Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8437-8442

  Blanke, Steven R ^a,b   Milne, Jill C ^a   Benson, Ericka L ^a   Collier, R John ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; ARGININE; BACTERIAL ANTIGEN; DIPHTHERIA TOXIN; GLUTAMIC ACID; GLYCINE; HISTIDINE; HYBRID PROTEIN; LYSINE; PEPTIDE; POLYCATION; SERINE;

ANIMAL CELL; ARTICLE; BACILLUS ANTHRACIS; CHO CELL; CONTROLLED STUDY; CYTOSOL; INTRACELLULAR TRANSPORT; LETHAL GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT;

ADENOSINE DIPHOSPHATE RIBOSE; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; BIOLOGICAL TRANSPORT; CHO CELLS; CRICETINAE; CYTOSOL; DIPHTHERIA TOXIN; MOLECULAR SEQUENCE DATA; PEPTIDE ELONGATION FACTOR 2; PEPTIDE ELONGATION FACTORS; PEPTIDE FRAGMENTS; PEPTIDES; POLYLYSINE; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; ANTHRAX; BACILLUS ANTHRACIS; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0029758834     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8437     Document Type: Article

References (33)

1. Gill, D. M. (1978) in Bacterial Toxins and Cell Membranes, eds. Jeljaszewicz, J. & Wadstrom, T. (Academic, New York), pp. 291-332.
2. Considine, R. & Simpson, L. (1991) Toxicon 29, 913-936.
3. Leppla, S. H. (1982) Proc. Natl. Acad. Sci. USA 79, 3162-3166.
4. Hanna, P. C., Kochi, S. & Collier, R. J. (1992) Mol. Biol. Cell 3, 1269-1277.
5. Hanna, P. C., Acosta, D. & Collier, R. J. (1993) Proc. Natl. Acad. Sci. USA 90, 10198-10201.
6. Hanna, P. C., Kruskal, B. A., Ezekowitz, R. A. B., Bloom, B. R. & Collier, R. J. (1994) Mol. Med. 1, 7-18.
7. Leppla, S. H. (1995) in Bacterial Toxins and Virulence Factors in Disease, eds. Moss, J., Iglewski, B., Vaughan, M. & Tu, A. T. (Dekker, New York), pp. 543-572.
8. Escuyer, V. & Collier, R. J. (1991) Infect. Immun. 59, 3381-3386.
9. Klimpel, K. R., Molloy, S. S., Thomas, G. & Leppla, S. H. (1992) Proc. Natl. Acad. Sci. USA 89, 10277-10281.
10. Friedlander, A. M. (1986) J. Biol. Chem. 261, 7123-7126.
11. Gordon, V. M., Leppla, S. H. & Hewlett, E. L. (1988) Infect. Immun. 56, 1066-1069.
12. Blaustein, R. O., Koehler, T. M., Collier, R. J. & Finkelstein, A. (1989) Proc. Natl. Acad. Sci. USA 86, 2209-2213.
13. Koehler, T. M. & Collier, R. J. (1991) Mol. Microbiol. 5, 1501-1506.
14. Milne, J. C. & Collier, R. J. (1993) Mol. Microbiol. 10, 647-653.
15. Milne, J. C., Furlong, D., Hanna, P. C., Wall, J. S. & Collier, R. J. (1994) J. Biol. Chem. 269, 20607-20612.
16. Bragg, T. S. & Robertson, D. L. (1989) Gene 81, 45-54.
17. Labruyère, E., Mock, M., Ladant, D., Michelson, S., Gilles, A.-M., Laoide, B. & Bârzu, O. (1990) Biochemistry 29, 4922-4928.
18. Quinn, C. P., Singh, Y., Klimpel, K. R. & Leppla, S. H. (1991) J. Biol. Chem. 266, 20124-20130.
19. Arora, N. & Leppla, S. H. (1993) J. Biol. Chem. 268, 3334-3341.
20. Arora, N. & Leppla, S. H. (1994) Infect. Immun. 62, 4955-4961.
21. Arora, N., Williamson, L. C., Leppla, S. H. & Halpern, J. L. (1994) J. Biol. Chem. 269, 26165-26171.
22. Little, S. F., Leppla, S. H., Burnett, J. W. & Friedlander, A. M. (1994) Biochem. Biophys. Res. Commun. 199, 676-682.
23. Milne, J. C., Blanke, S. R., Hanna, P. C. & Collier, R. J. (1995) Mol. Microbiol. 15, 661-666.
24. Ausubel, F., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1987) Current Protocols in Molecular Biology (Wiley, New York).
25. Studier, F. W. & Moffatt, B. A. (1986) J. Mol. Biol. 189, 113-130.
26. Blanke, S. R., Huang, K., Wilson, B. A., Papini, E., Covacci, A. & Collier, R. J. (1994) Biochemistry 33, 5155-5161.
27. Leppla, S. H., Friedlander, A. M. & Cora, E. M. (1988) in Bacterial Protein Toxins, eds. Fehrenbach, F. J., Alouf, J. E., Goebel, W., Jeljaszewicz, J., Jurgen, D. & Rappuoli, R. (Fischer, Stuttgart, Germany), pp. 111-112.
28. Bhakdi, S. & Tranum-Jensen, J. (1985) Biochem. Soc. Symp. 50, 221-233.
29. Bhakdi, S. & Tranum-Jensen, J. (1987) Rev. Phys. Biochem. Pharmacol. 107, 147-223.
30. Bhakdi, S. & Tranum-Jensen, J. (1991) Microbiol Rev. 55, 733-751.
31. Wiedlocha, A., Madshus, I. H., Mach, H., Middaugh, C. R. & Olsnes, S. (1992) EMBO J. 11, 4835-4842.
32. Falnes, P. O., Choe, S., Madshus, I. H., Wilson, B. A. & Olsnes, S. (1994) J Biol. Chem. 269, 8402-8407.
33. Holmes, R. K., Jobling, M. G. & Connell, T. D. (1995) in Bacterial Toxins and Virulence Factors in Disease, eds. Moss, J., Iglewski, B., Vaughan, M. & Tu, A. T. (Dekker, New York), pp. 225-256.