-
1
-
-
0021875480
-
In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis
-
Bottazzo, G.F., et al. 1985. In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. 313:353-360.
-
(1985)
N. Engl. J. Med.
, vol.313
, pp. 353-360
-
-
Bottazzo, G.F.1
-
2
-
-
0000836601
-
Roles of cytokines in IDDM pathogenesis and islet β-cell destruction
-
Rabinovitch, A. 1993. Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Reviews. 1:215-240.
-
(1993)
Diabetes Reviews
, vol.1
, pp. 215-240
-
-
Rabinovitch, A.1
-
3
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen, T. 1996. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia. 39:1005-1029.
-
(1996)
Diabetologia
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, T.1
-
4
-
-
0029922661
-
Cytokine gene expression in pancreatic islet-infiltration leukocytes of BB rats: Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM
-
Rabinovitch, A., Suarez-Pinzon, W., El Seikh, A., Sorensen, O., and Power, R.F. 1996. Cytokine gene expression in pancreatic islet-infiltration leukocytes of BB rats: expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM. Diabetes. 45:749-754.
-
(1996)
Diabetes
, vol.45
, pp. 749-754
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.2
El Seikh, A.3
Sorensen, O.4
Power, R.F.5
-
5
-
-
0025817159
-
Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat
-
Jiang, Z., and Woda, B. A. 1991. Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat. J. Immunology. 146:2990-2994.
-
(1991)
J. Immunology
, vol.146
, pp. 2990-2994
-
-
Jiang, Z.1
Woda, B.A.2
-
6
-
-
0030903103
-
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
-
Hirasawa, K., et al. 1997. Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice. J. Virol. 71:4024-4031.
-
(1997)
J. Virol.
, vol.71
, pp. 4024-4031
-
-
Hirasawa, K.1
-
7
-
-
0023520177
-
Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus
-
Foulis, A.K., Farquharson, M.A., and Meager, A. 1987. Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet. 2:1423-1427.
-
(1987)
Lancet
, vol.2
, pp. 1423-1427
-
-
Foulis, A.K.1
Farquharson, M.A.2
Meager, A.3
-
8
-
-
0025951776
-
Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: Macrophages, lymphocytes, and interferon-g containing cells
-
Foulis, A.K., McGill, M., and Farquharson, M.A. 1991. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: macrophages, lymphocytes, and interferon-g containing cells. J. Pathol. 165:97-103.
-
(1991)
J. Pathol.
, vol.165
, pp. 97-103
-
-
Foulis, A.K.1
McGill, M.2
Farquharson, M.A.3
-
9
-
-
0029036567
-
Interferon expression in the pancreases of patients with type I diabetes
-
Huang, X., et al. 1995. Interferon expression in the pancreases of patients with type I diabetes. Diabetes. 44:658-664.
-
(1995)
Diabetes
, vol.44
, pp. 658-664
-
-
Huang, X.1
-
10
-
-
0030030135
-
Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM
-
Hussain, M.J., Peakman, M., and Gallati, H. 1996. Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM. Diabetologia. 39:60-69.
-
(1996)
Diabetologia
, vol.39
, pp. 60-69
-
-
Hussain, M.J.1
Peakman, M.2
Gallati, H.3
-
11
-
-
0030923812
-
Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
-
Delaney, C.A., Pavlovic, D., Hoorens, A., Pipeleers, D., and Eizirik, D.L. 1997. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology. 138:2610-2614.
-
(1997)
Endocrinology
, vol.138
, pp. 2610-2614
-
-
Delaney, C.A.1
Pavlovic, D.2
Hoorens, A.3
Pipeleers, D.4
Eizirik, D.L.5
-
12
-
-
0028607474
-
Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses
-
Ræder, M.E., et al. 1994. Disproportionately elevated proinsulin levels precede the onset of insulin-dependent diabetes mellitus in siblings with low first phase insulin responses. J. Clin. Endoctrinol. Metab. 79:1570-1575.
-
(1994)
J. Clin. Endoctrinol. Metab.
, vol.79
, pp. 1570-1575
-
-
Ræder, M.E.1
-
13
-
-
0026585133
-
Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients
-
Spinas, G.A., Snorgaard, O., Hartling, S.G., Oberholzer, M., and Berger, W. 1992. Elevated proinsulin levels related to islet cell antibodies in first-degree relatives of IDDM patients. Diabetes Care. 15:632-637.
-
(1992)
Diabetes Care
, vol.15
, pp. 632-637
-
-
Spinas, G.A.1
Snorgaard, O.2
Hartling, S.G.3
Oberholzer, M.4
Berger, W.5
-
14
-
-
0024435846
-
Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity
-
Hartling, S.G., Lindgren, F., Dahlqvist, G., Persson, B., and Binder, B. 1989. Elevated proinsulin in healthy siblings of IDDM patients independent of HLA identity. Diabetes. 38:1271-1274.
-
(1989)
Diabetes
, vol.38
, pp. 1271-1274
-
-
Hartling, S.G.1
Lindgren, F.2
Dahlqvist, G.3
Persson, B.4
Binder, B.5
-
15
-
-
0023932360
-
Increased proinsulin Levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients
-
Heaton, D.A., et al. 1988. Increased proinsulin Levels as an early indicator of β-cell dysfunction in non-diabetic twins of type 1 (insulin-dependent) diabetic patients. Diabetologia. 31:182-184.
-
(1988)
Diabetologia
, vol.31
, pp. 182-184
-
-
Heaton, D.A.1
-
16
-
-
6844239526
-
Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: Graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
-
Keymeulen, B., et al. 1998. Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia. 41:452-459.
-
(1998)
Diabetologia
, vol.41
, pp. 452-459
-
-
Keymeulen, B.1
-
17
-
-
0030467497
-
Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading ro a loss of glucose regulation
-
Ling, Z., and Pipeleers, D. 1996. Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading ro a loss of glucose regulation. J. Clin. Invest. 98:2805-2812.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2805-2812
-
-
Ling, Z.1
Pipeleers, D.2
-
18
-
-
0028296629
-
Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
-
Eizirik, D.L., et al. 1994. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin. Invest. 93:1968-1974.
-
(1994)
J Clin. Invest.
, vol.93
, pp. 1968-1974
-
-
Eizirik, D.L.1
-
19
-
-
0025685395
-
Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an 1-arginine dependent nitric oxide generating mechanism
-
Southern, C., Schulster, D., and Green, I.C. 1990. Inhibition of insulin secretion by interleukin-1β and tumor necrosis factor-α via an 1-arginine dependent nitric oxide generating mechanism. FEBS Lett. 276:42-44.
-
(1990)
FEBS Lett.
, vol.276
, pp. 42-44
-
-
Southern, C.1
Schulster, D.2
Green, I.C.3
-
20
-
-
0020448709
-
15N)nitrate in biological fluids
-
15N)nitrate in biological fluids. Anal. Biochem. 126:131-138.
-
(1982)
Anal. Biochem.
, vol.126
, pp. 131-138
-
-
Green, L.1
-
21
-
-
0031763798
-
Effect of glucose on production and release of proinsulin conversion products by cultured human islets
-
Zambre, Y., et al. 1998. Effect of glucose on production and release of proinsulin conversion products by cultured human islets. J. Clin. Endocrinol. Metab. 83:1234-1238.
-
(1998)
J. Clin. Endocrinol. Metab.
, vol.83
, pp. 1234-1238
-
-
Zambre, Y.1
-
22
-
-
0026593276
-
Differences in glucose recognition by individual rat pancreatic ß cells are associated wirh intercellular differences in glucose-induced biosynthetic activity
-
Kiekens, R., et al. 1992. Differences in glucose recognition by individual rat pancreatic ß cells are associated wirh intercellular differences in glucose-induced biosynthetic activity. J Clin. Invest. 89:117-125.
-
(1992)
J Clin. Invest.
, vol.89
, pp. 117-125
-
-
Kiekens, R.1
-
23
-
-
0021885620
-
Interplay of nutrients and hormones in the regulation of insulin release
-
Pipeleers, D.G., et al. 1985. Interplay of nutrients and hormones in the regulation of insulin release. Endocrinology. 117:824-833.
-
(1985)
Endocrinology
, vol.117
, pp. 824-833
-
-
Pipeleers, D.G.1
-
24
-
-
0026787567
-
A rapid and sensitive radi oimmunoassay for the measurement of proinsulin in human serum
-
Bowsher, R.R., Wolny, J.D., and Frank, B.H. 1992. A rapid and sensitive radi oimmunoassay for the measurement of proinsulin in human serum. Diabetes. 41:1084-1090.
-
(1992)
Diabetes
, vol.41
, pp. 1084-1090
-
-
Bowsher, R.R.1
Wolny, J.D.2
Frank, B.H.3
-
25
-
-
0031766627
-
Intercellular differences in interleukin 1β-induced suppression of insulin synthesis and stimulation of non-insulin protein synthesis by rat pancreatic α cells
-
Ling, Z., et al. 1998. Intercellular differences in interleukin 1β-induced suppression of insulin synthesis and stimulation of non-insulin protein synthesis by rat pancreatic α cells. Endocrinology. 139:1540-1545.
-
(1998)
Endocrinology
, vol.139
, pp. 1540-1545
-
-
Ling, Z.1
-
26
-
-
0002252319
-
Design of suitable primers and competitor fragments for quantitative PCR
-
D. Laßner, A-K. Rost, B. Thamm, B. Pustowoit, and H. Remke, editors, Springer-Verlag, Berlin, Germany.
-
Köhler, T. 1995. Design of suitable primers and competitor fragments for quantitative PCR. In Quantitation of mRNA by polymerase chain reaction: nonradioactive PCR methods. D. Laßner, A-K. Rost, B. Thamm, B. Pustowoit, and H. Remke, editors, Springer-Verlag, Berlin, Germany. 15-24.
-
(1995)
Quantitation of Mrna by Polymerase Chain Reaction: Nonradioactive Pcr Methods
, pp. 15-24
-
-
Köhler, T.1
-
27
-
-
0028912883
-
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin dependent diabetes mellitus
-
Alarcon, C., Leahy, J.L., Schuppin, G.T., and Rhodes, C.J. 1995. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin dependent diabetes mellitus. J. Clin. Invest. 95:1032-1039.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1032-1039
-
-
Alarcon, C.1
Leahy, J.L.2
Schuppin, G.T.3
Rhodes, C.J.4
-
28
-
-
0029091212
-
Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β cell
-
Gadot, M., Ariav, Y., Cerasi, E., Kaiser, N., and Gross, D.J. 1995. Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β cell. Endocrinology. 136:4218-4223.
-
(1995)
Endocrinology
, vol.136
, pp. 4218-4223
-
-
Gadot, M.1
Ariav, Y.2
Cerasi, E.3
Kaiser, N.4
Gross, D.J.5
-
29
-
-
0030040425
-
Hyperproinsulinemia is associated with increased β cell demand after hemipancrearecromy in humans
-
Seaquist, E.Z., et al. 1996. Hyperproinsulinemia is associated with increased β cell demand after hemipancrearecromy in humans. J. Clin. Invest. 97:455-460.
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 455-460
-
-
Seaquist, E.Z.1
-
30
-
-
0028230040
-
What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
-
Rhodes, C.J., and Alarcon, C. 1994. What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes. 43:511-517.
-
(1994)
Diabetes
, vol.43
, pp. 511-517
-
-
Rhodes, C.J.1
Alarcon, C.2
-
31
-
-
0030470658
-
Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure
-
Gross, D.J., Leibowitz, G., Cerasi, E., and Kaiser, N. 1996. Increased susceptibility of islets from diabetes-prone Psammomys obesus to the deleterious effects of chronic glucose exposure. Endocrinology. 137:5610-5615.
-
(1996)
Endocrinology
, vol.137
, pp. 5610-5615
-
-
Gross, D.J.1
Leibowitz, G.2
Cerasi, E.3
Kaiser, N.4
|