메뉴 건너뛰기




Volumn 98, Issue 12, 1996, Pages 2805-2812

Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

Author keywords

diabetes; glucose; insulin; islets

Indexed keywords

GLUCOSE; INSULIN;

EID: 0030467497     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119108     Document Type: Article
Times cited : (173)

References (34)
  • 1
    • 0002678511 scopus 로고
    • Pathogenesis of non-insulin-dependent (type II) diabetes mellitus
    • C.R. Hahn and G.C. Weir, editors. Lea & Febiger, Malvern, PA
    • Weir, G.C., and J.L. Leahy. 1994. Pathogenesis of non-insulin-dependent (type II) diabetes mellitus. In Joslin's Diabetes Mellitus, 13th. C.R. Hahn and G.C. Weir, editors. Lea & Febiger, Malvern, PA. 240-264.
    • (1994) Joslin's Diabetes Mellitus, 13th. , pp. 240-264
    • Weir, G.C.1    Leahy, J.L.2
  • 2
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Järvinen, H. 1992. Glucose toxicity. Endocr. Rev. 13:415-431.
    • (1992) Endocr. Rev. , vol.13 , pp. 415-431
    • Yki-Järvinen, H.1
  • 4
    • 0025142898 scopus 로고
    • Natural history of β-cell dysfunction in NIDDM
    • Leahy, J.L. 1990. Natural history of β-cell dysfunction in NIDDM. Diabetes Care. 13:992-1010.
    • (1990) Diabetes Care , vol.13 , pp. 992-1010
    • Leahy, J.L.1
  • 5
    • 0028000563 scopus 로고
    • Differentiating glucose toxicity from glucose desensitization: A new message from the insulin gene
    • Robertson, R.P., L.K. Olson, and H.J. Zhang. 1994. Differentiating glucose toxicity from glucose desensitization: a new message from the insulin gene. Diabetes. 43:1085-1089.
    • (1994) Diabetes , vol.43 , pp. 1085-1089
    • Robertson, R.P.1    Olson, L.K.2    Zhang, H.J.3
  • 6
    • 0024351557 scopus 로고
    • Type II diabetes, glucose "non-sense," and islet desensitization
    • Robertson, R.P. 1989. Type II diabetes, glucose "non-sense," and islet desensitization. Diabetes. 38:1501-1505.
    • (1989) Diabetes , vol.38 , pp. 1501-1505
    • Robertson, R.P.1
  • 7
    • 0021220641 scopus 로고
    • Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass
    • Leahy, J.L., S. Bonner-Weir, and G.C. Weir. 1984. Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass. Diabetes. 33:667-673.
    • (1984) Diabetes , vol.33 , pp. 667-673
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 8
    • 0022522943 scopus 로고
    • Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: A study in normal rats using chronic in vivo glucose infusions
    • Leahy, J.L., H.E. Cooper, D.A. Deal, and G.C. Weir. 1986. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion: a study in normal rats using chronic in vivo glucose infusions. J. Clin. Invest. 77:908-915.
    • (1986) J. Clin. Invest. , vol.77 , pp. 908-915
    • Leahy, J.L.1    Cooper, H.E.2    Deal, D.A.3    Weir, G.C.4
  • 9
    • 0020636495 scopus 로고
    • Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release
    • Bonner-Weir, S., D.F. Trent, and G.C. Weir. 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Invest. 71:1544-1553.
    • (1983) J. Clin. Invest. , vol.71 , pp. 1544-1553
    • Bonner-Weir, S.1    Trent, D.F.2    Weir, G.C.3
  • 10
    • 0025600472 scopus 로고
    • Hyperglycemia-induced B-cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background
    • Korsgren, O., J. Jansson, S. Sandler, and A. Andersson. 1990. Hyperglycemia-induced B-cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J. Clin. Invest. 86:2161-2168.
    • (1990) J. Clin. Invest. , vol.86 , pp. 2161-2168
    • Korsgren, O.1    Jansson, J.2    Sandler, S.3    Andersson, A.4
  • 11
    • 0029146542 scopus 로고
    • Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice
    • Jansson, L., D.L. Eizirik, D.G. Pipeleers, L.A.H. Borg, C. Hellerström, and A. Andersson. 1995. Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J. Clin. Invest. 93:721-726.
    • (1995) J. Clin. Invest. , vol.93 , pp. 721-726
    • Jansson, L.1    Eizirik, D.L.2    Pipeleers, D.G.3    Borg, L.A.H.4    Hellerström, C.5    Andersson, A.6
  • 12
    • 0023947320 scopus 로고
    • Characteristics of desensitization of insulin secretion in fully in vitro system
    • Bolaffi, J.L., L. Bruno, A. Heldt, and G.M. Grodsky. 1988 Characteristics of desensitization of insulin secretion in fully in vitro system. Endocrinology. 122:1801-1809.
    • (1988) Endocrinology , vol.122 , pp. 1801-1809
    • Bolaffi, J.L.1    Bruno, L.2    Heldt, A.3    Grodsky, G.M.4
  • 13
    • 0026607455 scopus 로고
    • Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: Evidence supporting specific desensitization rather than β-cell exhaustion
    • Davalli, A.M., A.E. Pontiroli, C. Socci, F. Bertuzzi, B. Fattor, S. Braghi, V. Di Carlo, and G. Pozza. 1992. Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: evidence supporting specific desensitization rather than β-cell exhaustion. J. Clin. Endocrinol. & Metab. 74:790-794.
    • (1992) J. Clin. Endocrinol. & Metab. , vol.74 , pp. 790-794
    • Davalli, A.M.1    Pontiroli, A.E.2    Socci, C.3    Bertuzzi, F.4    Fattor, B.5    Braghi, S.6    Di Carlo, V.7    Pozza, G.8
  • 14
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function
    • Eizirik, D.L., G.S. Korbutt, and C. Hellerström. 1992. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J. Clin. Invest. 90:1263-1268.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1263-1268
    • Eizirik, D.L.1    Korbutt, G.S.2    Hellerström, C.3
  • 15
    • 0024451490 scopus 로고
    • Effects of high glucose on insulin secretion by isolated rat islets and purified β-cells and possible role of glycosylation
    • Purrello, F., M. Vetri, C. Gatta, D. Gullo, and R. Vigneri. 1989. Effects of high glucose on insulin secretion by isolated rat islets and purified β-cells and possible role of glycosylation. Diabetes. 38:1417-1422.
    • (1989) Diabetes , vol.38 , pp. 1417-1422
    • Purrello, F.1    Vetri, M.2    Gatta, C.3    Gullo, D.4    Vigneri, R.5
  • 16
    • 0027385108 scopus 로고
    • Beta cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats
    • Leahy, J.L., M. Bumbalo, and C. Chen. 1993. Beta cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats. Diabetologia. 36:1238-1244.
    • (1993) Diabetologia , vol.36 , pp. 1238-1244
    • Leahy, J.L.1    Bumbalo, M.2    Chen, C.3
  • 17
    • 0027155312 scopus 로고
    • In vivo and vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period
    • Thibault, C., C. Guettet, M.C. Laury, J.M. N'Guyen, T.A. Tormo, B. Portha, L. Pénicaud, and A. Ktorza. 1993. In vivo and vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period. Diabetologia. 36:589-595.
    • (1993) Diabetologia , vol.36 , pp. 589-595
    • Thibault, C.1    Guettet, C.2    Laury, M.C.3    N'Guyen, J.M.4    Tormo, T.A.5    Portha, B.6    Pénicaud, L.7    Ktorza, A.8
  • 18
    • 0022550168 scopus 로고
    • In vitro exhaustion of pancreatic β-cells
    • Endocrinol. Metab. 13
    • Hoenig, M., L.C. MacGregor, and F.M. Matschinsky. 1986. In vitro exhaustion of pancreatic β-cells. Am. J. Physiol. 250 (Endocrinol. Metab. 13): E502-E511.
    • (1986) Am. J. Physiol. , vol.250
    • Hoenig, M.1    MacGregor, L.C.2    Matschinsky, F.M.3
  • 21
    • 0026651708 scopus 로고
    • Heterogeneity in pancreatic β-cell population
    • Pipeleers, D. 1992. Heterogeneity in pancreatic β-cell population. Diabetes. 41:777-781.
    • (1992) Diabetes , vol.41 , pp. 777-781
    • Pipeleers, D.1
  • 22
    • 0028095283 scopus 로고
    • Physiologic relevance of heterogeneity in pancreatic β cell population
    • Pipeleers, D., R. Kiekens, Z. Ling, A. Wilikens, and F. Schuit. 1994. Physiologic relevance of heterogeneity in pancreatic β cell population. Diabetologia. 37(Suppl. 2):S57-S64.
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Pipeleers, D.1    Kiekens, R.2    Ling, Z.3    Wilikens, A.4    Schuit, F.5
  • 23
    • 0039829851 scopus 로고    scopus 로고
    • Glucose stimulated proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
    • Schuit, F.C., P.A. In't Veld, and D.G. Pipeleers. 1996. Glucose stimulated proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc. Natl. Acad. Sci. USA. 85:3865-3869.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3865-3869
    • Schuit, F.C.1    In't Veld, P.A.2    Pipeleers, D.G.3
  • 24
    • 0026593276 scopus 로고
    • Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity
    • Kiekens, R., P.A. In't Veld, T. Mahler, F.C. Schuit, M. Van De Winkel, and D.G. Pipeleers. 1991. Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity, J. Clin. Invest. 89:117-125.
    • (1991) J. Clin. Invest. , vol.89 , pp. 117-125
    • Kiekens, R.1    In't Veld, P.A.2    Mahler, T.3    Schuit, F.C.4    Van De Winkel, M.5    Pipeleers, D.G.6
  • 25
    • 0024496120 scopus 로고
    • Viable purified islets of Langerhans from collagenase-perfused human pancreas
    • Warnock, G.L., D.K. Ellis, M. Cattral, D. Untch, N.M. Kneteman, and R.V. Rajotte. 1989. Viable purified islets of Langerhans from collagenase-perfused human pancreas. Diabetes. 38(Suppl. 1):136-139.
    • (1989) Diabetes , vol.38 , Issue.1 SUPPL. , pp. 136-139
    • Warnock, G.L.1    Ellis, D.K.2    Cattral, M.3    Untch, D.4    Kneteman, N.M.5    Rajotte, R.V.6
  • 27
    • 0013492650 scopus 로고
    • Pancreatic B cells possess defense mechanism against cell-specific toxicity
    • Pipeleers, D.G., and M. Van De Winkel. 1986. Pancreatic B cells possess defense mechanism against cell-specific toxicity. Proc. Natl. Acad. Sci. USA. 83:5267-5271.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5267-5271
    • Pipeleers, D.G.1    Van De Winkel, M.2
  • 28
    • 0026803423 scopus 로고
    • Pancreatic β cell heterogeneity in glucose-induced insulin secretion
    • Van Schravendijk, C., R. Kiekens, and D.G. Pipeleers. 1992. Pancreatic β cell heterogeneity in glucose-induced insulin secretion. J. Biol. Chem. 25:21344-21348.
    • (1992) J. Biol. Chem. , vol.25 , pp. 21344-21348
    • Van Schravendijk, C.1    Kiekens, R.2    Pipeleers, D.G.3
  • 29
    • 0028318109 scopus 로고
    • Preservation of glucose-responsive islet beta cells during serum-free culture
    • Ling, Z., and D.G. Pipeleers. 1994. Preservation of glucose-responsive islet beta cells during serum-free culture. Endocrinology. 134:2614-2621.
    • (1994) Endocrinology , vol.134 , pp. 2614-2621
    • Ling, Z.1    Pipeleers, D.G.2
  • 31
    • 0025182175 scopus 로고
    • β-cell hyperresponsiveness: Earliest event in the development of diabetes in monkeys
    • Hansen, B.C., and N.L. Bodkin. 1990. β-cell hyperresponsiveness: earliest event in the development of diabetes in monkeys. Am. J. Physiol. 259:R612-R617.
    • (1990) Am. J. Physiol. , vol.259
    • Hansen, B.C.1    Bodkin, N.L.2
  • 32
    • 0016354383 scopus 로고
    • Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture
    • Andersson, A., J. Westman, and C. Hellerström. 1974. Effects of glucose on the ultrastructure and insulin biosynthesis of isolated mouse pancreatic islets maintained in tissue culture. Diabetologia. 10:743-753.
    • (1974) Diabetologia , vol.10 , pp. 743-753
    • Andersson, A.1    Westman, J.2    Hellerström, C.3
  • 33
    • 0026625602 scopus 로고
    • Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture
    • Liang, Y., H. Najafi, R.M. Smith, B.C. Zimmol/Lerman, M.A. Magnuson, M. Tal, and F.M. Matschinsky. 1992. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes. 41:792-806.
    • (1992) Diabetes , vol.41 , pp. 792-806
    • Liang, Y.1    Najafi, H.2    Smith, R.M.3    Zimmol Lerman, E.C.4    Magnuson, M.A.5    Tal, M.6    Matschinsky, F.M.7
  • 34
    • 0027391166 scopus 로고
    • Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic β-cells
    • Purrello, F., M. Buscema, A.M. Rabuazzo, V. Caltabiano, F. Forte, C. Vinci, M. Vetri, and R. Vigneri. 1993. Glucose modulates glucose transporter affinity, glucokinase activity, and secretory response in rat pancreatic β-cells. Diabetes. 42:199-205.
    • (1993) Diabetes , vol.42 , pp. 199-205
    • Purrello, F.1    Buscema, M.2    Rabuazzo, A.M.3    Caltabiano, V.4    Forte, F.5    Vinci, C.6    Vetri, M.7    Vigneri, R.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.