Effect of molecular weight of thermoreversible polymer on in vivo retention of rhBMP-2

Journal of Biomedical Materials Research

Volumn 57, Issue 1, 2001, Pages 92-100

  Gao, Tiejun ^a   Uludag, Hasan ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Gel microstructure; In vivo retention; Molecular weight; Recombinant human bone morphogenetic protein 2; Thermoreversible polymers

Indexed keywords

BONE; MOLECULAR WEIGHT; ORGANIC POLYMERS; PROTEINS;

CONJUGATIONS; THERMOREVERSIBLE POLYMERS;

BIOMATERIALS;

ACRYLAMIDE DERIVATIVE; METHACRYLIC ACID DERIVATIVE; POLYMER; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; BONE REGENERATION; CHEMICAL STRUCTURE; CONJUGATION; CROSS LINKING; HYDROGEL; MICELLE; MOLECULAR WEIGHT; POLYMERIZATION; PROTEIN TRANSPORT; SOLUBILITY; TEMPERATURE DEPENDENCE;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REMODELING; DRUG DELIVERY SYSTEMS; HUMANS; MOLECULAR WEIGHT; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034937692     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4636(200110)57:1<92::AID-JBM1146>3.0.CO;2-1     Document Type: Article

References (24)

1. Novel regulators of bone formation: Molecular clones and activities
2. Bone morphogenetic protein-2
3. A feasibility study evaluation rhBMP-2/absorbable collagen sponge for maxillary sinus augmentation
4. The effect of human recombinant osteogenic protein-1 on healing of large segmental bone defects
5. Searching for a novel carrier for bioactive delivery of bone morphogenetic proteins
6. Sustained release emphasizing recombinant human bone morphogenetic protein-2
7. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery
8. Heparin release from thermosensitive polymer coatings: In vitro studies
9. In vitro studies on a new method for islet microencapsulation using a thermoreversible gelation polymer, N-isopropylacrylamide-based copolymer
10. Synthesis and characterization of injectable poly(N-isopropylacrylamide)-based hydrogels that support tissue formation in vitro
11. Synthetic thermoreversible polymers are compatible with osteoinductive activity of rhBMP-2
12. Engineering temperature-sensitive poly(N-isopropylacrylamide) polymers as carriers of therapeutic proteins
13. Reactivity of temperature-sensitive, protein-conjugating polymers prepared by a photopolymerization process
14. Synthesis and characterization of thermoreversible, protein-conjugating copolymers based on N-isopropylacrylamide
15. A spectrophotometric assay for soluble and immobilized N-hydroxysuccinimide esters
16. Size-exclusion chromatography with on-line light-scattering, absorbance, and refractive index detectors for studying proteins and their interactions
17. Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model
18. Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model
19. Manipulation of the rate of hydrolysis of polymer-drug conjugates: The degree of hydration
20. Polymer-drug conjugates: Manipulating drug delivery kinetics using model LCST systems
21. Poly(N-isopropylacrylamide): Experiment, theory, and application
22. Polymer molecular weight alters properties of pH/temperature-sensitive polymer beads
23. Entanglement effects in polymer solution
24. Enhanced in vivo retention of rhBMP-2 by thermoreversible polymers