Polymeric micelles for drug delivery

Expert Opinion on Drug Delivery

Volumn 3, Issue 1, 2006, Pages 139-162

  Aliabadi, Hamidreza Montazeri ^a   Lavasanifar, Afsaneh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Block copolymer; Drug delivery; Drug targeting; Polymeric micelles; Solubilisation

Indexed keywords

6 [4 DEOXY 4 (2,4 TETRADECADIENOYLGLYCYLAMINO) GLYCERO BETA MANNOHEPTOPYRANOSYLAMINO] 9H PURINE; AMIODARONE; AMPHOTERICIN B; ANDROSTANOLONE; CAMPTOTHECIN DERIVATIVE; CISPLATIN; CLONAZEPAM; COPOLYMER; CREMOPHOR; CYCLOSPORIN A; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; FENOFIBRATE; HALOPERIDOL; INDOMETACIN; MACROGOL; MENADIONE; METHOTREXATE; NIMODIPINE; NK 105; NK 911; PACLITAXEL; POLOXAMER; POLYAMINOACID; POLYASPARTIC ACID; POLYCAPROLACTONE; POLYESTER; POLYGLACTIN; POLYMER; POLYPROPYLENE; SP 1049C; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; CLINICAL TRIAL; CONTROLLED DRUG RELEASE; DIALYSIS; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DOSE REGIMEN; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG SOLUBILITY; DRUG TARGETING; EMULSION; ENCAPSULATION; EVAPORATION; FREEZE DRYING; GRAFT REJECTION; HUMAN; HYPERLIPIDEMIA; MICELLE; NEUROTOXICITY; NONHUMAN; PANCREAS CANCER; REVIEW; TUMOR;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HUMANS; MICELLES; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY;

EID: 30344488102     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.3.1.139     Document Type: Review

References (180)

1. ADAMS ML, LAVASANIFAR A, KWON GS: Amphiphilic block copolymers for drug delivery. J. Pharm. Sci. (2003) 92(7):1343-1355.
2. ALLEN C, EISENBERG A, MAYSINGER D: Copolymer drug carriers: conjugates, micelles and microspheres. S.T.P. Pharma Sciences (1999) 9(1):139-151.
3. ALLEN C, MAYSINGER D, EISENBERG A: Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf. B. Biointerfaces (1999) 16(1-4):3-27.
4. KABANOV AV, VINOGRADOV SV, SUZDALTSEVA YG, ALAKHOV V: Water-soluble block polycations as carriers for oligonucleotide delivery. Bioconjug. Chem. (1995) 6(6):639-643.
5. KAKIZAWA Y, KATAOKA K: Block copolymer micelles for delivery of gene and related compounds. Adv. Drug Deliv. Rev. (2002) 54(2):203-222.
6. KATAOKA K, HARADA A, NAGASAKI Y: Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. (2001) 47(1):113-131.
7. KATAOKA K, KWON GS, YOKOYAMA M, OKANO T, SAKURAI Y: Block copolymer micelles as vehicles for drug delivery. J. Control. Release (1993) 24(1-3):119-132.
8. KWON GS: Diblock copolymer nanoparticles for drug delivery. Crit. Rev. Ther. Drug Carrier Syst. (1998) 15(5):481-512.
9. KWON GS: Block copolymer micelles as drug delivery systems. Adv. Drug Deliv. Rev. (2002) 54(2):167.
10. KWON GS: Polymeric micelles for delivery of poorly water-soluble compounds. Crit. Rev. Ther. Drug Carrier Syst. (2003) 20(5):357-403.
11. KWON GS, OKANO T: Soluble self-assembled block copolymers for drug delivery. Pharm. Res. (1999) 16(5):597-600.
12. LAVASANIFAR A, SAMUEL J, KWON GS: Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery. Adv. Drug Deliv. Rev. (2002) 54(2):169-190.
13. TORCHILIN VP: PEG-based micelles as carriers of contrast agents for different imaging modalities. Adv. Drug Deliv. Rev. (2002) 54(2):235-252.
14. TORCHILIN VP: Targeted polymeric micelles for delivery of poorly soluble drugs. Cell. Mol. Life Sci. (2004) 61(19-20):2549-2559.
15. TORCHILIN VP, LUKYANOV AN, GAO Z, PAPAHADJOPOULOS-STERNBERG B: Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc. Natl Acad. Sci. USA (2003) 100(10):6039-6044.
16. TORCHILIN VP: Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release (2001) 73(2-3):137-172.
17. JONES M, LEROUX J: Polymeric micelles - a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm. (1999) 48(2):101-111.
18. LE GARREC D, RANGER M, LEROUX JC: Micelles in anticancer drug delivery. Am. J. Drug Delivery (2004) 2(1):15-42.
19. YOKOYAMA M, KWON GS, OKANO T et al.: In vivo antitumor activity of polymeric micelle anticancer drug against murine C 26 tumor. J. Control. Release (1994) 28(1-3):336-337.
20. KWON GS, YOKOYAMA M, OKANO T, SAKURAI Y, KATAOKA K: Enhanced tumor accumulation and prolonged circulation times of Micelle- forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J. Control. Release (1994) 28(1-3):334-335.
21. YOKOYAMA M, KWON GS, OKANO T et al.: Influencing factors on in vitro micelle stability of adriamycin-block copolymer conjugates. J. Control. Release (1994) 28(1-3):59-65.
22. KWON GS, YOKOYAMA M, OKANO T, SAKURAI Y, KATAOKA K: Biodistribution of micelle-forming polymer-drug conjugates. Pharm. Res. (1993) 10(7):970-974.
23. YOKOYAMA M, SUGIYAMA T, OKANO T et al.: Analysis of micelle formation of an adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer by gel permeation chromatography. Pharm. Res. (1993) 10(6):895-899.
24. YOKOYAMA M, INOUE S, KATAOKA K, YUI N, SAKURAI Y: Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer: a new type of polymeric anticancer agent. Makromol. Chem. (1987) 8:431-435.
25. YOKOYAMA M, MIYAUCHI M, YAMADA N et al.: Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. J. Control. Release (1990) 11(1-3):269-278.
26. YOKOYAMA M, MIYAUCHI M, YAMADA N et al.: Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer. Res. (1990) 50(6):1693-1700.
27. YOKOYAMA M, OKANO T, SAKURAI Y, KATAOKA K: Improved synthesis of adriamycin-conjugated poly(ethylene oxide)-poly(aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin. J. Control. Release (1994) 32:269-277.
28. YOO HS, LEE EA, PARK TG: Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages. J. Control. Release (2002) 82(1):17-27.
29. YOO HS, LEE KH, OH JE, PARK TG: In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. J. Control. Release (2000) 68(3):419-431.
30. YOO HS, PARK TG: Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J. Control. Release (2001) 70(1-2):63-70.
31. RAPOPORT NY, HERRON JN, PITT WG, PITINA L: Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. J. Control. Release (1999) 58(2):153-162.
32. KABANOV AV, CHEKHONIN VP, ALAKHOV V et al.: The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett. (1989) 258(2):343-345.
33. BATRAKOVA EV, LI S, MILLER DW, KABANOV AV: Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers. Pharm. Res. (1999) 16(9):1366-1372.
34. KWON GS, NAITO M, YOKOYAMA M et al.: Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. (1995) 12(2):192-195.
35. KIM SC, KIM DW, SHIM YH et al.: In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J. Control. Release (2001) 72(1-3):191-202.
36. YU BG, OKANO T, KATAOKA K, KWON G: Polymeric micelles for drug delivery: solubilization and haemolytic activity of amphotericin B. J. Control. Release (1998) 53(1-3):131-136.
37. LAVASANIFAR A, SAMUEL J, KWON GS: Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate L-aspartamide): synthetic analogues of lipoproteins for drug delivery. J. Biomed. Mater. Res. (2000) 52(4):831-835.
38. ALLEN C, EISENBERG A, MRSIC J, MAYSINGER D: PCL-b-PEO micelles as a delivery vehicle for FK506: Assessment of a functional recovery of crushed peripheral nerve. Drug Deliv. (2000) 7(3):139-145.
39. ALLEN C, HAN J, YU Y, MAYSINGER D, EISENBERG A: Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone. J. Control. Release (2000) 63(3):275-286.
40. LA SB, OKANO T, KATAOKA K: Preparation and characterization of the micelle-forming polymeric drug indomethacin-incorporated poly(ethylene oxide)-poly(beta-benzyl L-aspartate) block copolymer micelles. J. Pharm. Sci. (1996) 85(1):85-90.
41. KATAOKA K, MATSUMOTO T, YOKOYAMA M et al.: Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: Their pharmaceutical characteristics and biological significance. J. Control. Release (2000) 64(1-3):143-153.
42. KWON G, NAITO M, YOKOYAMA M et al.: Block copolymer micelles for drug delivery: loading and release of doxorubicin. J. Control. Release (1997) 48(2-3):195-201.
43. LAVASANIFAR A, SAMUEL J, KWON GS: The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-L-aspartamide). J. Control. Release (2002) 79(1-3):165-172.
44. ZHANG X, BURT HM, VON HOFF D et al.: An investigation of the antitumour activity and biodistribution of polymeric micellar paclitaxel. Cancer Chemother. Pharmacol. (1997) 40(1):81-86.
45. ZHANG X, JACKSON JK, BURT HM: Development of amphiphilic diblock copolymers as micellar carriers of taxol. Int. J. Pharm. (1996) 132(1-2):195-206.
46. SHUAI X, MERDAN T, SCHAPER AK, XI F, KISSEL T: Core-cross-linked polymeric micelles as paclitaxel carriers. Bioconjug. Chem. (2004) 15(3):441-448.
47. SHUAI X, AI H, NASONGKLA N, KIM S, GAO J: Micellar carriers based on block copolymers of poly(epsilon-caprolactone) and poly(ethylene glycol) for doxorubicin delivery. J. Control. Release (2004) 98(3):415-426.
48. LIU L, LI C, LI X et al.: Biodegradable polylactide/poly(ethylene glycol)/polylactide triblock copolymer micelles as anticancer drug carriers. J. Appl. Polym. Sci. (2001) 80:1976-1982.
49. JETTE KK, LAW D, SCHMITT EA, KWON GS: Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles through the evaporation of a cosolvent azeotrope. Pharm. Res. (2004) 21(7):1184-1191.
50. ALIABADI HM, MAHMUD A, DEHMOOBED SHARIFABADI A, LAVASANIFAR A: Micelles of methoxy poly(ethylene oxide)-b-poly(-caprolactone) as vehicles for the solublization and controlled delivery of cyclosporin A. J. Control. Release (2005) 104(2):301-311.
51. ALIABADI HM, BROCKS DR, LAVASANIFAR A: Polymeric micelles for the solublization and delivery of cyclosporine A: pharmacokinetics and biodistribution. Biomaterials (2005) 26(35):7251-7259.
52. LE GARREC D, GORI S, LUO L et al.: Poly(N-vinylpyrrolidone)-block-poly(D,L-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. J. Control. Release (2004) 99(1):83-101.
53. FOURNIER E, DUFRESNE MH, SMITH DC, RANGER M, LEROUX JC: A novel one-step drug-loading procedure for water-soluble amphiphilic nanocarriers. Pharm. Res. (2004) 21(6):962-968.
54. NISHIYAMA N, YOKOYAMA M, AOYAGA T et al.: Preparation and characterization of self-assembled polymer-metal complex micelle from cis-dichlorodiammineplatinium (II) and poly(ethylene glycole)-poly(aspartic acid) block copolymer in an aqueous medium. Langmuir (1999) 15:377-383.
55. NISHIYAMA N, OKAZAKI S, CABRAL H et al.: Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. Cancer Res. (2003) 63(24):8977-8983.
56. YUAN X, HARADA A, YAMASAKI Y, KATAOKA K: Stabilization of lysozyme-incorporated polyion complex micelles by the omega-end derivatization of poly(ethylene glycol)-poly(alpha,beta-aspartic acid) block copolymers with hydrophobic groups. Langmuir (2005) 21(7):2668-2674.
57. WAKEBAYASHI D, NISHIYAMA N, ITAKA K et al.: Polyion complex micelles of pDNA with acetal-poly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the gene carrier system: physicochemical properties of micelles relevant to gene transfection efficacy. Biomacromolecules (2004) 5(6):2128-2136.
58. WAKEBAYASHI D, NISHIYAMA N, YAMASAKI Y et al.: Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells. J. Control. Release (2004) 95(3):653-664.
59. ITAKA K, YAMAUCHI K, HARADA A et al.: Polyion complex micelles from pWmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency. Biomaterials (2003) 24(24):4495-4506.
60. GELDERBLOM H, VERWEIJ J, NOOTER K, SPARREBOOM A: Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur. J. Cancer (2001) 37:1590-1598.
61. THEIS JG, LIAU-CHU M, CHAN HS et al.: Anaphylactoid reactions in children receiving high-dose intravenous cyclosporine for reversal of tumor resistance: the causative role of improper dissolution of Cremophor EL. J. Clin. Oncol. (1995) 13(10):2508-2516.
62. THIEL G, HERMLE M, BRUNNER FP: Acutely impaired renal function during intravenous administration of cyclosporine A: a cremophore side-effect. Clin. Nephrol. (1986) 25(Suppl. 1):S40-S42.
63. TIBELL A, LARSSON M, ALVESTRAND A: Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat. Transpl. Int. (1993) 6(2):69-72.
64. CHEON LEE S, KIM C, CHAN KWON I, CHUNG H, YOUNG JEONG S: Polymeric micelles of poly(2-ethyl-2-oxazoline)-block-poly(epsilon-caprolactone) copolymer as a carrier for paclitaxel. J. Control. Release (2003) 89(3):437-446.
65. ELLIS AG, CRINIS NA, WEBSTER LK: Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80. Cancer Chemother. Pharmacol. (1996) 38(1):81-87.
66. ZHANG X, BURT HM, MANGOLD G et al.: Anti-tumor efficacy and biodistribution of intravenous polymeric micellar paclitaxel. Anticancer Drugs (1997) 8(7):696-701.
67. LEUNG SY, JACKSON J, MIYAKE H, BURT H, GLEAVE ME: Polymeric micellar paclitaxel phosphorylates Bcl-2 and induces apoptotic regression of androgen-independent LNCaP prostate tumors. Prostate (2000) 44(2):156-163.
68. PISKIN E, KAITIAN X, DENKBAS EB, KUCUKYAVUZ Z: Novel PDLLA/PEG copolymer micelles as drug carriers. J. Biomater. Sci. Polym. Ed. (1995) 7(4):359-373.
69. YOKOYAMA M, SATOH A, SAKURAI Y et al.: Incorporation of water-insoluble anticancer drug into polymeric micelles and control of their particle size. J. Control. Release (1998) 55(2-3):219-229.
70. MATSUMURA Y, YOKOYAMA M, KATAOKA K et al.: Reduction of the side effects of an antitumor agent, KRN5500, by incorporation of the drug into polymeric micelles. Jpn. J. Cancer Res. (1999) 90(1):122-128.
71. MIZUMURA Y, MATSUMURA Y, YOKOYAMA M et al.: Incorporation of the anticancer agent KRN5500 into polymeric micelles diminishes the pulmonary toxicity. Jpn. J. Cancer Res. (2002) 93(11):1237-1243.
72. LAVASANIFAR A, SAMUEL J, KWON GS: Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate L-aspartamide) by a solvent evaporation method: effect on the solubilization and haemolytic activity of amphotericin B. J. Control. Release (2001) 77(1-2):155-160.
73. LI Y, KWON GS: Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L-aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release. Pharm. Res. (2000) 17(5):607-611.
74. NISHIYAMA N, KOIZUMI F, OKAZAKI S et al.: Differential gene expression profile between PC-14 cells treated with free cisplatin and cisplatin-incorporated polymeric micelles. Bioconjug. Chem. (2003) 14(2):449-457.
75. MATSUYA T, TASHIRO S, HOSHINO N et al.: A core-shell-type fluorescent nanosphere possessing reactive poly(ethylene glycol) tethered chains on the surface for zeptomole detection of protein in time-resolved fluorometric immunoassay. Anal. Chem. (2003) 75(22):6124-6132.
76. LEE J, CHO EC, CHO K: Incorporation and release behavior of hydrophobic drug in functionalized poly(D,L lactide)-block-poly(ethylene oxide) micelles. J. Control. Release (2004) 94(2-3):323-335.
77. RAPOPORT N: Stabilization and activation of pluronic micelles for tumor-targeted drug delivery. Colloids Surf. B. Biointerfaces (1999) 16(1-4):93-111.
78. JEONG YI, NAH JW, LEE HC, KIM SH, CHO CS: Adriamycin release from flower-type polymeric micelle based on star-block copolymer composed of poly(gamma-benzyl L-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part. Int. J. Pharm. (1999) 188(1):49-58.
79. DUNCAN R: The dawning era of polymer therapeutics. Nature Rev. (2003) 2:347-360.
80. LI Y, KWON GS: Micelle-like structures of poly(ethylene oxide)-block-poly(2-hydroxyethyl aspartamide)-methotrexate conjugates. Colloids Surf. B. Biointerfaces (1999) 16:217-226.
81. YOKOYAMA M, OKANO T, SAKURAI Y et al.: Selective delivery of adiramycin to a solid tumor using a polymeric micelle carrier system. J. Drug Target. (1999) 7(3):171-186.
82. LAVASANIFAR A, SAMUEL J, SATTARI S, KWON GS: Block copolymer micelles for the encapsulation and delivery of amphotericin B. Pharm. Res. (2002) 19(4):418-422.
83. NAH JW, PAEK YW, JEONG YI et al.: Clonazepam release from poly(DL-lactide-co-glycolide) nanoparticles prepared by dialysis method. Arch. Pharm. Res (1998) 21(4):418-422.
84. JEONG YI, CHEON JB, KIM SH et al.: Clonazepam release from core-shell type nanoparticles in vitro. J. Control. Release (1998) 51(2-3):169-178.
85. TSUKIOKA Y, MATSUMURA Y, HAMAGUCHI T et al.: Pharmaceutical and biomedical differences between micellar doxorubicin (NK911) and liposomal doxorubicin (Doxil). Jpn. J. Cancer Res. (2002) 93(10):1145-1153.
86. LEE ES, NA K, BAE YH: Polymeric micelle for tumor pH and folate-mediated targeting. J. Control. Release (2003) 91(1-2):103-113.
87. BOGDANOV AA, JR., MARTIN C, BOGDANOVA AV, BRADY TJ, WEISSLEDER R: An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties. Bioconjug. Chem. (1996) 7(1):144-149.
88. CABRAL H, NISHIYAMA N, OKAZAKI S, KOYAMA H, KATAOKA K: Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles. J. Control. Release (2005) 101(1-3):223-232.
89. NISHIYAMA N, KATAOKA K: Preparation and characterization of size-controlled polymeric micelle containing cis-dichlorodiammineplatinum(II) in the core. J. Control. Release (2001) 74(1-3):83-94.
90. MATSUMURA Y, MAEDA H: A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. (1986) 46(12 Pt 1):6387-6392.
91. NAGASAKI Y, YASUGI K, YAMAMOTO Y, HARADA A, KATAOKA K: Sugar-installed block copolymer micelles: Their preparation and specific interaction with lectin molecules. Biomacromolecules (2001) 2(4):1067-1070.
92. YAMAMOTO Y, NAGASAKI Y, KATO M, KATAOKA K: Surface charge modulation of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles: conjugation of charged peptides. Colloids Surf. B. Biointerfaces (1999) 16(1-4):135-146.
93. RINGSDORF H, DORN K, HOERPEL G: Polymeric antitumor agents on molecular and cellular level. In: Bioactive Polymer Systems: an Overview. Gebelein CG Jr, Carraher CE (Eds), Plenum Press, New York, NY, USA (1985):531-585.
94. YOKOYAMA M, KWON GS, OKANO T et al.: Preparation of micelle forming polymer-drug conjugates. Bioconjug. Chem. (1992) 3:295-301.
95. YOKOYAMA M, OKANO T, SAKURAI Y et al.: Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res. (1991) 51(12):3229-3236.
96. KWON GS, SUWA S et al.: Enhanced tumor accumulation and prolonged circulation times for micelle-forming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J. Control. Release (1994) 29:17-23.
97. YOKOYAMA M, FUKUSHIMA S, UEHARA R et al.: Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor. J. Control. Release (1998) 50(1-3):79-92.
98. NAKANISHI T, FUKUSHIMA S, OKAMOTO K et al.: Development of the polymer micelle carrier system for doxorubicin. J. Control. Release (2001) 74(1-3):295-302.
99. MATSUMURA Y, HAMAGUCHI T, URA T et al.: Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br. J. Cancer (2004) 91(10):1775-1781.
100. MILLER DW, BATRAKOVA EV, WALTNER TO, ALAKHOV V, KABANOV AV: Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. Bioconjug. Chem. (1997) 8(5):649-657.
101. BATRAKOVA EV, MILLER DW, LI S et al.: Pluronic P85 enhances the delivery of digoxin to the brain: in vitro and in vivo studies. J. Pharmacol. Exp. Ther. (2001) 296(2):551-557.
102. ALAKHOV V, MOSKALEVA E, BATRAKOVA EV, KABANOV AV: Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer. Bioconjug. Chem. (1996) 7(2):209-216.
103. BATRAKOVA EV, DORODNYCH TY, KLINSKII EY et al.: Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity. Br. J. Cancer (1996) 74(10):1545-1552.
104. VENNE A, LI S, MANDEVILLE R, KABANOV A, ALAKHOV V: Hypersensitizing effect of pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells. Cancer Res. (1996) 56(16):3626-3629.
105. BATRAKOVA EV, HAN HY, ALAKHOV V, MILLER DW, KABANOV AV: Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers. Pharm. Res. (1998) 15(6):850-855.
106. BATRAKOVA EV, HAN HY, MILLER DW, KABANOV AV: Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells. Pharm. Res. (1998) 15(10):1525-1532.
107. MILLER DW, BATRAKOVA EV, KABANOV AV: Inhibition of multidrug resistance-associated protein (MRP) functional activity with pluronic block copolymers. Pharm. Res. (1999) 16(3):396-401.
108. BATRAKOVA E, LEE S, LI S et al.: Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells. Pharm. Res. (1999) 16(9):1373-1379.
109. ALAKHOV V, KLINSKI E, LI S et al.: Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloids Surf. B. Biointerfaces (1999) 16(1-4):113-134.
110. BATRAKOVA EV, LI S, ALAKHOV VY, MILLER DW, KABANOV AV: Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells. J. Pharmacol. Exp. Ther. (2003) 304(2):845-854.
111. KABANOV AV, BATRAKOVA EV, ALAKHOV VY: An essential relationship between ATP depletion and chemosensitizing activity of pluronic block copolymers. J. Control. Release (2003) 91(1-2):75-83.
112. DANSON S, FERRY D, ALAKHOV V et al.: Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer. Br. J. Cancer (2004) 90(11):2085-2091.
113. VALLE JW, LAWRANCE J, BREWER J et al.: A Phase II, window study of SP1049C as first-line therapy in inoperable metastatic adenocarcinoma of the esophagus. J. Clin. Oncol.. (2004) 22(14S):4195.
114. KIM TY, KIM DW, CHUNG JY et al.: Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies. Clin. Cancer Res. (2004) 10(11):3708-3716.
115. HAMAGUCHI T, MATSUMURA Y, SUZUKI M et al.: NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer (2005) 92(7):1240-1246.
116. NISHIYAMA N, KATO Y, SUGIYAMA Y, KATAOKA K: Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharm. Res. (2001) 18(7):1035-1041.
117. MIZUMURA Y, MATSUMURA Y, HAMAGUCHI T et al.: Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. Jpn. J. Cancer Res.. (2001) 92(3):328-336.
118. CURTIS JJ, LASKOW DA: Cyclosporine-induced nephrotoxicity: pathophysiology of decreased blood flow. Transplant. Proc. (1988) 20(3 Suppl. 3):540-543.
119. ANDOH TF, BENNETT WM: Chronic cyclosporine nephrotoxicity. Curr. Opin. Nephrol. Hypertens. (1998) 7(3):265-270.
120. LEE MK, CHOI L, KIM MH, KIM CK: Pharmacokinetics and organ distribution of cyclosporin A incorporated in liposomes and mixed micelles. Int. J. Pharm. (1999) 191(2):87-93.
121. FAHR A, HOLZ M, FRICKER G: Liposomal formulations of cyclosporin A: influence of lipid type and dose on pharmacokinetics. Pharm. Res. (1995) 12(8):1189-1198.
122. CHOICE E: Liposomal cyclosporine. Comparison of drug and lipid carrier pharmacokinetics and biodistribution. Transplantation (1995) 60(9):1006-1011.
123. KAKIZAWA Y, HARADA A, KATAOKA K: Glutathione-sensitive stabilization of block copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-block-poly(L-lysine): a potential carrier for systemic delivery of antisense DNA. Biomacromolecules (2001) 2(2):491-497.
124. GAO T, ULUDAG H: Effect of molecular weight of thermoreversible polymer on in vivo retention of rhBMP-2. J. Biomed. Mater. Res. (2001) 57(1):92-100.
125. KANG N, PERRON ME, PRUD'HOMME RE et al.: Stereocomplex block copolymer micelles: core-shell nanostructures with enhanced stability. Nano Letters (2005) 5(2):315-319.
126. ONYUKSEL H, IKEZAKI H, PATEL M, GAO XP, RUBINSTEIN I: A novel formulation of VIP in sterically stabilized micelles amplifies vasodilation in vivo. Pharm. Res. (1999) 16(1):155-160.
127. GANDHI S, TSUESHITA T, ONYUKSEL H, CHANDIWALA R, RUBINSTEIN I: Interactions of human secretin with sterically stabilized phospholipid micelles amplify peptide-induced vasodilation in vivo. Peptides (2002) 23(8):1433-1439.
128. RUBINSTEIN I, ASHOK B, TSUESHITA T, ONYUKSEL H: All D-VIP mitigates vasodilation elicited by L-VIP, micellar L-VIP and micellar PACAP1-38, but not PACAP1-38, in vivo. Peptides (2005) 26(3):509-515.
129. OISHI M, NAGATSUGI F, SASAKI S, NAGASAKI Y, KATAOKA K: Smart polyion complex micelles for targeted intracellular delivery of PEGylated antisense oligonucleotides containing acid-labile linkages. Chembiochem. (2005) 6(4):718-725.
130. DUFRESNE MH, GAUTHIER MA, LEROUX JC: Thiol-functionalized polymeric micelles: From molecular recognition to improved mucoadhesion. Bioconjug. Chem. (2005) 16(4):1027-1033.
131. VINOGRADOV S, BATRAKOVA E, LI S, KABANOV A: Polyion complex micelles with protein-modified corona for receptor-mediated delivery of oligonucleotides into cells. Bioconjug. Chem. (1999) 10(5):851-860.
132. OISHI M, NAGASAKI Y, ITAKA K, NISHIYAMA N, KATAOKA K: Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J. Am. Chem. Soc. (2005) 127(6):1624-1625.
133. JULE E, NAGASAKI Y, KATAOKA K: Lactose-installed poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles exhibit fast-rate binding and high affinity toward a protein bed simulating a cell surface. A surface plasmon resonance study. Bioconjug. Chem. (2003) 14(1):177-186.
134. FRANCIS MF, PIREDDA M, WINNIK FM: Solubilization of poorly water soluble drug in micelles of hydrophobically modified hydroxypropylcellulose copolymers. J. Control. Release (2003) 93(1):59-68.
135. FRANCIS MF, LAVOIE L, WINNIK FM, LEROUX JC: Solubilization of cyclosporin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles. Eur. J. Pharm. Biopharm. (2003) 56(3):337-346.
136. FRANCIS MF, CRISTEA M, YANG Y, WINNIK FM: Engineering polysaccharide-based polymeric micelles to enhance permeability of cyclosporin A across Caco-2 cells. Pharm. Res. (2005) 22(2):209-219.
137. KOHORI F, SAKAI K, AOYAGI T et al.: Control of adriamycin cytotoxic activity using thermally responsive polymeric micelles composed of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(-lactide). Colloids Surf. B. Biointerfaces (1999) 16(1-4):195-205.
138. KOHORI F, SAKAI K, AOYAGI T et al.: Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide). J. Control. Release (1998) 55(1):87-98.
139. KIM I-S, JEONG Y-I, CHO C-S, KIM SH: Thermo-responsive self-assembled polymeric micelles for drug delivery in vitro. Int. J. Pharm. (2000) 205(1-2):165-172.
140. SOGA O, VAN NOSTRUM CF, FENS M et al.: Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery. J. Control. Release (2005) 103(2):341-353.
141. CHUNG JE, YOKOYAMA M, YAMATO M et al.: Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate). J. Control. Release (1999) 62(1-2):115-127.
142. PITT WG, HUSSEINI GA, STAPLES B: Ultrasonic drug delivery - a general review. Expert Opin. Drug Deliv. (2004) 1(1):37-56.
143. RAPOPORT NY, CHRISTENSEN DA, FAIN HD, BARROWS L, GAO Z: Ultrasound-triggered drug targeting of tumors in vitro and in vivo. Ultrasonics (2004) 42(1-9):943-950.
144. RAPOPORT N, PITT WG, SUN H, NELSON JL: Drug delivery in polymeric micelles: from in vitro to in vivo. J. Control. Release (2003) 91(1-2):85-95.
145. RAPOPORT N, MARIN A, LUO Y, PRESTWICH GD, MUNIRUZZAMAN MD: Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. J. Pharm. Sci. (2002) 91(1):157-170.
146. RAPOPORT N: Combined cancer therapy by micellar-encapsulated drug and ultrasound. Int. J. Pharm. (2004) 277(1-2):155-162.
147. GAO Z-G, FAIN HD, RAPOPORT N: Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound. J. Control. Release (2005) 102(1):203-222.
148. GAO Z, FAIN HD, RAPOPORT N: Ultrasound-enhanced tumor targeting of polymeric micellar drug carriers. Mol. Pharm. (2004) 1(4):317-330.
149. MUNSHI N, RAPOPORT N, PITT WG: Ultrasonic activated drug delivery from pluronic P-105 micelles. Cancer Lett. (1997) 118(1):13-19.
150. HUSSEINI GA, EL-FAYOUMI RI, O'NEILL KL, RAPOPORT NY, PITT WG: DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study. Cancer Lett. (2000) 154(2):211-216.
151. HUSSEINI GA, CHRISTENSEN DA, RAPOPORT NY, PITT WG: Ultrasonic release of doxorubicin from pluronic P105 micelles stabilized with an interpenetrating network of N,N-diethylacrylamide. J. Control. Release (2002) 83(2):303-305.
152. LE GARREC D, TAILLEFER J, VAN LIER JE, LENAERTS V, LEROUX JC: Optimizing pH-responsive polymeric micelles for drug delivery in a cancer photodynamic therapy model. J. Drug Target. (2002) 10(5):429-437.
153. LEROUX JC, ROUX E, LE GARREC D, HONG K, DRUMMOND DC: N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. J. Control. Release (2001) 72(1-3):71-84.
154. TAILLEFER J, BRASSEUR N, VAN LIER JE et al.: In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model. J. Pharm. Pharmacol. (2001) 53(2):155-166.
155. TAILLEFER J, JONES MC, BRASSEUR N, VAN LIER JE, LEROUX JC: Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs. J. Pharm. Sci. (2000) 89(1):52-62.
156. OISHI M, SASAKI S, NAGASAKI Y, KATAOKA K: pH-responsive oligodeoxynucleotide (ODN)-poly(ethylene glycol) conjugate through acid-labile beta-thiopropionate linkage: preparation and polyion complex micelle formation. Biomacromolecules (2003) 4(5):1426-1432.
157. HRUBY M, KONAK C, ULBRICH K: Polymeric micellar pH-sensitive drug delivery system for doxorubicin. J. Control. Release (2005) 103(1):137-148.
158. LEE ES, NA K, BAE YH: Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor. J. Control. Release (2005) 103(2):405-418.
159. DUFRESNE MH, LE GARREC D, SANT V, LEROUX JC, RANGER M: Preparation and characterization of water-soluble pH-sensitive nanocarriers for drug delivery. Int. J. Pharm. (2004) 277(1-2):81-90.
160. SANT VP, SMITH D, LEROUX JC: Novel pH-sensitive supramolecular assemblies for oral delivery of poorly water soluble drugs: preparation and characterization. J. Control. Release (2004) 97(2):301-312.
161. SANT VP, SMITH D, LEROUX JC: Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies. J. Control. Release (2005) 104(2):289-300.
162. JONES MC, RANGER M, LEROUX JC: pH-sensitive unimolecular polymeric micelles: synthesis of a novel drug carrier. Bioconjug. Chem. (2003) 14(4):774-781.
163. YOO HS, PARK TG: Folate receptor targeted biodegradable polymeric doxorubicin micelles. J. Control. Release (2004) 96(2):273-283.
164. RAMASWAMY M, ZHANG X, BURT HM, WASAN KM: Human plasma distribution of free paclitaxel and paclitaxel associated with diblock copolymers. J. Pharm. Sci. (1997) 86(4):460-464.
165. ZHANG X, BURT HM, MANGOLD G et al.: Anti-tumor efficacy and biodistribution of intravenous polymeric micellar paclitaxel. Anticancer Drugs (1997) 8(7):696-701.
166. BURT HM, ZHANG X, TOLEIKIS P, EMBREE L, HUNTER WL: Developement of copolymers of poly(D,L-lactide) and methoxypropylene glycol as micellar carriers of paclitaxel. Colloids Surf. B. Biointerfaces (1999) 16:161-171.
167. GAO Z, LUKYANOV AN, SINGHAL A, TORCHILIN VP: Diacyl-polymer micelles as nanocarriers for poorly soluble anticancer drugs. Nano Letters (2002) 2:979-982.
168. YU BG, OKANO T, KATAOKA K, SARDARI S, KWON GS: In vitro dissociation of antifungal efficacy and toxicity for amphotericin B-loaded poly(ethylene oxide)-block-poly(beta benzyl L-aspartate) micelles. J. Control. Release (1998) 56(1-3):285-291.
169. ADAMS ML, KWON GS: Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles: effects of acyl chain length. J. Control. Release (2003) 87(1-3):23-32.
170. ADAMS ML, ANDES DR, KWON GS: Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules (2003) 4(3):750-757.
171. SHIN IG, KIM SY, LEE YM, CHO CS, SUNG YK: Methoxy poly(ethylene glycol)/epsilon-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. Preparation and characterization. J. Control. Release (1998) 51(1):1-11.
172. KIM SY, SHIN IG, LEE YM, CHO CS, SUNG YK: Methoxy poly(ethylene glycol) and epsilon-caprolactone amphiphilic block copolymeric micelle containing indomethacin. II. Micelle formation and drug release behaviours. J. Control. Release (1998) 51(1):13-22.
173. BENAHMED A, RANGER M, LEROUX JC: Novel polymeric micelles based on the amphiphilic diblock copolymer poly(N-vinyl-2-pyrrolidone)-block-poly(D,L-lactide). Pharm. Res. (2001) 18(3):323-328.
174. GE H, HU Y, JIANG X et al.: Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(epsilon-caprolactone)-poly(ethylene oxide)-poly(epsilon-caprolactone) amphiphilic triblock copolymer micelles. J. Pharm. Sci. (2002) 91(6):1463-1473.
175. RYU J, JEONG YI, KIM IS et al.: Clonazepam release from core-shell type nanoparticles of poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) triblock copolymers. Int. J. Pharm. (2000) 200(2):231-242.
176. CHI SC, YEOM DI, KIM SC, PARK ES: A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate. Arch. Pharm. Res. (2003) 26(2):173-181.
177. WANG J, MONGAYT DA, LUKYANOV AN, LEVCHENKO TS, TORCHILIN VP: Preparation and in vitro synergistic anticancer effect of vitamin K3 and 1,8-diazabicyclo[5,4,0]undec-7-ene in poly(ethylene glycol)-diacyllipid micelles. Int. J. Pharm. (2004) 272(1-2):129-135.
178. LE GARREC D, GORI S, KARKAN D et al.: Preparation, characterization, cytotoxicity and biodistribution of docetaxel-loaded polymeric micelle formulations. S.T.P. Pharma Sciences (2005) 15(2):115-120.
179. ALAKHOV V, KLINSKI E, LI S et al.: Block copolymer-based formulation of doxorubicin: From cell screen to clinical trials. Colloids Surf. B. Biointerfaces (1999) 16:113-134.
180. SHI B, FANG C, YOU M X, ZHANG Y, FU S, PEI Y Y: Stealth MePEG-PCL micelles: Effects of polymer composition on micelle physicochemical characteristics, in vitro drug release, in vivo pharmacokinetics in rats and biodistribution in S180 tumor bearing mice. Coll. Polym. Sci. (2005) 283(9): 954-967.