Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways

Diabetologia

Volumn 47, Issue 11, 2004, Pages 1998-2011

  Karlsen, A E ^a   Heding, P E ^a   Frobose H ^a   Ronn S G ^a   Kruhoffer M ^b   Orntoft T F ^b   Darville, M ^c   Eizirik, D L ^c   Pociot, F ^a   Nerup, J ^a   Mandrup Poulsen, T ^a,d   Billestrup, N ^a  

^a STENO DIABETES CENTER   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c FREE UNIVERSITY OF BRUSSELS   (Belgium)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Autoimmunity; Beta cells; Cell signalling; Cytokines; IL 1 ; Nitric oxide synthase

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; DNA MICROARRAY; EARLY RESPONSE GENE; ENERGY METABOLISM; ENZYME INHIBITION; EXPRESSED SEQUENCE TAG; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; GENE EXPRESSION REGULATION; INTERLEUKIN-1; NF-KAPPA B; NITRIC OXIDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS;

EID: 19944429062     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1568-3     Document Type: Article

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