Specificity rescue and affinity maturation of a low-affinity IgM antibody against pro-gastrin-releasing peptide using phage display and DNA shuffling

Tumor Biology

Volumn 25, Issue 1-2, 2004, Pages 7-13

  Fermér, Christian ^a   Andersson, Irma ^a   Nilsson, Karin ^a   Nilsson, Olle ^a  

^a Fujirebio Diagnostics Inc   (Sweden)

Author keywords

Affinity maturation; DNA shuffling; ELISA; Phage display; Single chain Fv; Tumor markers

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN M ANTIBODY; PEPTIDE; PROGASTRIN RELEASING PEPTIDE; RECOMBINANT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DNA SHUFFLING; HYBRIDOMA CELL CULTURE; MATERIALS; MATURATION; MOLECULAR CLONING; MOUSE; MUTAGENESIS; MUTANT; MUTATION; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; RANDOMIZATION; SEQUENCE ANALYSIS;

EID: 3042634329     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077717     Document Type: Article

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