Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer

Bioconjugate Chemistry

Volumn 7, Issue 2, 1996, Pages 209-216

  Alakhov, Valery Yu ^a,b   Moskaleva, Elizaveta Yu ^a   Batrakova, Elena V ^a,c   Kabanov, Alexander V ^a,c  

^a Russ Res Ctr Molec D/T ^*  (Russian Federation)

^b INRS INSTITUT ARMAND FRAPPIER   (Canada)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOTOXICITY; DRUG DELIVERY;

BLOCK CO POLYMERS; CYTOTOXIC ACTIVITIES; DAUNORUBICIN; HYPERSENSITIZATION; MULTIDRUG RESISTANTS; OVARIAN CARCINOMA; OVARIAN CARCINOMA CELL; PLURONICS; RESISTANT CELLS; SENSITISATION;

BLOCK COPOLYMERS;

EID: 0030111359     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc950093n     Document Type: Article

References (9)

1. Goldstein, L. J., Gottesman, M. M., and Pastan, I. (1991) Expression of the MDR1 gene in human cancers. Cancer Treat. Res. 57, 101-119.
2. Goldstein, L. J., Gottesman, M. M., and Pastan, I. (1992) Multidrug resistance in human cancers. Crit. Rev. Oncol. Hematol. 12, 243-253.
3. Gros, P., Neriah, Y. B., Croop, J. M., and Housman, D. E. (1986) Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 32, 728-731.
4. Ueda, K., Cardarelli, C., Gottesman, M. M., and Pastan, I. (1987) Expression of a full-length cDNA for the human MDR1 gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl. Acad. Sci. U.S.A. 84, 3004-3008.
5. Higgins, C. F., and Gottesman, M. M. (1992) Is the multidrug transporter a flippase? TIBS 17, 18-21.
6. Chong, A. S., Markham, P. N., Gebel, H. M., Bines, S. D., and Coon, J. S. (1993) Diverse muludrug-resistance-modification agents inhibit cytolytic activity of natural killer cells. Cancer Immunol. Immunother. 36, 133-139.
7. Kabanov, A. V., Chekhonin, V. P., Alakhov, V. Yu., Batrakova, E. V., Lebedev, A. S., Melik-Nubarov, N. S., Arzhakov, S. A., Levashov, A. V., Morozov, G. V., Sevenn, E. S., and Kabanov, V. A. (1989) The neuroleptic activity of haloperidol increases after its solubuization in surfactant micelles. Micelles as microcontainers for drug targeting. FEBS Lett. 268, 343-345.
8. Kabanov, A. V., Batrakova, E. V., Melik-Nubarov, N. S., Fedoseev, N. A., Dorodnich, T. Yu., Alakhov, V. Yu., Chekhonin, V. P., Nazarova, I. S., and Kabanov, V. A. (1992) A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain. J. Controlled Release 22, 141-158.
9. Page, M., and Alakhov, V. Yu. (1992) Elimination of P-gp-mediated muludrug resistance by solubilization in Pluronic micelles (Meeting Abstract). Proc. Annu. Meet. Am. Assoc. Cancer Res. 33, A3302.