Mimicking somatic hypermutation: Affinity maturation of antibodies displayed on bacteriophage using a bacterial mutator strain

Journal of Molecular Biology

Volumn 260, Issue 3, 1996, Pages 359-368

  Low, Nigel M ^a   Holliger, Philipp ^b   Winter, Greg ^a,b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

Affinity maturation; Antibody; Mutagenesis; mutD5; Phage display

Indexed keywords

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; BACTERIOPHAGE; BINDING AFFINITY; CELL MUTANT; CONTROLLED STUDY; ESCHERICHIA COLI; GENEALOGY; NONHUMAN; PHAGE DISPLAY; POINT MUTATION; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE; SOMATIC MUTATION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FILAMENTOUS BACTERIOPHAGE;

EID: 0005229135     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0406     Document Type: Article

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