Insulin sensitivity, insulin secretion, and abdominal fat: The Insulin Resistance Atherosclerosis Study (IRAS) Family Study

Diabetes

Volumn 52, Issue 10, 2003, Pages 2490-2496

  Wagenknecht, Lynne E ^a   Langefeld, Carl D ^a   Scherzinger, Ann L ^b   Norris, Jill M ^b   Haffner, Steven M ^c   Saad, Mohammed F ^d   Bergman, Richard N ^e  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ABDOMEN; ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BODY FAT; BODY MASS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ETHNOLOGY; FAMILY STUDY; FEMALE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MODEL; OBESITY; PRIORITY JOURNAL; VERTEBRA;

ABDOMEN; ADIPOSE TISSUE; ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; GLUCOSE; HISPANIC AMERICANS; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0141755326     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.10.2490     Document Type: Article

References (39)

1. Despres JP: Abdominal obesity as important component of insulin-resistance syndrome. Nutrition 9:452-459, 1993
2. Chowdhury B, Sjöström L, Alpsten M, Kostanty J, Kvist H, Löfgren R: A multicompartment body composition technique based on computerized tomography. Int J Obes 18:219-234, 1994
3. Abate N, Garg A, Peshock RM, Stray-Gundersen J, Adams-Huet B, Grundy SM: Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes 45:1684-1693, 1996
4. Kelley DE, Thaete FL, Troost F, Huwe T, Goodpaster B: Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278:E941-E948, 2000
5. Frayn KN: Visceral fat and insulin resistance: causative or correlative? Br J Nutr 83 (Suppl. 1):S71-S77, 2000
6. Bergman RN, Ader M, Huecking K, Van Citters G: Accurate assessment of β-cell function: the hyperbolic correction. Diabetes 51 (Suppl. 1):S212-S220, 2002
7. Henkin L, Bergman RN, Bowden DW, Ellsworth DL, Haffner SM, Langefeld CD, Mitchell BD, Norris JM, Rewers M, Saad MF, Stamm E, Wagenknecht LE, Rich SS: Genetic epidemiology of insulin resistance and visceral adiposity: the IRAS Family Study design and methods. Ann Epidemiol 13:211-217, 2003
8. Wagenknecht LE, Mayer E, Rewers M, Haffner S, Selby J, Borok GM, Henkin L, Howard G, Savage PJ, Saad M, Bergman RN, Hamman R: The Insulin Resistance Atherosclerosis Study (IRAS): objectives, design and recruitment results. Ann Epidemiol 5:464-472, 1995
9. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-86, 1985
10. Pacini G, Bergman RN: MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsitivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23:113-122, 1986
11. Welch S, Gebhart SSP, Bergman RN, Phillips LS: Minimal model analysis of intravenous glucose tolerance derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518, 1990
12. Steil GM, Volund A, Kahn SE, Bergman RN: Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model: suitability for use in population studies. Diabetes 42:250-256, 1993
13. Herbert V, Lau K, Gottlieb C, Bleicher S: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384, 1965
14. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK: Hyperinsulinenua in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med 315:220-224, 1986
15. Hamman RF, Marshall JA, Baxter J, Kahn LB, Mayer EJ, Orleans MM, Murphy JR, Lezotte DC: Methods and prevalence of non-insulin-dependent diabetes mellitus in a biethnic Colorado population. Am J Epidemiol 129:295-311, 1989
16. Stern MP, Rosenthal M, Haffner SM, Hazuda HP, Franco LJ: Sex differences in the effects of sociocultural status on diabetes and cardiovascular risk factors in Mexican Americans. Am J Epidemiol 120:834-851, 1984
17. Cox DR, Snell EJ: Analysis of Binary Data. 2nd ed. London, Chapman & Hall, 1989
18. Bonora E: Relationship between regional fat distribution and insulin resistance. Int J Obes 24 (Suppl. 2):S32-S35, 2000
19. Albu JB, Murphy L, Frager DH, Johnson JA, Pi-Sunyer F: Visceral fat and race-dependent health risks in obese nondiabetic premenopausal women. Diabetes 46:456-462, 1997
20. Macor C, Ruggeri A, Mazzonetto P, Federspil G, Cobelli C, Vettor R: Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity. Metabolism 46:123-129, 1997
21. Goodpaster BH, Thaete FL, Simoneau J-A, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585, 1997
22. Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE: The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51:1005-1015, 2002
23. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL: Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847, 1999
24. Sumner AE, Farmer NM, Cochran CS, Sebring NG, Vanevski K, Reynolds JC, Premkumar A, Boston RC: Obese premenopausal African-American women with normal and impaired glucose tolerance have a similar degree of insulin resistance but differ in β-cell function. Diabetes Care 24:1978-1983, 2001
25. Cruz ML, Bergman RN, Goran MI: Unique effect of visceral fat on insulin sensitivity in obese Hispanic children with a family history of type 2 diabetes. Diabetes Care 25:1631-1636, 2002
26. Goran MI, Bergman RN, Gower BA: Influence of total vs visceral fat on insulin action and secretion in African American and white children. Obes Res 9:423-431, 2001
27. Boyko EJ, Fujimoto WY, Leonetti DL, Newell-Morris L: Visceral adiposity and risk of type 2 diabetes: a prospective study among Japanese Americans. Diabetes Care 23:46.5-471, 2000
28. Mittelman SD, Van Citters GW, Kim SP, Davis DA, Dea MK, Hamilton-Wessler M, Bergman RN: Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β-cell response. Diabetes 49:2116-2125, 2000
29. Weyer C, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
30. Karter AJ, Mayer-Davis EJ, Selby JV, D'Agostino RB Jr, Haffner SM, Sholinsky P, Bergman R, Saad MF, Hamman RF: Insulin sensitivity and abdominal obesity in African American, Hispanic, and non-Hispanic white men and women: the Insulin Resistance and Atherosclerosis Study. Diabetes 45:1547-1555, 1996
31. Haffner SM, D'Agostino R Jr, Saad MF, Rewers M, Mykkanen L, Selby J, Howard G, Savage PJ, Hamman RF, Wagenknecht LE, Bergman RN: Increased insulin resistance and insulin secretion in nondiabetic African-Americans and Hispanics compared with non-Hispanic whites: the Insulin Resistance Atherosclerosis Study. Diabetes 45:742-748, 1996
32. Bonora E, Del Prato S, Bonadonna R, Gulli G, Solini A, Shank M, Ghiatas A, Lancaster J, Kilcoyne R, Alyassin A, DeFronzo R: Total body fat content and fat topography are associated differently with in vivo glucose metabolism in nonobese and obese nondiabetic women. Diabetes 41:1151-1159, 1992
33. Arner P: Insulin resistance in type 2 diabetes: role of fatty acids. Diabete Metab Res Rev 18 (Suppl. 2):S5-S9, 2002
34. Johnson JA, Fried SK, Pi-Sunyer FX, Albu JB: Impaired insulin action in subcutaneous adipocytes from women with visceral adiposity. Am J Physiol Endocrinol Metab 280: E40-E49, 2001
35. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409-2415, 1995
36. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79-83, 1999
37. Chen M, Bergman RN, Pacini G, Porte D Jr: Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab 60:13-20, 1985
38. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH: The disease burden associated with overweight and obesity. JAMA 282:1523-1529, 1999
39. Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, Wiedmeyer H-M, Byrd-Holt DD: Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: the Third National Health and Nutrition Examination Survey 1988-1994. Diabetes Care 21:518-524, 1998