Effects of pluronic block copolymers on drug absorption in Caco-2 cell monolayers

Pharmaceutical Research

Volumn 15, Issue 6, 1998, Pages 850-855

  Batrakova, Elena V ^a   Han, Huai Yun ^a   Alakhov, Valery Yu ^b   Miller, Donald W ^a   Kabanov, Alexander V ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

Block copolymer; Drug; Intestinal delivery; Micelles

Indexed keywords

COPOLYMER; POLOXAMER;

ARTICLE; CELL STRAIN CACO 2; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; MICELLE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL;

CACO-2 CELLS; DETERGENTS; HUMANS; MICELLES; MICROSCOPY, FLUORESCENCE; PHARMACOKINETICS; POLOXALENE;

EID: 0031800878     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011964213024     Document Type: Article

References (21)

1. S. Y. Lin and Y. Kawashima. Pluronic surfactants affecting diazepam solubility, compatibility, and adsorbtion from i.v. admixture solutions. J. Parenter. Sci. Technol. 41:83-87 (1987).
2. A. V. Kabanov, V. P. Chekhonin, V. Yu. Alakhov, E. V. Batrakova, A. S. Lebedev, N. S. Melik-Nubarov, S. A. Arzhakov, A. V. Levashov, G. V. Morozov, E. S. Severin, and V. A. Kabanov. The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett 258:343-345 (1989).
3. A. Rolland, J. O'Mullane, P. Goddard, L. Brookman, and K. Petrak. New macromolecular carriers for drugs. 1. Preparation and characterization of poly(oxyethylene-b-isoprene-b-oxyethylene) block copolymer aggregates. J. Appl. Polym. Sci. 44:1195-1203 (1992).
4. G. S. Kwon, M. Naito, M. Yokoyama, T. Okano, Y. Sakurai, and K. Kataoka. Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. 12:192-195 (1995).
5. S. A. Hagan, A. G. A. Coombes, M. C. Garnett, S. E. Dunn, M. C. Davies, L. Illum, S. S. Davis, S. E. Harding, S. Purkiss, and P. R. Gellert. Polylactide-poly(ethylene glycol) copolymers as drug delivery systems. I. Characterization of water dispersible micelle-forming systems. Langmuir 12:2153-2161 (1996).
6. X. Zhang, J. K. Jackson, and H. M. Burt. Development of amphiphilic block copolymers as micellar carriers of taxol. Int. J. Pharm. 132:195-206 (1996).
7. A. V. Kabanov, E. V. Batrakova, N. S. Melik-Nubarov, N. A. Fedoseev, T. Yu. Dorodnich, V. Yu. Alakhov, V. P. Chekhonin, I. R. Nazarova, and V. A. Kabanov. A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain. J. Contr. Release 22:141-158 (1992).
8. D. W. Miller, E. V. Batrakova, T. O. Waltner, V. Yu. Alakhov, and A. V. Kabanov. Interactions of Pluronic block copolymers with brain microvessel endothelial cells: evidence for multiple absorption pathways. Bioconjugate Chem. 8:649-657 (1997).
9. K. I. Hosoya, K. J. Kim, and V. H. Lee. Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers. Pharm. Res. 13:885-890 (1996).
10. G. Wilson. Cell culture techniques for the study of drug transport. Eur. J. Drug Metab. Pharmacokinet. 15:159-163 (1990).
11. J. Fogh, J. M. Fogh, and T. J. Orfeo. One hundred and twenty seven cultured human cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59:221-226 (1977).
12. P. Artursson. Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J. Pharm. Sci. 79:476-482 (1990).
13. M. Fontaine, W. F. Elmquist, and D. W. Miller. Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. Life Sci. 59:1521-1531, 1996.
14. T. J. Lampidis, C. Castello, A. Del Giglio, B. C. Pressman, P. Viallet, K. W. Trevonrow, G. K. Valet, H. Tapiero, and N. Savaraj. Relevance of the chemical charge of rhodamine dyes to multiple drug resistance. Biochem. Pharmacol. 38:4267-4271 (1989).
15. A. V. Kabanov, I. R. Nazarova, I. V. Astafieva, E. V. Batrakova, V. Yu. Alakhov, A. A. Yaroslavov, and V. A. Kabanov. Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions. Macromolecules 28:2303-2314 (1995).
16. M. M. Nerurkar, P. S. Burton, and R. T. Borchardt. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm. Res. 13:528-534 (1996).
17. P. K. Dudeja, K. M. Anderson, J. S. Harris, L. Buckingham and J. S. Coon. Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity. Arch. Biochem. Biophys. 319:309-315 (1995).
18. V. Yu. Alakhov, E. Yu. Moskaleva, E. V. Batrakova and A. V. Kabanov. Hypersensitization of multidrug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer. Bioconjugate Chem. 7:209-216 (1996).
19. A. Venne, S. Li, R. Mandeville, A. V. Kabanov and V. Yu. Alakhov. Hypersensitizing effect of Pluronic L61 on cytotoxic activity, transport, and subcellular distribution of doxorubicin in multiple drug-resistant cells. Cancer Research 56:3626-3629 (1996).
20. M. M. Nerurkar, N. F. H. Ho, P. S. Burton, T. J. Vidmar and R. T. Borchardt. Mechanistic roles of neutral surfactants on concurrent polarized and passive membrane transport of a model peptide in Caco-2 cells. J. Pharm. Sci. 7:813-821 (1997).
21. P. Alexandridis, V. Athanassiou, S. Fukuda, and T. A. Hatton. Surface activity of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) copolymers. Langmuir 10:2604-2612 (1994).