Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies

Journal of Controlled Release

Volumn 104, Issue 2, 2005, Pages 289-300

  Sant, Vinayak P ^a   Smith, Damon ^b   Leroux, Jean Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b Labopharm Inc   (Canada)

Author keywords

Atom transfer radical polymerization; Drug solubilization; Fenofibrate; Oral bioavailability; pH sensitive; Polymeric micelles

Indexed keywords

BLOCK COPOLYMERS; CONTROLLED DRUG DELIVERY; EMULSIONS; HYDROPHOBICITY; MICELLES; PH; POLYETHYLENE GLYCOLS; SELF ASSEMBLY;

ATOM TRANSFER RADICAL POLYMERIZATION; BIOAVAILABILITY; DRUG RELEASE; POLYMERIC MICELLES;

DRUG PRODUCTS;

FENOFIBRATE; LIPIDIL MICRO; MACROGOL; POLY(ACRYLATE METHACRYLATE); POLYMER; PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; EMULSION; HYDROPHOBICITY; IN VITRO STUDY; IONIZATION; MICELLE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RAT STRAIN;

ACRYLATES; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HYDROGEN-ION CONCENTRATION; MALE; METHACRYLATES; MICELLES; POLYETHYLENE GLYCOLS; PROCETOFEN; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 19444375996     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.02.010     Document Type: Article

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