Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide)

Journal of Controlled Release

Volumn 55, Issue 1, 1998, Pages 87-98

  Kohori, Fukashi ^a   Sakai, Kiyotaka ^a   Aoyagi, Takao ^b   Yokoyama, Masayuki ^b   Sakurai, Yasuhisa ^b   Okano, Teruo ^b  

^a WASEDA UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Poly(DL lactide); Poly(N isopropylacrylamide); Polymeric micelles; Thermally sensitive

Indexed keywords

COPOLYMER; POLY(N ISOPROPYLACRYLAMIDE LACTIDE); UNCLASSIFIED DRUG;

ARTICLE; DIALYSIS; DRUG SYNTHESIS; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; MICELLE; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; POLYMERIZATION; PRIORITY JOURNAL; REACTION ANALYSIS; TEMPERATURE; TURBIDITY;

ACRYLAMIDES; CHROMATOGRAPHY, GEL; LIGHT; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MICROSCOPY, ATOMIC FORCE; SCATTERING, RADIATION; SPECTROMETRY, FLUORESCENCE; TEMPERATURE;

EID: 0031751919     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00023-6     Document Type: Article

References (28)

1. Couvreur P., Vauthier C. Polyalkylcyanoacrylate nanoparticles as drug carrier: Present state and perspective. J. Control. Rel. 17:1991;187-198.
2. Kreuter J. Nanoparticle-based drug delivery systems. J. Control. Rel. 16:1991;169-176.
3. J.N. Weinstein, Liposomes in the diagnosis and treatment of cancer, in: M.J. Ostro (Ed.), Liposomes: From Biophysics to Therapeutics, Marcel Dekker, New York, 1987, pp. 277-338.
4. Tardi P.G., Boman N.L., Cullis P.R. Review: Liposomal doxoruicin. J. Drug Targeting. 4:1986;129-140.
5. Putnam D., Kopecek J. Polymer conjugates with anticancer activity. Adv. Polym. Sci. 122:1995;55-123.
6. Duncan R., Dimitrijevic S., Evagorou E.G. The role of polymer conjugates in the diagnosis and treatment of cancer. S.T.P. Pharma Sci. 6:1996;237-263.
7. T. Okano (Ed.), Targetable drug carriers, Adv. Drug Delivery Rev. 21(2) (1996).
8. Yang H.M., Reisfeld R. Doxorubicin conjugated with a monoclonal antibody directed to a human melanoma-associated proteoglycan suppresses the growth of established tumor xenografts in nude mice. Proc. Natl. Acad. Sci. USA. 85:1988;1189-1193.
9. Thédrez P., Saccavini J.C., Nolibé D.et al. Biodistribution of indium-111-labeled OC 125 monoclonal antibody after intraperitoneal injection in nude mice intraperitoneally grafted with ovarian carcinoma. Cancer Res. 49:1989;3081-3086.
10. Yokoyama M. Block copolymers as drug carriers. Therapeut. Drug Carrier Sys. 9(3,4):1992;213-248.
11. Tuzar Z., Kratochvil P. Block and graft copolymer micelles in solution. Adv. Colloid Interface Sci. 6:1976;201-232.
12. Wilhelm M., Zhao C., Wang Y.et al. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: A fluorescence probe study. Macromolecules. 24:1991;1033-1040.
13. Yokoyama M., Miyauchi M., Yamada N.et al. Polymer micelles as novel drug carrier adriamycin-conjugated poly (ethyleneglycol)-poly (aspartic acid) block copolymer. J. Control. Rel. 11:1990;269-278.
14. Kwon G.S., Yokoyama M., Okano T.et al. Biodistribution of micelle-forming polymer-drug conjugates. Pharm. Res. 10:1993;970-974.
15. Cammas S., Suzuki K., Sone Y.et al. Thermoresponsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers. J. Control. Rel. 48:1997;157-164.
16. Chung J.E., Yokoyama M., Suzuki K.et al. Reversibly thermoresponsive alkyl-terminated poly (N-isopropylacriylamide) core-shell micellar structures. Colloids Surfaces B: Biointerfaces. 9:1997;37-48.
17. Heskins M., Guillet J.E. Solution properties of poly (N-isopropylacrylamide). J. Macromol. Sci. Chem. A2:1968;1441-1455.
18. Yamada N., Okano T., Sakai H.et al. Thermoresponsive polymeric surfaces, control of attachment and detachment of culture cells. Macromol. Chem. Rapid Commun. 11(11):1990;571-576.
19. Okano T., Yamada N., Sakai H.et al. A novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide). J. Biomed. Mater. Res. 27(10):1993;1243-1251.
20. Okano T., Kikuchi A., Sakurai Y.et al. Temperature-responsive poly(N-isopropylacrylamide) as a modulator for alteration of hydrophilic/hydrophobic surface properties to control activation/inactivation of platelets. J. Control. Rel. 36:1995;125-133.
21. Dong D.C., Winnik M.A. The Py scale of solvent polarities. Can. J. Chem. 62:1984;2560-2565.
22. Zhao C.L., Winnik M.A., Riess G.et al. Fluorescence probe techniques used to study micelle formation in water-soluble block copolymers. Langmuir. 6:1990;514-516.
23. Wilhelm M., Zhao C.L., Wang Y.et al. Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe study. Macromolecules. 24:1991;1033-1040.
24. Okano T., Katayama M., Shinohara I. The influence of hydrophilic and hydrophobic domains of on water wettability of 2-hydroxyethyl methacrylate-styrene copolymers. J. Appl. Polymer Sci. 22:1978;369-377.
25. Takei Y.G., Aoki T., Sanui Ket al. Temperature-responsive bioconjugates. 1. Synthesis of temperature-responsive oligomers with reactive and groups and their coupling to biomolecules. Bioconj. Chem. 4(1):1993;42-46.
26. Ogawa Y., Okada H., Yamamoto M.et al. In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers. Chem. Pharm. Bull. 36(7):1998;2576-2581.
27. Jeong B., Bae Y.H., Lee D.S.et al. Biodegradable block copolymers as injectable drug-delivery systems. Nature. 388(28):1997;860-862.
28. Takei Y.G., Aoki T., Sanui K.et al. Temperature-responsive bioconjugates. 2. Molecular design for temperature-modulated bioseparations. Bioconj. Chem. 4(5):1993;341-346.