A radical explanation for glucose-induced β cell dysfunction

Journal of Clinical Investigation

Volumn 112, Issue 12, 2003, Pages 1788-1790

  Brownlee, Michael ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; FLAVINE ADENINE NUCLEOTIDE; FREE RADICAL; GLUCOSE; INSULIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; TRANSCRIPTION FACTOR PDX 1; TRICARBOXYLIC ACID; UBIQUINONE; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 2;

DIABETES MELLITUS; ELECTRON TRANSPORT; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; REVIEW;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD GLUCOSE; GLUCOSE; HUMANS; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; PANCREATIC DISEASES; SUPEROXIDES;

EID: 0346093889     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200320501     Document Type: Review

References (17)

1. Cowie, C.C., et al. 2003. Prevalence of diabetes and impaired fasting glucose in adults: United States, 1999-2000. JAMA. 290:1702-1703.
2. Narayan, K.M., et al. 2003. Lifetime risk for diabetes mellitus in the United States. JAMA. 290:1884-1890.
3. Norhammar, A., et al. 2002. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet. 360:2140-2144.
4. National Diabetes Data Group. 1995. Diabetes in America. 2nd edition. Bethesda, Maryland, USA. NIH Publication no. 95-1468.1-730.
5. Minokoshi, Y., et al. 2003. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J. Biol. Chem. 278:33609-33612.
6. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N. Engl. J. Med. 329:977-986.
7. Gerich, J.E., and Smith, T.S. 2003. β-Cell defects and pancreatic abnormalities in type 2 diabetes. In Textbook of diabetes. 3rd edition. J.C. Pickup and G. Williams, editors. Blackwell Science. Oxford, United Kingdom. 23.1-23.11.
8. Robertson, R.P., et al. 2003. Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes. 52:581-587.
9. Knowler, W.C., et al. 2002. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346:393-403.
10. Maechler, P., and Woheim, C.B. 2001. Mitochondrial function in normal and diabetic β-cells. Nature. 414:807-812.
11. Zhang, C.-Y., et al. 2001. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes. Cell. 105:745-755.
12. Polonsky, K.S., and Semenkovich, C.F. 2001. The pancreatic β-cell heats up: UCP2 and insulin secretion in diabetes. Cell. 105:705-707.
13. Krauss, S., et al. 2003. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J. Clin. Invest. 112:1831-1842. doi:10.1172/JCI200319774.
14. Echtay, K.S., et al. 2002. Superoxide activates mitochondrial uncoupling proteins. Nature. 415:96-99.
15. Brownlee, M. 2001. Biochemistry and molecular cell biology of diabetic complications. Nature. 414:813-820.
16. Du, X., et al. 2003. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J. Clin. Invest. 112:1049-1057. doi:10.1172/JCI200318127.
17. Maechler, P., and Wollheim, C.B. 2001. Mitochondrial function in normal and diabetic β-cells. Nature. 414:807-812.