메뉴 건너뛰기




Volumn 348, Issue 14, 2003, Pages 1365-1375

Apoptosis and caspases in neurodegenerative diseases

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 11; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MINOCYCLINE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

EID: 0037417220     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMra022366     Document Type: Review
Times cited : (798)

References (98)
  • 1
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J, Yankner BA. Apoptosis in the nervous system. Nature 2000;407:802-9.
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 2
    • 0036581270 scopus 로고    scopus 로고
    • Neural stem cell therapy for neurological diseases: Dreams and reality
    • Rossi F, Cattaneo E. Neural stem cell therapy for neurological diseases: dreams and reality. Nat Rev Neurosci 2002;3:401-9.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 401-409
    • Rossi, F.1    Cattaneo, E.2
  • 5
    • 0032189609 scopus 로고    scopus 로고
    • Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils
    • Liu J, Solway K, Messing RO, Sharp FR. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 1998;18:7768-78.
    • (1998) J Neurosci , vol.18 , pp. 7768-7778
    • Liu, J.1    Solway, K.2    Messing, R.O.3    Sharp, F.R.4
  • 6
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 8
    • 0036651535 scopus 로고    scopus 로고
    • Cell death: Apoptosis versus necrosis
    • Kanduc D, Mittelman A, Serpico, R, et al. Cell death: apoptosis versus necrosis. Int J Oncol 2002;21:165-70.
    • (2002) Int J Oncol , vol.21 , pp. 165-170
    • Kanduc, D.1    Mittelman, A.2    Serpico, R.3
  • 9
    • 0035348408 scopus 로고    scopus 로고
    • Neuronal cell death in nervous system development, disease, and injury
    • Martin LJ. Neuronal cell death in nervous system development, disease, and injury. Int J Mol Med 2001;7:455-78.
    • (2001) Int J Mol Med , vol.7 , pp. 455-478
    • Martin, L.J.1
  • 10
    • 0027501851 scopus 로고
    • Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
    • Linnik MD, Zobrist RH, Hatfield MD. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 1993;24:2002-9.
    • (1993) Stroke , vol.24 , pp. 2002-2009
    • Linnik, M.D.1    Zobrist, R.H.2    Hatfield, M.D.3
  • 11
    • 0031783714 scopus 로고    scopus 로고
    • Apoptosis after traumatic human spinal cord injury
    • Emery E, Aldana P, Bunge MB, et al. Apoptosis after traumatic human spinal cord injury. J Neurosurg 1998;89:911-20.
    • (1998) J Neurosurg , vol.89 , pp. 911-920
    • Emery, E.1    Aldana, P.2    Bunge, M.B.3
  • 12
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-57.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 13
    • 0033600301 scopus 로고    scopus 로고
    • Molecular basis of the neurodegenerative disorders
    • Erratum, N Engl J Med 1999; 341:1407
    • Martin JB. Molecular basis of the neurodegenerative disorders. N Engl J Med 1999; 340:1970-80. [Erratum, N Engl J Med 1999; 341:1407.]
    • (1999) N Engl J Med , vol.340 , pp. 1970-1980
    • Martin, J.B.1
  • 15
    • 0028894725 scopus 로고
    • In situ detection of DNA fragmentation after focal cerebral ischemia in mice
    • Li Y, Chopp M, Jiang N, Zaloga C. In situ detection of DNA fragmentation after focal cerebral ischemia in mice. Brain Res Mol Brain Res 1995;28:164-8.
    • (1995) Brain Res Mol Brain Res , vol.28 , pp. 164-168
    • Li, Y.1    Chopp, M.2    Jiang, N.3    Zaloga, C.4
  • 16
    • 0027714833 scopus 로고
    • Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain
    • MacManus JP, Buchan AM, Hill IE, Rasquinha I, Preston E. Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain. Neurosci Lett 1993; 164:89-92.
    • (1993) Neurosci Lett , vol.164 , pp. 89-92
    • MacManus, J.P.1    Buchan, A.M.2    Hill, I.E.3    Rasquinha, I.4    Preston, E.5
  • 17
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • Erratum, Nat Med 1997;3:240
    • Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3:73-6. [Erratum, Nat Med 1997;3:240.]
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3    Masters, J.N.4    Beattie, M.S.5
  • 18
    • 0034638259 scopus 로고    scopus 로고
    • Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury
    • Li M, Ona VO, Chen M, et al. Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience 2000;99:333-42.
    • (2000) Neuroscience , vol.99 , pp. 333-342
    • Li, M.1    Ona, V.O.2    Chen, M.3
  • 19
    • 16944363478 scopus 로고    scopus 로고
    • Neuronal and glial apoptosis after traumatic spinal cord injury
    • Liu XZ, Xu XM, Hu R, et al. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci 1997;17:5395-406.
    • (1997) J Neurosci , vol.17 , pp. 5395-5406
    • Liu, X.Z.1    Xu, X.M.2    Hu, R.3
  • 22
    • 0029563461 scopus 로고
    • Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons: Bcl-2 expression is increased in unaffected post-central gyrus
    • Troost D, Aten J, Morsink F, deJong JM. Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons: Bcl-2 expression is increased in unaffected post-central gyrus. Neuropathol Appl Neurobiol 1995;21: 498-504.
    • (1995) Neuropathol Appl Neurobiol , vol.21 , pp. 498-504
    • Troost, D.1    Aten, J.2    Morsink, F.3    DeJong, J.M.4
  • 24
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284:555-6.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 25
    • 0030916417 scopus 로고    scopus 로고
    • DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
    • Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997;89: 175-84.
    • (1997) Cell , vol.89 , pp. 175-184
    • Liu, X.1    Zou, H.2    Slaughter, C.3    Wang, X.4
  • 26
    • 0033119367 scopus 로고    scopus 로고
    • Genetic control of programmed cell death in the nematode Caenorhabditis elegans
    • Horvitz HR. Genetic control of programmed cell death in the nematode Caenorhabditis elegans. Cancer Res 1999;59: Suppl:1701s-1706s.
    • (1999) Cancer Res , vol.59 , Issue.SUPPL.
    • Horvitz, H.R.1
  • 27
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    • Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 1993;75:641-52.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 28
    • 0025255636 scopus 로고
    • The Caenorditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death
    • Yuan JY, Horvitz HR. The Caenorditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death. Dev Biol 1990;138:33-41.
    • (1990) Dev Biol , vol.138 , pp. 33-41
    • Yuan, J.Y.1    Horvitz, H.R.2
  • 29
    • 0027449187 scopus 로고
    • Induction ofapoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3
    • Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. Induction ofapoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993;75:653-60.
    • (1993) Cell , vol.75 , pp. 653-660
    • Miura, M.1    Zhu, H.2    Rotello, R.3    Hartwieg, E.A.4    Yuan, J.5
  • 30
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91: 479-89.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 31
    • 0028288277 scopus 로고
    • C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
    • Hengartner MO, Horvitz HR, C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994;76:665-76.
    • (1994) Cell , vol.76 , pp. 665-676
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 32
    • 0032524885 scopus 로고    scopus 로고
    • The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    • Conradt B, Horvitz HR, The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 1998;93:519-29.
    • (1998) Cell , vol.93 , pp. 519-529
    • Conradt, B.1    Horvitz, H.R.2
  • 34
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms ofcaspase activation and inhibition during apoptosis
    • Shi Y. Mechanisms ofcaspase activation and inhibition during apoptosis. Mol Cell 2002;9:459-70.
    • (2002) Mol Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 35
    • 0033912716 scopus 로고    scopus 로고
    • Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
    • Chen M, Ona VO, Li M, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000;6:797-801.
    • (2000) Nat Med , vol.6 , pp. 797-801
    • Chen, M.1    Ona, V.O.2    Li, M.3
  • 36
    • 0032708427 scopus 로고    scopus 로고
    • Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade
    • Fink KB, Andrews LJ, Butler WE, et al. Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade. Neuroscience 1999; 94:1213-8.
    • (1999) Neuroscience , vol.94 , pp. 1213-1218
    • Fink, K.B.1    Andrews, L.J.2    Butler, W.E.3
  • 37
    • 0031730617 scopus 로고    scopus 로고
    • ICE, neuronal apoptosis and neurodegeneration
    • Friedlander RM, Yuan J. ICE, neuronal apoptosis and neurodegeneration. Cell Death Differ 1998;5:823-31.
    • (1998) Cell Death Differ , vol.5 , pp. 823-831
    • Friedlander, R.M.1    Yuan, J.2
  • 38
    • 0034647003 scopus 로고    scopus 로고
    • Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
    • Li M, Ona VO, Guegan C, et al. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 2000; 288:335-9.
    • (2000) Science , vol.288 , pp. 335-339
    • Li, M.1    Ona, V.O.2    Guegan, C.3
  • 39
    • 0033587128 scopus 로고    scopus 로고
    • Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
    • Ona VO, Li M, Vonsattel JP, et al. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 1999;399:263-7.
    • (1999) Nature , vol.399 , pp. 263-267
    • Ona, V.O.1    Li, M.2    Vonsattel, J.P.3
  • 40
    • 0034610328 scopus 로고    scopus 로고
    • Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
    • Pasinelli P, Houseweart MK, Brown RH Jr, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2000;97:13901-6.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13901-13906
    • Pasinelli, P.1    Houseweart, M.K.2    Brown R.H., Jr.3    Cleveland, D.W.4
  • 41
    • 0034660250 scopus 로고    scopus 로고
    • Inhibition of caspase-1-like activity by Ac-TyrVal-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines
    • Rabuffetti M, Sciorati C, Tarozzo G, Clementi E, Manfredi AA, Beltramo M. Inhibition of caspase-1-like activity by Ac-TyrVal-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J Neurosci 2000;20:4398-404.
    • (2000) J Neurosci , vol.20 , pp. 4398-4404
    • Rabuffetti, M.1    Sciorati, C.2    Tarozzo, G.3    Clementi, E.4    Manfredi, A.A.5    Beltramo, M.6
  • 42
    • 0036703771 scopus 로고    scopus 로고
    • Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS
    • Sun W, Funakoshi H, Nakamura T. Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci 2002;22: 6537-48.
    • (2002) J Neurosci , vol.22 , pp. 6537-6548
    • Sun, W.1    Funakoshi, H.2    Nakamura, T.3
  • 43
    • 0034671376 scopus 로고    scopus 로고
    • Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis
    • Vukosavic S, Stefanis L, Jackson-Lewis V, et al. Delaying caspase activation by Bcl-2: a clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 2000;20:9119-25.
    • (2000) J Neurosci , vol.20 , pp. 9119-9125
    • Vukosavic, S.1    Stefanis, L.2    Jackson-Lewis, V.3
  • 44
    • 8044252166 scopus 로고    scopus 로고
    • Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury
    • Friedlander RM, Gagliardini V, Hara H, et al. Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med 1997;185:933-40.
    • (1997) J Exp Med , vol.185 , pp. 933-940
    • Friedlander, R.M.1    Gagliardini, V.2    Hara, H.3
  • 45
    • 0029978182 scopus 로고    scopus 로고
    • Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
    • Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996;380:723-6.
    • (1996) Nature , vol.380 , pp. 723-726
    • Enari, M.1    Talanian, R.V.2    Wong, W.W.3    Nagata, S.4
  • 46
    • 0036023965 scopus 로고    scopus 로고
    • CARD games in apoptosis and immunity
    • Bouchier-Hayes L, Martin SJ. CARD games in apoptosis and immunity. EMBO Rep 2002;3:616-21.
    • (2002) EMBO Rep , vol.3 , pp. 616-621
    • Bouchier-Hayes, L.1    Martin, S.J.2
  • 47
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998;391:96-9.
    • (1998) Nature , vol.391 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 48
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    • Erratum, Nature 1998;393:396
    • Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998;391: 43-50. [Erratum, Nature 1998;393:396.]
    • (1998) Nature , vol.391 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 49
    • 0032555215 scopus 로고    scopus 로고
    • The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
    • Liu X, Li P, Widlak P, et al. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A 1998;95:8461-6.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8461-8466
    • Liu, X.1    Li, P.2    Widlak, P.3
  • 50
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan PH, Koistinaho J. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A 1999;96:13496-500.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 52
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86:147-57.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 53
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001;15: 2922-33.
    • (2001) Genes Dev , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 54
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999;13:1899-911.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 55
    • 0035026438 scopus 로고    scopus 로고
    • Antiapoptotic proteins: The bcl-2 and inhibitor of apoptosis protein families
    • Deveraux QL, Schendel SL, Reed JC. Antiapoptotic proteins: the bcl-2 and inhibitor of apoptosis protein families. Cardiol Clin 2001;19:57-74.
    • (2001) Cardiol Clin , vol.19 , pp. 57-74
    • Deveraux, Q.L.1    Schendel, S.L.2    Reed, J.C.3
  • 56
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway ofapoptosis
    • Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway ofapoptosis. Cell 1998;94:491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 57
    • 0033564780 scopus 로고    scopus 로고
    • Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus
    • Xu D, Bureau Y, McIntyre DC, et al. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. J Neurosci 1999;19:5026-33.
    • (1999) J Neurosci , vol.19 , pp. 5026-5033
    • Xu, D.1    Bureau, Y.2    McIntyre, D.C.3
  • 59
    • 0030804272 scopus 로고    scopus 로고
    • Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
    • Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci 1997; 17:7415-24.
    • (1997) J Neurosci , vol.17 , pp. 7415-7424
    • Yakovlev, A.G.1    Knoblach, S.M.2    Fan, L.3    Fox, G.B.4    Goodnight, R.5    Faden, A.I.6
  • 60
    • 0032790541 scopus 로고    scopus 로고
    • Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
    • Springer JE, Azbill RD, Knapp PE. Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury. Nat Med 1999; 5:943-6.
    • (1999) Nat Med , vol.5 , pp. 943-946
    • Springer, J.E.1    Azbill, R.D.2    Knapp, P.E.3
  • 62
    • 0033617402 scopus 로고    scopus 로고
    • Involvement ofcaspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
    • Gervais FG, Xu D, Robertson GS, et al. Involvement ofcaspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 1999;97:395-406.
    • (1999) Cell , vol.97 , pp. 395-406
    • Gervais, F.G.1    Xu, D.2    Robertson, G.S.3
  • 63
    • 0029773397 scopus 로고    scopus 로고
    • An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat
    • Erratum, Neuroreport 1999;10(9):inside back cover
    • Loddick SA, MacKenzie A, Rothwell NJ. An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. Neuroreport 1996;7:1465-8. [Erratum, Neuroreport 1999;10(9):inside back cover.]
    • (1996) Neuroreport , vol.7 , pp. 1465-1468
    • Loddick, S.A.1    MacKenzie, A.2    Rothwell, N.J.3
  • 64
    • 0030614952 scopus 로고    scopus 로고
    • Inhibition of interlenkin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage
    • Hara H, Friedlander RM, Gagliardini V, et al. Inhibition of interlenkin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci U S A 1997;94:2007-12.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2007-2012
    • Hara, H.1    Friedlander, R.M.2    Gagliardini, V.3
  • 65
    • 0034192466 scopus 로고    scopus 로고
    • Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions
    • Kang SJ, Wang S, Hara H, et al. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol 2000;149:613-22.
    • (2000) J Cell Biol , vol.149 , pp. 613-622
    • Kang, S.J.1    Wang, S.2    Hara, H.3
  • 66
    • 0035884805 scopus 로고    scopus 로고
    • Specific caspase pathways are activated in the two stages of cerebral infarction
    • Benchoua A, Guegan C, Couriaud C, et al. Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci 2001;21:7127-34.
    • (2001) J Neurosci , vol.21 , pp. 7127-7134
    • Benchoua, A.1    Guegan, C.2    Couriaud, C.3
  • 67
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression ofamyotrophic lateral sclerosis in mice
    • Zhu S, Stavrovskaya IG, Drozda M, et al. Minocycline inhibits cytochrome c release and delays progression ofamyotrophic lateral sclerosis in mice. Nature 2002;417:74-8.
    • (2002) Nature , vol.417 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3
  • 68
    • 0027944004 scopus 로고
    • Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia
    • Martinou JC, Dubois-Dauphin M, Staple JK, et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 1994;13:1017-30.
    • (1994) Neuron , vol.13 , pp. 1017-1030
    • Martinou, J.C.1    Dubois-Dauphin, M.2    Staple, J.K.3
  • 69
    • 0035910099 scopus 로고    scopus 로고
    • BID mediates neuronal cell death after oxygenglucose deprivation and focal cerebral ischemia
    • Plesnila N, Zinkel S, Le DA, et al. BID mediates neuronal cell death after oxygenglucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A 2001;98: 15318-23.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15318-15323
    • Plesnila, N.1    Zinkel, S.2    Le, D.A.3
  • 70
    • 0031894316 scopus 로고    scopus 로고
    • Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice
    • Schielke GP, Yang GY, Shivers BD, Betz AL. Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice. J Cereb Blood Flow Metab 1998;18: 180-5.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 180-185
    • Schielke, G.P.1    Yang, G.Y.2    Shivers, B.D.3    Betz, A.L.4
  • 71
    • 0031718374 scopus 로고    scopus 로고
    • Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation
    • Fink K, Zhu J, Namura S, et al. Prolonged therapeutic window for ischemic brain damage caused by delayed caspase activation. J Cereb Blood Flow Metab 1998;18:1071-6.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 1071-1076
    • Fink, K.1    Zhu, J.2    Namura, S.3
  • 72
    • 0037095687 scopus 로고    scopus 로고
    • Caspase cascades in human immunodeficiency virus-associated neurodegeneration
    • Garden GA, Budd SL, Tsai E, et al. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci 2002;22:4015-24.
    • (2002) J Neurosci , vol.22 , pp. 4015-4024
    • Garden, G.A.1    Budd, S.L.2    Tsai, E.3
  • 73
    • 0033601995 scopus 로고    scopus 로고
    • Transgenic mice expressing a dominant negative mutant interleukin-1 beta converting enzyme show resistance to MPTP neurotoxicity
    • Klivenyi P, Andreassen O, Ferrante RJ, Schleicher JR Jr, Friedlander RM, Beal MF. Transgenic mice expressing a dominant negative mutant interleukin-1 beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport 1999;10:635-8.
    • (1999) Neuroreport , vol.10 , pp. 635-638
    • Klivenyi, P.1    Andreassen, O.2    Ferrante, R.J.3    Schleicher J.R., Jr.4    Friedlander, R.M.5    Beal, M.F.6
  • 74
    • 0035978743 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Rowland LP, Shneider NA. Amyotrophic lateral sclerosis. N Engl J Med 2001;344: 1688-700.
    • (2001) N Engl J Med , vol.344 , pp. 1688-1700
    • Rowland, L.P.1    Shneider, N.A.2
  • 75
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Erratum, Nature 1993;364:362
    • Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362: 59-62. [Erratum, Nature 1993;364:362.]
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3
  • 76
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
    • Erratum, Science 1995;269:149
    • Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science 1994;264:1772-5. [Erratum, Science 1995;269:149.]
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3
  • 77
    • 0033051815 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
    • Klivenyi P, Ferrante RJ, Matthews RT, et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med 1999;5:347-50.
    • (1999) Nat Med , vol.5 , pp. 347-350
    • Klivenyi, P.1    Ferrante, R.J.2    Matthews, R.T.3
  • 78
    • 0032896327 scopus 로고    scopus 로고
    • Neuronal death in amyotrophic lateral sclerosis is apoptosis: Possible contribution of a programmed cell death mechanism
    • Martin LJ. Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism. J Neuropathol Exp Neurol 1999; 58:459-71.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 459-471
    • Martin, L.J.1
  • 79
    • 0035437866 scopus 로고    scopus 로고
    • Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis
    • Guegan C, Vila M, Rosoklija G, Hays AP, Przedborski S. Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis. J Neurosci 2001;21:6569-76.
    • (2001) J Neurosci , vol.21 , pp. 6569-6576
    • Guegan, C.1    Vila, M.2    Rosoklija, G.3    Hays, A.P.4    Przedborski, S.5
  • 80
    • 0030756459 scopus 로고    scopus 로고
    • Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • Kostic V, Jackson-Lewis V, de Bilbao F, Dubois-Dauphin M, Przedborski S. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 1997;277:559-62.
    • (1997) Science , vol.277 , pp. 559-562
    • Kostic, V.1    Jackson-Lewis, V.2    De Bilbao, F.3    Dubois-Dauphin, M.4    Przedborski, S.5
  • 82
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-83.
    • (1993) Cell , vol.72 , pp. 971-983
  • 83
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini L, Sathasivam K, Seller M, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996;87:493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1    Sathasivam, K.2    Seller, M.3
  • 84
    • 17344367977 scopus 로고    scopus 로고
    • Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA
    • Reddy PH, Williams M, Charles V, et al. Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA. Nat Genet 1998;20:198-202.
    • (1998) Nat Genet , vol.20 , pp. 198-202
    • Reddy, P.H.1    Williams, M.2    Charles, V.3
  • 85
    • 0034660457 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease
    • Ferrante RJ, Andreassen OA, Jenkins BG, et al. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 2000;20:4389-97.
    • (2000) J Neurosci , vol.20 , pp. 4389-4397
    • Ferrante, R.J.1    Andreassen, O.A.2    Jenkins, B.G.3
  • 86
    • 0034703874 scopus 로고    scopus 로고
    • Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis
    • Li SH, Lam S, Cheng AL, Li XJ. Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis. Hum Mol Genet 2000;9:2859-67.
    • (2000) Hum Mol Genet , vol.9 , pp. 2859-2867
    • Li, S.H.1    Lam, S.2    Cheng, A.L.3    Li, X.J.4
  • 87
    • 0036048873 scopus 로고    scopus 로고
    • Cytochrome c and caspase-9 expression in Huntington's disease
    • Kiechle T, Dedeoglu A, Kubilus J, et al. Cytochrome c and caspase-9 expression in Huntington's disease. Neuromolecular Med 2002;1:183-95.
    • (2002) Neuromolecular Med , vol.1 , pp. 183-195
    • Kiechle, T.1    Dedeoglu, A.2    Kubilus, J.3
  • 88
    • 0033103523 scopus 로고    scopus 로고
    • Caspase-8 is required for cell death induced by expanded polyglutamine repeats
    • Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron 1999;22:623-33.
    • (1999) Neuron , vol.22 , pp. 623-633
    • Sanchez, I.1    Xu, C.J.2    Juo, P.3    Kakizaka, A.4    Blenis, J.5    Yuan, J.6
  • 89
    • 0035919701 scopus 로고    scopus 로고
    • Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    • Zuccato C, Ciammola A, Rigamonti D, et al. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 2001;293:493-8.
    • (2001) Science , vol.293 , pp. 493-498
    • Zuccato, C.1    Ciammola, A.2    Rigamonti, D.3
  • 90
    • 0034657112 scopus 로고    scopus 로고
    • Wild-type huntingtin protects from apoptosis upstream of caspase-3
    • Rigamonti D, Bauer JH, De-Fraja C, et al. Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci 2000;20:3705-13
    • (2000) J Neurosci , vol.20 , pp. 3705-3713
    • Rigamonti, D.1    Bauer, J.H.2    De-Fraja, C.3
  • 91
    • 0035805504 scopus 로고    scopus 로고
    • Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing
    • Rigamonti D, Sipione S, Goffredo D, Zuccato C, Fossale E, Cattaneo E. Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing. J Biol Chem 2001;276:14545-8.
    • (2001) J Biol Chem , vol.276 , pp. 14545-14548
    • Rigamonti, D.1    Sipione, S.2    Goffredo, D.3    Zuccato, C.4    Fossale, E.5    Cattaneo, E.6
  • 92
    • 9344227302 scopus 로고    scopus 로고
    • Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
    • Goldberg YP, Nicholson DW, Rasper DM, et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat Genet 1996;13:442-9.
    • (1996) Nat Genet , vol.13 , pp. 442-449
    • Goldberg, Y.P.1    Nicholson, D.W.2    Rasper, D.M.3
  • 93
    • 0032502715 scopus 로고    scopus 로고
    • Caspase cleavage ofgene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
    • Wellington CL, Ellerby LM, Hackam AS, et al. Caspase cleavage ofgene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J Biol Chem 1998;273: 9158-67.
    • (1998) J Biol Chem , vol.273 , pp. 9158-9167
    • Wellington, C.L.1    Ellerby, L.M.2    Hackam, A.S.3
  • 94
    • 0035937523 scopus 로고    scopus 로고
    • Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
    • Nucifora FC Jr, Sasald M, Peters MF, et al. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 2001;291:2423-8.
    • (2001) Science , vol.291 , pp. 2423-2428
    • Nucifora F.C., Jr.1    Sasald, M.2    Peters, M.F.3
  • 95
    • 0032568517 scopus 로고    scopus 로고
    • Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
    • Cha JH, Kosinski CM, Kerner JA, et al. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc Natl Acad Sci U S A 1998;95:6480-5.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6480-6485
    • Cha, J.H.1    Kosinski, C.M.2    Kerner, J.A.3
  • 96
    • 0035876916 scopus 로고    scopus 로고
    • Minocycline provides neuroprotection against N-methylD-aspartate neurotoxicity by inhibiting microglia
    • Tikka TM, Koistinaho JE. Minocycline provides neuroprotection against N-methylD-aspartate neurotoxicity by inhibiting microglia. J Immunol 2001;166:7527-33.
    • (2001) J Immunol , vol.166 , pp. 7527-7533
    • Tikka, T.M.1    Koistinaho, J.E.2
  • 97
    • 0034998271 scopus 로고    scopus 로고
    • Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
    • Sanchez Mejia RO, Ona VO, Li M, Friedlander RM. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction. Neurosurgery 2001;48:1393-401.
    • (2001) Neurosurgery , vol.48 , pp. 1393-1401
    • Sanchez Mejia, R.O.1    Ona, V.O.2    Li, M.3    Friedlander, R.M.4
  • 98
    • 0030695396 scopus 로고    scopus 로고
    • Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats
    • Shuman SL, Bresnahan JC, Beattie MS. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J Neurosci Res 1997;50:798-808.
    • (1997) J Neurosci Res , vol.50 , pp. 798-808
    • Shuman, S.L.1    Bresnahan, J.C.2    Beattie, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.