Glucose toxicity in β-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection

Diabetes

Volumn 52, Issue 3, 2003, Pages 581-587

  Robertson, R Paul ^a   Harmon, Jamie ^a   Tran, Phuong Oanh ^a   Tanaka, Yoshito ^a   Takahashi, Hiroki ^a  

^a PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

Author keywords

C Jun NH2 terminal kinase; DN, dominant negative; GCL, glutamylcysteine ligase; GPx, GSH peroxidase; GSH, glutathione; GSSG, oxidized GSH; JNK; PDX 1, pancreas duodenum homeobox 1; ROS, reactive oxygen species; SOD, superoxide dismutase

Indexed keywords

ACETYLCYSTEINE; ADENOVIRUS VECTOR; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA;

ANAEROBIC METABOLISM; ANTIOXIDANT ACTIVITY; AUTOOXIDATION; CELL FUNCTION; ENZYME ACTIVITY; GENE ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE THERAPY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOLYSIS; HOMEOBOX; HUMAN; HYPERGLYCEMIA; INSULIN SYNTHESIS; LONG TERM EXPOSURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS DUODENUM HOMEOBOX 1; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; REVIEW; STEM CELL TRANSPLANTATION; TOXICITY;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS, TYPE 2; GLUCOSE; GLUTATHIONE; HOMEODOMAIN PROTEINS; HUMANS; HYPERGLYCEMIA; INSULIN; ISLETS OF LANGERHANS; OXIDATIVE STRESS; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 0037341238     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.3.581     Document Type: Review

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