunningham C. Cloning and characterization of single chain antibody fragments in Escherichia coli and Pichia pastoris Lett. Appl. Microbiol. 29 1999 273 277
34. Daugherty P.S., Chen G., Iverson B.L., and Georgiou G. Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies Proc. Natl. Acad. Sci. USA 97 2000 2029 2034
35. de Haard H.J., van Neer N., Reurs A., Hufton S.E., Roovers R.C., Henderikx P., de Bruine A.P., Arends J.W., and Hoogenboom H.R. A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies J. Biol. Chem. 274 1999 18218 18230
36. De Silva A.P., Gunaratne H.Q.N., Gunnlaugsson T., Huxley A.J.M., McCoy C.P., Rademacher J.T., and Rice T.E. Signalling recognition events with fluorescent sensors and switches Chem. Rev. 97 1997 1515 1566
37. Dillon P.P., Daly S.J., Killard A.J., and O'Kennedy R. Development and use of antibodies in surface plasmon resonance-based immunosensors for environmental monitoring Intern. J. Environ. Anal. Chem. 83 2003 525 543
38. Dooley H., Flajnik M.F., and Porter A.J. Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display Mol. Immunol. 40 2003 25 33
39. Dooley H., Grant S.D., Harris W.J., and Porter A.J. Stabilization of antibody fragments in adverse environments Biotechnol. Appl. Biochem. 28 1998 77 83
40. Dong L., Chen S., Bartsch U., and Schachner M. Generation of affinity matured scFv antibodies against mouse neural cell adhesion molecule L1 by phage display Bio. Biophys. Res. Comm. 301 2003 60 70
41. Duan L.X., and Pomerantz R.J. Elimination of endogenous aberrant kappa-chain transcripts from Sp2/0-derived hybridoma cells by specific ribozyme cleavage - utility in genetic therapy of Hiv-1 infections Nucleic Acids Res. 22 1994 5433 5438
42. Egodage K.L., and Wilson G.S. Antibodies as immobilization reagents T. Cass F.S. Ligler "Immobilized Biomolecules in Analysis: A Practical Approach" 1998 Oxford University Press New York 35 53
43. Eldin P., Pauze M., Heida Y., Lin G., Murtaugh M., Pental P., and Pennell C. High-level secretion of two antibody single chain Fv fragments by Pichia pastoris J. Immunol. Methods 201 1997 67 75
44. Emanuel P.A., Dang J., Gebhardt J.S., Aldrich J., Garber E.A.E., Kulaga H., Stopa P., Valdes J.J., and Dion-Scultz Recombinant antibodies: A new reagent for biological detection Biosens. Bioelectron. 14 2000 751 759
45. Ewert S., Cambillau C., Conrath K., and Pluckthun A. Biophysical properties of camelid VHH domains compared to those of human VH3 domains Biochemistry 41 2002 3628 3636
46. Ewert S., Honegger A., and Plückthun A. Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering Methods 34 2004 184 199
47. Fägerstam L.G., Frostellkarlsson A., Karlsson R., Persson B., and Ronnberg I. Biospecific interaction analysis using surface-plasmon resonance detection applied to kinetic, binding-site and concentration analysis J. Chromatogr. 597 1992 397 410
48. Ferapontova E., Grigorenko V., and Egorov A. P-chip and P-chip bienzyme electrodes based on recombinant forms of horseradish peroxidase immobilized on gold electrodes Biochemistry (Moscow) 66 2001 832 839
49. Fermer C., Andersson I., Nilsson K., and Nilsson O. Specificity rescue and affinity maturation of a low-affinity IgM antibody against pro-gastrin-releasing peptide using phage display and DNA shuffling Tumor Biol. 25 2004 7 13
50. Fernandez L., and de Lorenzo V. Formation of disulphide bonds during secretion of proteins through the periplasmic-independent type-1 pathway Mol. Microbiol. 40 2001 332 346
51. Fernandez L. Prokaryotic expression of antibodies and affibodies Curr. opin. Biotech. 15 2004 364 373
52. Fratamico P.M., Strobaugh T.M., Medina M.B., and Gehring A.G. Detection of Escherichia Coli O157:H7 using a surface plasmon resonance biosensor Biotechnol. Tech. 12 1998 571 576
53. Georgiou G., and Valax P. Expression of correctly folded proteins in Escherichia coli Curr. Opin. Biotech. 7 1996 190 197
54. Gershon P., and Khilko S. Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BIAcore surface plasmon resonance detector J. Immunol. Methods 183 1995 65 76
55. Ghahroudi M.A., Desmyter A., Wyns L., Hamers R., and Muyldermans S. Selection and identification of single domain antibody fragments from camel heavy-chain antibodies FEBS Lett. 414 1997 521 526
56. Glaser S.M., Yelton D.E., and Huse W.D. Antibody engineering by codon-based mutagenesis in a filamentous phage vector system J. Immunol. 15 1992 3903 3913
57. Glockshuber R., Malia M., Pfitzinger I., and Pluckthun A. A comparison of strategies to stabilize immunoglobulin Fv-fragments Biochemistry 29 1990 1362 1367
58. Glockshuber R., Schmidt T., and Pluckthun A. The disulphide bonds in antibody variable domains: Effects on stability, folding in vitro and functional expression in Escherichia coli Biochemistry 31 1992 1270 1279
59. Goldbaum F.A., Velikovsky C.A., Dall'acqua W., Fossati C.A., Fields B.A., Braden B.C., Poljak R.J., and Mariuzza R.A. Characterization of [anti?]-anti-idiotypic antibodies that bind antigen and an anti-idiotype Proc. Natl. Acad. Sci. USA 94 1997 8697 8701
60. Goto Y., and Hamaguchi K. The role of the intrachain disulphide bond in the conformation and stability of the constant fragment of the immunoglobulin light chain J. Biochem. 86 1979 1433 1441
61. Graff C.P., Chester K., Begent R., and Wittrup K.D. Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37°C Protein Engineering Design and Selection 17 2004 293 304
62. Green N. Avidin Adv. Protein Chem. 29 1975 85 133
63. Greenberg A.S., Avila D., Hughes M., Hughes A., Churchill McKinney E., and Flajnik M.F. A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks Nature 374 1995 168 173
64. Griffiths A.D., Malmqvist M., Marks J.D., Bye J.M., Embleton M.J., McCafferty J., Baier M., Holliger K.P., Gorick B.D., Hughesjones N.C., Hoogenboom H.R., and Winter G. Human anti-self antibodies with high specificity from phage display libraries EMBO J. 12 1993 725 734
65. Griffiths A.D., Williams S.C., Hartley O., Tomlinson I.M., Waterhouse P., Crosby W.L., Kontermann R.E., Jones P.T., Low N.M., Allison J.T., Hoogenboom H.R., Nissim A., Cox J.P.L., Harrison J.L., Zaccolo M., Gherardi E., and Winter G. Isolation of high affinity human antibodies directly from large synthetic repertoires EMBO J. 13 1994 3245 3260
66. Hamers-Casterman C., Atarhouch T., Muyldermans S., Robinson G., Hamers C., Bajyana Songa E., Bendahman N., and Hamers R. Naturally occurring antibodies devoid of light chains Nature 363 1993 446 448
67. Hanes J., Jermutus L., Weber-Bornhauser S., Bosshard H.R., and Pluckthun A. Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries Proc. Natl. Acad. Sci. USA 95 1998 14130 14135
68. Hanes J., and Plückthun A. In vitro selection and evolution of functional proteins by using ribosome display Proc. Natl. Acad. Sci. USA 94 1997 4937 4942
69. Hanes J., Schaffitzel C., Knappik A., and Plückthun A. Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display Nature Biotechnol. 18 2000 1287 1292
70. Hawkins R.E., Russell S.J., and Winter G. Selection of phage antibodies by binding affinity mimicking affinity maturation J. Mol. Biol. 226 1992 889 896
71. Hayhurst A., and Harris W. Escherichia coli Skp chaperone coexpression improves solubility and phage display of single-chain antibody fragments Protein Expres. Purif. 15 1999 336 343
72. Hayhurst A. Improved expression characteristics of single-chain Fv fragments when fused downstream of the Escherichia coli maltose-binding protein or upstream of a single immunoglobulin-constant domain Protein Expres. Purif. 18 2000 1 10
73. Hayhurst A., Happe S., Mabry R., Koch Z., Iverson B., and Georgiou G. Isolation and expression of recombinant antibody fragments to the biological warfare pathogen Brucella melitensis J. Immunol. Methods 276 2003 185 196
74. He M., and Taussig M.J. Ribosome display: Cell free protein display technology Brief. Funct. Genomic. Proteomic. 1 2002 204 212
75. Hearn M., and Acosta D. Applications of novel affinity cassette methods; use of peptide fusion handles for the purification of recombinant proteins J. Mol. Recognit. 14 2001 323 369
76. Hellinga H.W., and Marvin J.S. Protein engineering and the development of generic biosensors Trends Biotechnol. 16 1998 183 189
77. Hock B., Seifert M., and Kramer K. Engineering receptors and antibodies for biosensors Biosens. Bioelectron. 17 2002 239 249
78. Hodneland C., Lee Y., Min D., and Mrksich M. Selective immobilization of proteins to self-[assembelled?] monolayers presenting active site-directed capture ligands Proc. Natl. Acad. Sci. USA 99 2002 5048 5052
79. Hombach A., Pohl C., Heuser C., Sircar R., Diehl V., and Abken H. Isolation of single chain antibody fragments with specificity for cell surface antigens by phage display utilising internal image anti-idiotypic antibodies J. Immunol. Methods 218 1998 53 61
80. Hone D.C., Haines A.H., and Russell D.A. Rapid, Quantitative colorimetric detection of a lectin using mannose-stabilized gold nanoparticles Langmuir 19 2003 7141 7144
81. Hoogenboom H.R., de Bruïne A.P., Hufton S.E., Hoet R.M., Arends J-W., and Roovers R.C. Antibody phage display technology and its applications Immunotechnology 4 1998 1 20
82. Hoogenboom H.R., Griffiths A.D., Johnson K.S., Chiswell D.J., Hudson P., and Winter G. Multisubunit proteins on the surface of filamentous phage - methodologies for displaying antibody (Fab) heavy and light-chains Nucleic Acids Res. 19 1991 4133 4137
83. H gene segments rearranged in vitro J. Mol. Biol. 227 1992 381 388
84. Howell S., Kenmore M., Kirkland M., and Badley R.A. High-density immobilisation of an antibody fragment to a carboxymethylated dextran-linked biosensor surface J. Mol. Recognit. 11 1998 200 203
85. Hu W., Thompson H., Alvi A., Nagata L., Suresh M., and Fulton R. Development of immunofiltration assay by light addressable potentiometric sensor with genetically biotinylated recombinant antibody for rapid identification of Venezuelan equine encephalitis virus J. Immunol. Methods 289 2004 27 35
86. Hust M., and Dübel S. Mating antibody phage display with proteomics Trends Biotechnol. 22 2004 8 14
87. Ideno A., Furutani M., Iwabuchi T., Iida T., Iba Y., Kurosawa Y., Sakuraba H., Ohshima T., Kawarabayashi Y., and Maruyama T. Expression of foreign proteins in Escherichia coli by fusing with an archaeal FK506 binding protein Appl. Microbiol. Biot. 64 2004 99 105
88. Ilic B., Yang Y., and Craighead H.G. Virus detection using nanoelectromechanical devices App. Phys. Lett. 85 2004 2604 2606
89. Iqbal S.S., Mayo W.W., Bruno J.G., Bronk B.V., Batt C.A., and Chambers J.P. A review of molecular recognition technologies for detection of biological threat agents Biosens. Bioelectron. 15 2000 549 578
90. Irving R.A., Kortt A.A., and Hudson P.J. Affinity maturation of recombinant antibodies using E. coli mutator cells Immunotechnology 2 1996 127 143
91. Itoh K., Suzuki K., Ishiwata S., Tezuke T., Mizugaki M., and Suzuki T. Application of recombinant Fab fragment from a phage display library for sensitive detection of target antigen by an inhibitory ELISA system J. Immunol. Methods 203 1999 107 114
92. Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., and Kyrpides N. Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis Nature 423 2003 87 91
93. Ivnitski D., Abdel-Hamid I., Atanasov P., and Wilkins E. Biosensors for the detection of pathogenic bacteria Biosens. Bioelectron. 14 1999 599 624
94. Jermutus L., Honegger A., Schwesinger F., Hanes J., and Plückthun A. Tailoring in vitro evolution for protein affinity or stability Proc. Natl. Acad. Sci. USA 98 2001 75 80
95. Jespers L., Bonnert T.P., and Winter G. Selection of optical biosensors from chemisynthetic antibody libraries Protein Eng. Des. Sel. 17 2004 709 713
96. Jhaveri S.D., Kirby R., Conrad R., Maglott E.J., Bowser M., Kennedy R.T., Glick G., and Ellington A.D. Designed signalling aptamers that transduce molecular recognition to changes in fluorescence intensity J. Am. Chem. Soc. 122 2000 2469 2473
97. Jones R.G.A., and Landon J. A protocol for "enhanced pepsin digestion": A step by step method for obtaining pure antibody fragments in high yield from serum J. Immunol. Methods 275 2003 239 250
98. Ju H., and Leech D. Electrochemical study of a metallothionein modified gold disk electrode and its action on Hg2+ cations J. Electroanal. chem. 484 2000 150 156
99. Jung S., and Pluckthun A. Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting Protein Eng. 10 1997 959 966
100. Jurado P., Ritz D., Beckwith J., de Lorenzo V., and Fernandez L. Production of functional single-chain Fv antibodies in the cytoplasm of Escherichia coli J. Mol. Biol. 320 2002 1 10
101. Karlsson B., Pascher T., Nordling M., Arvidsson R., and Lundberg L. Expression of the blue copper protein azurin from Pseudomonas aeruginosa in Escherichia coli FEBS Lett. 246 1989 211 217
102. Kiefel M.J., and Itzstein M. Recent Advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes Chem. Rev. 102 2002 471 490
103. Kiefhaber T., Rudolf R., Kohler H., and Buchner J. Protein aggregation in vitro and in vivo: A quantitative model of the kinetic competition between folding and aggregation Biotechnology 9 1991 825 829
104. Kipriyanov S.M., Dubel S., Beitling F., Kontermann R., and Little M. Recombinant single-chain Fv fragments carrying C-terminal cysteine residues: Production of bivalent and biotinylated antibodies Mol. Immunol. 31 1994 1047 1058
105. Kipriyanov S., and Le Gall F. Generation and production of engineered antibodies Mol. Biotechnol. 26 2004 39 60
106. Kirby R., Cho E.J., Gehrke B., Bayer T., Park Y.S., Neikirk D.P., McDevitt J.T., and Ellington A.D. Aptamer-based sensor arrays for the detection and quantitation of proteins Anal. Chem. 76 2004 4066 4075
107. Kirkham P.M., Neri D., and Winter G. Towards the design of an antibody that recognizes a given protein epitope J. Mol. Biol. 285 1999 909 915
108. Knappik A., Liming G., Honegger A., Pack P., Fischer M., Wellnhofer G., Hoess A., Wölle J., Plückthun A., and Virnekä B. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides J. Mol. Biol. 296 2000 57 86
109. Knappik A., and Plückthun A. Engineered turns of a recombinant antibody improve its in vivo folding Protein Eng. 8 1995 81 89
110. Kodadek T., Reddy M.M., Olivos H.J., Bachhawat-Sikder K., and Alluri P.G. Synthetic molecules as antibody replacements Acc. Chem. Res. 37 2004 711 718
111. Kortt A.A., Oddie G.W., Iliades P., Gruen L.C., and Hudson P.J. Nonspecific amine immobilization of ligand can be a potential source of error in BIAcore binding experiments and may reduce binding affinities Anal. Biochem. 253 1997 103 111
112. Kranz D.M., Herron J.N., and Voss E.W. Mechanisms of ligand-binding by monoclonal anti-fluorescyl antibodies J. Biol. Chem. 257 1982 6987 6995
113. Krebber A., Bornhauser S., Burmester J., Honegger A., Willuda J., Bosshard H.R., and Plückthun A. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system J. Immunol. Methods 201 1997 35 55
114. Kuang Y., Biran I., and Watt D.R. Living bacterial cell array for genotoxin monitoring Anal. Chem. 76 2004 2902-2809.
115. Kurtzman A.L., Govindarajan S., Vahle K., Jones J.T., Heinrichs V., and Patten P.A. Advances in directed protein evolution by recursive genetic recombination: Applications to therapeutic proteins Curr. Opin. Biotech. 12 2001 361 370
116. Kwon Y., Han Z., Karatan E., Mrksich M., and Kay B.K. Antibody arrays prepared by cutinase-mediated immobilization on self-assembly monolayers Anal. Chem. 76 2004 5713 5720
117. Leung D.W., Chen E., and Goeddel D.V. A method for random mutagenesis of a defined DNA segment using a modified polymerase chain reaction J. Meth. Cell Mol. Biol. 1 1989 11 15
118. Levy R., Weiss R., Chen G., Iverson B., and Georgiou G. Production of correctly folded Fab antibody fragment in the cytoplasm of Escherichia coli trxB gor mutants via the coexpression of molecular chaperones Protein Expres. Purif. 23 2001 338 347
119. Lipovsek D., and Pluckthun A. In vitro protein evolution by ribosome display and mRNA display J. Immunol. Methods 290 2004 51 67
120. Lisdat F., and Karube I. Copper proteins immobilized on gold electrodes for (bio)analytical studies Biosens. Bioelectron. 17 2002 1051 1057
121. Liss M., Peterson B., and Prohaska E. An aptamer-based quartz crystal protein biosensor Anal. Chem. 74 2002 4488 4495
122. Low N.M., Holliger P., and Winter Mimicking somatic hypermutation: Affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain J. Mol. Biol. 260 1996 359 368
123. Lowe C.R. Chemoselective biosensors Curr. Opin. Chem. Biol. 3 1999 106 111
124. Luo D., Mah N., Wishart D., Zhang Y., Jacobs F., and Martin L. Construction and expression of bi-functional proteins of single-chain Fv with effector domains J. Biochem. 120 1996 229 232
125. Luo D., Geng M., Schultes B., Ma J., Xu D., Hazma N., Qi W., Noujaim A., and Madiyalakan R. Expression of a fusion protein of scFv-biotin mimetic peptide for immunoassay J. Biotechnol. 65 1998 225 228
126. Luppa P.B., Sokoll L.J., and Chan D.W. Immunosensors - principles and applications to clinical chemistry (Review) Clin. Chim. Acta 314 2001 1 26
127. Maly J., Illiano E., Sabato M., De Francesco M., Pinto V., Masci A., Masci D., Masojidek J., Sugiura M., Franconi R., and Pilloton R. Immobilization of engineered molecules on electrodes and optical surfaces Mater. Sci. Eng. C. 22 2002 257 261
128. Marose S., Lindemann C., Ulber R., and Scheper T. Optical sensor systems for bioprocess monitoring Trends Biotechnol. 17 1999 30 34
129. Marvin J.S., Corcoran E.E., Hattangadi N.A., Zhang J.V., Gere S.A., and Hellinga H.W. The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors Proc. Natl. Acad. Sci. USA 94 1997 4366 4371
130. Marvin J.S., and Hellinga H.W. Engineering biosensors by introducing fluorescent allosteric signal transducers: Construction of a novel glucose sensor J. Am. Chem. Soc. 120 1998 7 11
131. McCafferty J., Griffiths A.D., Winter G., and Chiswell D.J. Phage display antibodies: Filamentous phage displaying antibody variable domains Nature 348 1990 552 554
132. McCarthy B.J., and Hill A.S. Altering the fine specificity of an anti-Legionella single chain antibody by a single amino acid insertion J. Immunol. Methods 251 2001 137 147
133. Medintz I.L., Goldman E.R., Lassman M.E., Hayhurst A., Kusterbeck A.W., and Deschamps J.R. Self-assembled TNT biosensor based on modular multifunctional surface-tethered components Anal. Chem. 77 2005 365 372
134. Midelfort K.S., Hernandez H.H., Lippow S.M., Tidor B., Drennan C.L., and Wittrup K.D. Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody J. Mol. Biol. 343 2004 685 701
135. Miller J.H. Mutators in E. coli Mutat. Res. 409 1998 99 106
136. Miyazaki C., Iba Y., Yamada Y., Takahashi H., Sawada J., and Kurosawa Y. Changes in the specificity of antibodies by site-specific mutagenesis followed by random mutagenesis Protein Eng. 12 1999 407 415
137. Moghaddam A., Borgen T., Stacy J., Kausmally L., Simonsen B., Marvik O.L., Brekke O.L., and Braunagel M. Identification of scFv antibody fragments that specifically recognise the heroin metabolite 6-monoacetylmorphine but not morphine J. Immunol. Methods 280 2003 139 155
138. Moore G.L., and Maranas C.D. Computational challenges in combinatorial library design for protein engineering Am. Inst. Chem. Eng. 50 2004 262 272
139. Naik R., Brott L., Clarson S., and Stone M. Silica-precipitating peptides isolated from a combinatorial phage display peptide library J. Nanosci. Nanotechnol. 2 2002 95 100
140. Nenortas E., and Beckett D. Purification and characterization of intact and truncated forms of the Escherichia coli biotin carboxyl carrier subunit of acetyl-CoA carboxylase J. Biochem. 271 1996 7559 7567
141. Nieba L., Honegger A., Krebber C., and Pluckthun A. Disrupting the hydrophobic patches at the antibody variable/constant domain interface: Improved in vivo folding and physical characterization of an engineered scFv fragment Protein Eng. 10 1997 435 444
142. Nieba L., Nieba-Axmann S., Persson A., Hamalainen M., Edebratt F., Hansson A., Lidholm J., Magnusson K., Frostell Karlson A., and Plückthun A. BIACORE analysis of Histidine-tagged proteins using a chelating NTS sensor chip Anal. Biochem. 252 1997 217 228
143. Nisnevitch M., and Firer M.A. The solid phase in affinity chromatography: Strategies for antibody attachment J. Biochem. Bioph. Meth. 49 2001 467 480
144. Nissim A., Hoogenboom H.R., Tomlinson I.M., Flynn G., Midgley C., Lane D., and Winter G. Antibody fragments from a "single pot" phage display library as immunochemical reagents EMBO J. 13 1994 692 698
145. North J.R. Immunosensors - antibody-based biosensors Trends Biotechnol. 3 1985 180 186
146. Nyquist R.M., Eberhardt A.S., Silks L.A., Li Z., Yang X., and Swanson B.I. Characterization of self-assembled monolayers for biosensor applications Langmuir 16 2000 1793 1800
147. Ostermeier C., and Michel H. Improved cloning of antibody variable regions from hybridomas by an antisense-directed RNase H digestion of the P3-X63-Ag8.653 derived pseudogene mRNA Nucleic Acids Res. 24 1996 1979 1980
148. Pelletier J., Arndt K., Pluckthun A., and Michnick S. An in vivo library-versus-library selection of optimized protein-protein interactions Nature Biotechnol. 17 1999 683 690
149. Peluso P., Wilson D.S., Do D., Tran H., Venkatasubbaiah M., Quincy D., Heidecker B., Poindexter K., Tolani N., Phelan M., Witte L., Jung L.S., Wagner P., and Nock S. Optimizing antibody immobilization strategies for the construction of protein microarrays Anal. Biochem. 312 2003 113 124
150. Perkins E.A., and Squirrel D.J. Development of instrumentation to allow the detection of microorganisms using light scattering in combination with surface plasmon resonance Biosens. Bioelectron. 14 2000 853 859
151. Petrenko V.A., and Vodyanoy V.J. Phage display for detection of biological threat agents J. Microbiol. Meth. 53 2003 253 262
152. Piervincenzi R.T., Reichart W.M., and Hellinga H.W. Genetic engineering of single-chain antibody fragment for surface immobilization in an optical biosensor Biosens. Bioelectron. 13 1998 305 312
153. Porath J., Carlsson J., Olsson I., and Belfrage G. Metal chelate affinity chomatography, a new approach to protein fractionation Nature 258 1975 598 599
154. Proba K., Worn A., Honegger A., and Plückthun A. Antibody scFv fragments without disulfide bonds made by molecular evolution J. Mol. Biol. 275 1998 245 253
155. Read T.D., Peterson S.N., Tournasse N., Baillie L.W., Paulsen I.T., Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R., Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M., Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M., De Boy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C., Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y., Jiang L.X., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M., Watkins K.L., Nierman W.C., Hazen A., Cline R., Redmond C., Thwaite J.E., White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M., Hanna P.C., Kolsto A.B., and Fraser C.M. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria Nature 423 2003 81 86
156. Redmond C., Baillie L.W.J., Hibbs S., Moir A.J.G., and Moir A. Identification of proteins in the exosporium of Bacillus anthracis. Microbiology 150 2004 355 363
157. Reiersen H., Lobersli I., Loset G.A., Hvattum E., Simonsen B., Stacey J.E., McGregor D., FitzGerald K., Welschof M., Brekke O.H., and Marvik O.J. Covalent antibody display - an in vitro antibody-DNA library selection system Nucleic Acid Res. 33 2005 1 9
158. Renard M., Belkadi L., Hugo N., England P., Altschuh D., and Bedouelle H. Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies J. Mol. Biol. 318 2002 429 442
159. Renard M., Belkadi L., and Bedouelle H. Deriving topological constraints from functional data for the design of reagentless fluorescent immunosensors J. Mol. Biol. 326 2003 167 175
160. Rich R., and Myska D. Advances in surface plasmon resonance biosensor analysis Curr. Opin. Biotech. 11 2000 54 61
161. Rich R.L., and Myszka D.G. Survey of the year 2003 commercial optical biosensor literature J. Mol. Recognit. 18 2005 1 39
162. Rider H., Petrovick M.S., Nargi F.E., Harper J.D., Schwoebel E.D., Mathews R.H., Blanchard D.J., Bortolin L.T., Young A.M., Chen J., and Hollis M.A. A B-cell based biosensor for rapid identification of pathogens Science 301 2003 213 215
163. Rinaldi R., and Cingolani R. Electronic nanodevices based on self-assembled metalloproteins Physica. E 21 2004 45 60
164. Roberts R.W., and Szostak J.W. RNA-peptide fusion for the in vitro selection of peptides and proteins Proc. Natl. Acad. Sci. USA 94 1997 12297 12302
165. Rojas G., Talavera A., Munoz Y., Rengifo E., Krengel U., Angstrom J., Gavilondo J., and Moreno E. Light-chain shuffling results in successful phage display selection of functional prokaryotic - expressed antibody fragments to N-glycolyl GM3 ganglioside J. Immunol. Methods 293 2004 71 83
166. Roux K.H., Greenberg A.S., Greene L., Strelets L., Avila D., Churchill Mikinney E., and Flajnik M.F. Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins Proc. Natl. Acad. Sci. USA 95 1998 11804 11809
167. Russell S.J., Hawkins R.E., and Winter G. Retroviral vectors displaying functional antibody fragments Nucleic Acids Res. 21 1993 1081 1085
168. Santala V., and Lamminmaki U. Production of a biotinylated single-chain antibody fragment in the cytoplasm of Escherichia coli J. Immunol. Methods 284 2004 165 175
169. Schatz P. Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: A 13-residue consensus peptide specifies biotinylation in Escherichia coli Biotechnology 11 1993 1138 1143
170. Schlieker C., Bukau B., and Mogk A. Prevention and reversion of protein aggregation by molecular chaperones in the E. coli cytosol: Implications for
171. Schmiedl A., Breitling F., Winter C., Queitsch I., and Dubel S. Effects of unpaired cysteines on yield, solubility and activity of different recombinant antibody constructs expressed in E. coli J. Immunol. Methods 242 2000 101 114
172. Schone C., Wilton-Smith P., Appleton N., Hambleton P., Modi N., Gatley S., and Melling J. Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bio-assay Appl. Environ. Microb. 50 1985 63 67
173. Schriver-Lake L.C. Silane-modified surfaces for biomaterial immobilization T. Cass F.S. Ligler "Immobilized Biomolecules in Analysis: A Practical Approach" 1998 Oxford Univeristy Press New York 1 14
174. Schultz J., Lin Y., Sanderson J., Zuo Y., Stone D., Mallett R., Wilbert S., and Axworthy D. A tetravalent single-chain antibody-streptavidin fusion protein for pretargeted lymphoma therapy Cancer res. 60 2000 6663 6669
175. Selvin P.R. The renaissance of fluorescence resonance energy transfer Nature Struct. Biol. 7 2000 730 734
176. Shen Z., Stryker G., Mernaugh R., Yu L., Yan H., and Zeng X. Single-chain fragment antibody piezoimmunosensors Anal. Chem. 77 2005 797 805
177. Skerra A. Engineered protein scaffolds for molecular recognition J. Mol. Recognit. 13 2000 167 187
178. Skerra A., and Pluckthun A. Assembly of a functional immunoglobulin-Fv fragment in Escherichia coli Science 240 1988 1038 1041
179. Smith G.P. Filamentous fusion phage - novel expression vectors that display cloned antigens on the virion surface Science 228 1985 1315 1317
180. Soh N., Tokuda T., Watanabe T., Mishima K., Imato T., Masadome T., Asano Y., Okutani S., Niwa O., and Brown S. A surface plasmon resonance immunosensor for detecting a dioxin precursor using a gold binding peptide Talanta 60 2003 733 745
181. Stemmer W.P.C. DNA shuffling by random fragmentation and reassembly in vitro recombination for molecular evolution Proc. Natl. Acad. Sci. USA 91 1994 10747 10751
182. Studentsov Y.Y., Schiffmann M., Strickler H.D., Ho G.Y.F., Pang Y.S., Schiler J., Herrero R., and Burk R.D. Enhanced enzyme-linked Immunosorbent assay for detection of antibodies to virus like particles of uman papillomavirus J. Clin. Microbiol. 40 2002 1755 1760
183. Subramanian A., and Velander A. Effect of antibody orientation on immunosorbent performance J. Mol. Recognit. 9 1996 528 535
184. Sugamata Y., and Shiba T. Improved secretory production of recombinant proteins by random mutagenesis of hlyB, an alpha-hemolysin transporter from Escherichia coli Appl. Environ. Microb. 71 2005 656 662
185. Thomas R., Patenaude S.I., MacKenzie C.R., To R., Hirama T., Young N.M., and Evans S.V. Structure of an anti-blood group A Fv and improvement of its binding affinity without loss of specificity J. Biol. Chem. 277 2002 2059 2064
186. Todd S.J., Moir A.J., Johnson M.J., and Moir A. Genes of Bacillus cereus and Bacillus anthracis encoding proteins of the exosporium J. Bacteriol. 185 2003 3373 3378
187. Tsao K., DeBarbieri B., Michel H., and Waugh D. A versatile plasmid expression vector for the production of biotinylated proteins by site-specific, enzymatic modification in Escherichia coli Gene 169 1996 59 64
188. Uithoven K.A., Schmidt J.C., and Ballman M.E. Rapid identification of biological warfare agents using an instrument employing a light addressable potentimetric sensor and a flow-through immunofiltration-enzyme assay system Biosens. Bioelectron. 14 2000 761 770
189. Ullrich H.D., Patten P.A., Yang P.L., Romesberg F.E., and Schultz P.G. Expression studies of catalytic antibodies Proc. Natl. Acad. Sci. USA 92 1995 11907 11911
190. van den Beucken T., Pieters H., Steukers M., van der Vaart M., Ladner R.C., Hoogenboom H.R., and Hufton S.E. Affinity maturation of Fab antibody fragment by fluorescent-activated cell sorting of yeast-displayed libraries. FEBS Lett. 546 2003 288 294
191. Vijayendran R.A., and Leckband D.E. A quantitative assessment of heterogeneity for surface-immobilized proteins Anal. Chem. 73 2001 471 480
192. Wang J., Rivas G., Parrado C., Xiaohua C., and Flair M. Electrochemical biosensor for detection DNA sequences from the pathogenic protozoan Cryptosporidium parvum Talanta 44 1997 2003 2010
193. Ward E.S., Gussow D., Griffiths A.D., Jones P.T., and Winter G. Binding activities of a repertoire of single immunoglobulin variable domains secreted from E. coli Nature 341 1989 544 546
194. Whaley S., English D., Hu E., Barbara P., and Belcher A. Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly Nature 405 2000 665 668
195. Williams D.D., Benedek O., and Turnbough C.L. Species-specific peptide ligands for the detection of Bacillus anthracis spores Appl. Environ. Microb. 69 2003 6288-6239.
196. Winter G. Synthetic human antibodies and a strategy for protein engineering FEBS Lett. 430 1998 92 94
197. Winter G., Griffiths A.D., Hawkins R.E., and Hoogenboom H.R. Making antibodies by phage display technology Ann. Rev. Immunol. 12 1994 433 455
198. Woodbury R., Wendin C., Clendenning J., Melendez J., Elkind J., Bartholemew D., Brown S., and Furlong C. Construction of biosensors using a gold-binding polypeptide and a minature integrated surface plasmon resonance sensor Biosens. Bioelectron. 13 1998 1117 1126
199. Wörn A., and Pluckthün A. An intrinsically stable antibody scFv fragment can tolerate the loss of both disulphide bonds and fold correctly FEBS Lett. 427 1998 357 361
200. Wu T.Z., Wang H., and Au L.C. Gene probe coated piezoelectric biosensors for biochemical analysis Clin. J. Microbiol. Immunol. 23 1990 147 154
201. Wulfing C., and Pluckthun A. Protein folding in the periplasm of Escherichia coli Mol. Microbiol. 12 1994 685 692
202. Zaccolo M., Williams D.M., Brown D.M., and Gherardi E. An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues J. Mol. Biol. 255 1996 589 603
203. Zhang Z., Li Z., Wang F., Fang M., Yin C., Zhou Z., Lin Q., and Huang H. Overexpression of DsbC and DsbG markedly improves soluble and functional expression of single-chain Fv antibodies in Escherichia coli Protein Expres. Purif. 26 2002 218 228
204. Zhang Z., Song L.P., Fang M., Wang F., He D., Zhao R., Liu J., Zhou Z.Y., Yin C.C., Lin Q., and Huang H.L. Production of soluble and functional engineered antibodies in Escherichia coli improved by FkpA Biotechniques 35 2003 1032 1038
205. Zheng L., Baumann U., and Reymond J.L. Production of a functional catalytic antibody ScFv-NusA fusion protein in bacterial cytoplasm J. Biochem. 133 2003 577 581
206. Zimmerman S.C., and Lemcoff N.G. Synthetic hosts via molecular imprinting - are universal synthetic receptors realistically possible? Chem. Commun. 1 2004 5 14