Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: Effect on the intracellular drug localization

Journal of Pharmaceutical Sciences

Volumn 91, Issue 1, 2002, Pages 157-170

  Rapoport, Natalya ^a   Marin, Alexander ^a   Luo, Yi ^a   Prestwich, Glenn D ^a   Muniruzzaman, M D ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

A2780 cells; A2780 ADR cells; Drug sensitive cells; Endosomal release; HL 60 cells; Intracellular trafficking; MDR cells; Pluronic micelles

Indexed keywords

DOXORUBICIN; RUBOXYL;

ARTICLE; CELL NUCLEUS; CELL POPULATION; CELL STRAIN HL 60; CYTOPLASM VESICLE; DRUG DISTRIBUTION; ENDOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MICELLE; MULTIDRUG RESISTANCE; OVARY CARCINOMA; ULTRASOUND;

EID: 0036141740     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10006     Document Type: Article

References (28)

1. Conjugates of anticancer agents and polymers: Advantages of macromolecular therapeutics in vivo
2. Block copolymer micelles as long circulating drug vehicles
3. Doxorubicin-loaded poly(ethylene glycol)-poly(b-benzyl-L-aspartate) copolymer micelles: Their pharmaceutical characteristics and biological significance
4. Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery
5. Pluronic micelles as vehicles for tumor-specific delivery of two anticancer drugs to HL-60 cells using acoustic activation
6. Intracellular distribution and intracellular dynamics of a spin-labeled analogue of doxorubicin by fluorescence and EPR spectroscopy
7. Ultrasonic activated drug delivery from Pluronic P-105 micelles
8. Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60: Effect of micelle structure and ultrasound on the intracellular drug uptake
9. Factor affecting acoustically triggered release of drugs from polymeric micelles
10. Effect of a polymeric surfactant on electron transport in HL-60 cells
11. Acoustic activation of drug delivery from polymeric micelles: Effect of pulsed ultrasound
12. Mechanism of the ultrasound activation of micellar drug delivery
13. Intracellular uptake of Pluronic unimers and micelles: Effect of the aggregation state and ultrasound
14. Inhibition of multidrug resistance-associated protein (MPR) functional activity with pluronic block copolymers
15. Polymers help guide cancer drugs to tumor targets- and keep them there
16. +-ATPase-dependent activity of multidrug resistance-associated protein in homoharringtonine-resistant human leukemic K562 cells
17. Defective acidification in human breast tumor cells and implications for chemotherapy
18. Enhancement of the polycation-mediated DNA uptake and cell transfection with Pluronic P85 block copolymer
19. A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle
20. Block and graft copolymers and nanogel copolymer networks for DNA delivery into cell
21. Block copolymer based formulation of doxorubicin. From cell screen to clinical trials
22. Hypersensitization of multi-drug resistant human ovarian carcinoma cells by Pluronic P85 block copolymer
23. Hypersensitizing effect of Pluronic L61 on cytoxic activity, transport and subcellular distribution of doxorubicin in multiple drug-resistant cells
24. Pluronic P85 increases permeability of a broad spectrum of drugs in polarized BBMEC and Caco-2 cell monolayers
25. Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells
26. Polymeric systems for controlled drug release
27. Micellization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association