PCL-b-PEO micelles as a delivery vehicle for FK506: Assessment of a functional recovery of crushed peripheral nerve

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 7, Issue 3, 2000, Pages 139-145

  Allen, C ^a   Eisenberg, A ^a   Mrsic, J ^a   Maysinger, D ^a  

^a Dept of Pharmacol/Therapeut ^*  (Canada)

Author keywords

Block Copolymer Micelles; Crushed Sciatic Nerve; In Vitro Release; Tacrolimus

Indexed keywords

COPOLYMER; DRUG VEHICLE; MACROGOL; POLYCAPROLACTONE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ISOTOPE LABELING; LIPOPHILICITY; MALE; MICELLE; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0033816615     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540050120179     Document Type: Article

References (29)

1. Polycaprolactone-b-poly(ethylene oxide) block copolymer micelles as a novel drug delivery vehicle for neurotrophic agents FK506 and L-685,818
2. Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone
3. Nano-engineering copolymer aggregates for drug delivery
4. The immunophilins, FK506 binding protein and cyclophilin are discretely localized in the brain: Relationship to calcineurin
5. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
6. The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve
7. The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury
8. Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration
9. A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration
10. FK506 historical perspectives
11. Neuroimmunophilin ligands as novel therapeutics for the treatment of degenerative disorders of the nervous system
12. Comparative study of cyclosporin and FK506 dosage requirements in adults and pediatric orthotopic liver transplant patients
13. Polymeric micelles - A new generation of colloidal drug carriers
14. Predominant role of local immunosuppressive effect in enhanced efficacy of liposomal FK506 in organ transplantation
15. The enhanced immunosuppressive efficacy of newly developed liposomal FK506 in canine liver transplantation
16. The pharmacokinetic benefits of newly developed liposome-incorporated FK506
17. FK506 promotes functional recovery in crushed rat sciatic nerve
18. Immunosuppresant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia
19. Development of pharmacological agents for targeting neurotrophins and their receptors
20. Immunophilins and the nervous system
21. Neural actions of immunophilin ligands
22. Neurotrophic actions on nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A
23. High brain densities of the immunophilin FKBP colocalized with calcineurin
24. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
25. Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enternal route
26. The pharmacokinetics of water-in-oil-type multiple emulsion of a new tacrolimus formulation
27. Pharmacokinetics of FK506: Preclinical and clinical studies
28. Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve
29. Synthesis and pharmacokinetics of a novel macromolecular prodrug of tacrolimus (FK506), FK506-dextran conjugate