Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display

Nature Biotechnology

Volumn 18, Issue 12, 2000, Pages 1287-1292

  Hanes, Jozef ^a,b   Schaffitzel, Christiane ^a   Knappik, Achim ^c   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Evotec Neurosciences GmbH   (Germany)

^c MORPHOSYS AG   (Germany)

Author keywords

Affinity maturation; Human Combinatorial Antibody Library; In vitro selection; Ribosome display; Single chain antibody fragments

Indexed keywords

ANTIBODY; INSULIN;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; DISSOCIATION CONSTANT; GENE LIBRARY; HUMAN; POINT MUTATION; PRIORITY JOURNAL; RIBOSOME; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY AFFINITY; CATTLE; CODON; DIRECTED MOLECULAR EVOLUTION; FRAMESHIFTING, RIBOSOMAL; IMMUNOGLOBULIN FRAGMENTS; INSULIN; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; RADIOIMMUNOPRECIPITATION ASSAY; RIBOSOMES; RNA, MESSENGER;

BOVINAE;

EID: 0033664270     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/82407     Document Type: Article

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