Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM

Diabetes

Volumn 45, Issue 6, 1996, Pages 749-754

  Rabinovitch, Alex ^a   Suarez Pinzon, Wilma ^a   El Sheikh, Amr ^a   Sorensen, Ole ^a   Power, Robert F ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HELPER CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MONOCYTE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0029922661     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.45.6.749     Document Type: Article

References (31)

1. Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev 15:516-542, 1994
2. Mandrup-Poulsen T, Helqvist S, Wogensen LD, Møvig J, Pociot F, Johannesen J, Nerup J: Cytokines and free radicals as effector molecules in the destruction of pancreatic β-cells. Curr Top Microbiol Immunol 164:169-193, 1990
3. Rabinovitch A: Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Metab Rev 1:215-240, 1993
4. Sadelain MWJ, Qin H-Y, Sumoski W, Parfrey N, Singh B, Rabinovitch A: Prevention of diabetes in the BB rat by early immunotherapy using Freund's adjuvant. J Autoimmun 3:671-680, 1990
5. Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco AP: Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 43:725-730, 1987
6. Jarpe AJ, Hickman MR, Anderson JT, Winter WE, Peck AB: Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes. Reg Immunol 3:305-317, 1991
7. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter KT: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299, 1979
8. Edgington ES: Randomization Tests. 2nd ed. New York, Marcel Dekker, 1987
9. Farrar MA, Schreiber RD: The molecular cell biology of interferon-γ and its receptor. Annu Rev Immunol 11:571-612, 1993
10. Seder RA, Paul WE: Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 12:635-673, 1994
11. Pukel C, Baquerizo H, Rabinovitch A: Destruction of rat islet cell monolayers by cytokines: synergistic interactions of interferon-γ, tumor necrosis factor, lymphotoxin, and interleukin 1. Diabetes 37:133-136, 1988
12. Campbell IL, Iscaro A, Harrison LC: IFN-γ and tumor necrosis factor-α: cytotoxicity to murine islets of Langerhans. J Immunol 141:2325-2329, 1988
13. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, Stewart TA: Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-γ. Cell 52:773-782, 1988
14. Campbell IL, Kay TWH, Oxbrow L, Harrison LC: Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest 87:739-742, 1991
15. Debray-Sachs M, Carnaud C, Boitard C, Cohen H, Gresser I, Bedossa P, Bach J-F: Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ. J Autoimmun 4:237-248, 1991
16. Nicoletti F, Meroni PL, Landolfo S, Gariglio M, Guzzardi S, Barcellini W, Lunetta M, Mughini L, Zanussi C: Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-γ (Abstract). Lancet 336:319, 1990
17. Anderson JT, Cornelius JG, Jarpe AJ, Winter WE, Peck AB: Insulin-dependent diabetes in the NOD mouse model II: β-cell destruction in autoimmune diabetes is a Th2- and not a Th1-mediated event. Autoimmunity 15:113-122, 1993
18. Rothe H, Faust A, Schade U, Kleemann R, Bosse G, Hibino T, Martin S, Kolb H: Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-γ, but not of interleukin-4. Diabetologia 37:1154-1158, 1994
19. Jiang Z, Edelmann L, Woda BA: Analysis of cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat utilizing the polymerase chain reaction (Abstract). Diabetes 41 (Suppl. 1):37A, 1992
20. Foulis AK, McGill M, Farquharson MA: Insulitis in type 1 (insulin-dependent) diabetes mellitus in man: macrophages, lymphocytes, and interferon-containing cells. J Pathol 165:97-103, 1991
21. Shehadeh N, LaRosa F, Lafferty KJ: Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J Autoimmun 6:291-300, 1993
22. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF: IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J Immunol 154:4874-4882, 1995
23. Muir A, Peck A, Clare-Salzler M, Song Y-H, Cornelius J, Luchetta R, Krischer J, MacLaren N: Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription. J Clin Invest 95:628-634, 1995
24. Haskins K, McDuffie M: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science 249:1433-1436, 1990
25. Wegmann DR, Gill RG, Norbury-Glaser M, Schloot N, Daniel D: Analysis of the spontaneous T cell response to insulin in NOD mice. J Autoimmun 7:833-843, 1994
26. Healey D, Ozegbe P, Arden S, Chandler P, Hutton J, Cooke A: In vivo activity and in vitro specificity of CD4+ Th1 and Th2 T cells derived from the spleens of diabetic NOD mice. J Clin Invest 95:2979-2985, 1995
27. Katz JD, Benoist C, Mathis D: T helper cell subsets in insulin-dependent diabetes. Science 268:1185-1188, 1995
28. Fitch FW, McKisic MD, Lancki DW, Gajewski TF: Differential regulation of murine T lymphocyte subsets. Annu Rev Immunol 11:29-48, 1993
29. Moore KV, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR: Interleukin 10. Annu Rev Immunol 11:165-190, 1993
30. Rossini AA, Greiner DL, Friedman HP, Mordes JP: Immunopathogenesis of diabetes mellitus. Diabetes Metab Rev 1:43-75, 1993
31. Rabinovitch A: Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes 43:613-621, 1994