Quantitative analysis of the effect of the mutation frequency on the affinity maturation of single chain Fv antibodies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 5, 2000, Pages 2029-2034

  Daugherty, Patrick S ^a,c   Chen, Gang ^b   Iverson, Brent L ^b   Georgiou, George ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CARDIAC GLYCOSIDE; DIGOXIGENIN; HAPTEN;

ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ARTICLE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTER; GENE LIBRARY; MUTATION RATE; NUCLEIC ACID BASE SUBSTITUTION; PHAGE DISPLAY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ASSAY;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; CLONING, MOLECULAR; GENE LIBRARY; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; SEQUENCE ANALYSIS;

ESCHERICHIA COLI;

EID: 0034049316     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.030527597     Document Type: Article

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