-
1
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
2
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
3
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 2002; 14: 381-395.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
4
-
-
0038335334
-
PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling
-
Paez J, Sellers WR. PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res 2003; 115: 145-167.
-
(2003)
Cancer Treat Res
, vol.115
, pp. 145-167
-
-
Paez, J.1
Sellers, W.R.2
-
5
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001; 98: 10983-10985.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
6
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivaneo I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivaneo, I.1
Sawyers, C.L.2
-
7
-
-
0023945139
-
Thymic lymphoma induction by the AKT8 murine retrovirus
-
Staal SP, Hartley JW. Thymic lymphoma induction by the AKT8 murine retrovirus. J Exp Med 1988; 167: 1259-1264.
-
(1988)
J Exp Med
, vol.167
, pp. 1259-1264
-
-
Staal, S.P.1
Hartley, J.W.2
-
8
-
-
0035413599
-
Phosphoinositide-regulated kinases and phosphoinositide phosphatases
-
Leslie NR, Biondi RM, Alessi DR. Phosphoinositide-regulated kinases and phosphoinositide phosphatases. Chem Rev 2001; 101: 2365-2380.
-
(2001)
Chem Rev
, vol.101
, pp. 2365-2380
-
-
Leslie, N.R.1
Biondi, R.M.2
Alessi, D.R.3
-
9
-
-
0030590875
-
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
-
Alessi DR et al. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 1996; 399: 333-338.
-
(1996)
FEBS Lett
, vol.399
, pp. 333-338
-
-
Alessi, D.R.1
-
10
-
-
0035499454
-
Ten years of protein kinase B signalling: A hard Akt to follow
-
Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci 2001; 26: 657-664.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 657-664
-
-
Brazil, D.P.1
Hemmings, B.A.2
-
11
-
-
9144270454
-
Regulation of tumor angiogenesis by integrin-linked kinase (ILK)
-
Tan C., et al. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 2004; 5: 79-90.
-
(2004)
Cancer Cell
, vol.5
, pp. 79-90
-
-
Tan, C.1
-
12
-
-
0037666792
-
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
-
Troussard AA et al. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 2003; 278: 22374-22378.
-
(2003)
J Biol Chem
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
-
13
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A, Pandolfi PP The multiple roles of PTEN in tumor suppression. Cell 2000; 100: 387-390.
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
14
-
-
0033856110
-
PTEN, a unique tumor-suppressor gene
-
Dahia PL. PTEN, a unique tumor-suppressor gene. Endocr Relat Cancer 2000; 7: 115-129.
-
(2000)
Endocr Relat Cancer
, vol.7
, pp. 115-129
-
-
Dahia, P.L.1
-
15
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/ AKT pathway. Proc Natl Acad Sci USA 1999; 96: 4240-4245.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
16
-
-
0036181869
-
PTEN: The down side of PI 3-kinase signalling
-
Leslie NR, Downes CE PTEN: The down side of PI 3-kinase signalling. Cell Signal 2002; 14: 285-295.
-
(2002)
Cell Signal
, vol.14
, pp. 285-295
-
-
Leslie, N.R.1
Downes, C.E.2
-
17
-
-
0037081563
-
Protein phosphatase 1 - Targeted in many directions
-
Cohen PT. Protein phosphatase 1 - targeted in many directions. J Cell Sci 2002; 115: 241-256.
-
(2002)
J Cell Sci
, vol.115
, pp. 241-256
-
-
Cohen, P.T.1
-
18
-
-
0035252894
-
Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
-
Janssens V, Goris J. Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001; 353: 417-439.
-
(2001)
Biochem J
, vol.353
, pp. 417-439
-
-
Janssens, V.1
Goris, J.2
-
19
-
-
0035840446
-
Role of serine/threonine protein phosphatase 2A in cancer
-
Schonthal AH. Role of serine/threonine protein phosphatase 2A in cancer. Cancer Lett 2001; 170: 1-13.
-
(2001)
Cancer Lett
, vol.170
, pp. 1-13
-
-
Schonthal, A.H.1
-
20
-
-
0033152165
-
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
-
Davies MA et al. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 1999; 59: 2551-2556.
-
(1999)
Cancer Res
, vol.59
, pp. 2551-2556
-
-
Davies, M.A.1
-
22
-
-
0036154215
-
Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
-
Resjo S., et al. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell Signal 2002; 14: 231-238.
-
(2002)
Cell Signal
, vol.14
, pp. 231-238
-
-
Resjo, S.1
-
23
-
-
0036170771
-
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta
-
Ivaska J et al. Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Mol Cell Biol 2002; 22: 1352-1359.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1352-1359
-
-
Ivaska, J.1
-
24
-
-
0037131377
-
N-ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A
-
Yellaturu CR, Bhanoori M, Neeli I, Rao GN. N-ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem 2002; 277: 40148-40155.
-
(2002)
J Biol Chem
, vol.277
, pp. 40148-40155
-
-
Yellaturu, C.R.1
Bhanoori, M.2
Neeli, I.3
Rao, G.N.4
-
25
-
-
0035513703
-
Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
-
Teruel T, Hernandez R, Lorenzo M. Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 2001; 50: 2563-2571.
-
(2001)
Diabetes
, vol.50
, pp. 2563-2571
-
-
Teruel, T.1
Hernandez, R.2
Lorenzo, M.3
-
26
-
-
0035487315
-
A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
-
Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C. A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 2001; 50: 2210-2218.
-
(2001)
Diabetes
, vol.50
, pp. 2210-2218
-
-
Cazzolli, R.1
Carpenter, L.2
Biden, T.J.3
Schmitz-Peiffer, C.4
-
27
-
-
0035011210
-
Caveolin-1 expression in advanced-stage ovarian carcinoma - A clinicopathologic study
-
Davidson B., et al. Caveolin-1 expression in advanced-stage ovarian carcinoma - a clinicopathologic study. Gynecol Oncol 2001; 81: 166-171.
-
(2001)
Gynecol Oncol
, vol.81
, pp. 166-171
-
-
Davidson, B.1
-
28
-
-
0035153475
-
Elevated expression of caveolin-1 in adenocarcinoma of the colon
-
Fine SW, Lisanti MP, Galbiati F, Li M. Elevated expression of caveolin-1 in adenocarcinoma of the colon. Am J Clin Pathol 2001; 115: 719-724.
-
(2001)
Am J Clin Pathol
, vol.115
, pp. 719-724
-
-
Fine, S.W.1
Lisanti, M.P.2
Galbiati, F.3
Li, M.4
-
29
-
-
0034871794
-
Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells
-
Goh M et al. Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells. Neoplasia 2001; 3: 331-338.
-
(2001)
Neoplasia
, vol.3
, pp. 331-338
-
-
Goh, M.1
-
30
-
-
0036841790
-
Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation
-
Ho CC et al. Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation. Am J Pathol 2002; 161: 1647-1656.
-
(2002)
Am J Pathol
, vol.161
, pp. 1647-1656
-
-
Ho, C.C.1
-
31
-
-
0035175805
-
Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: Overexpression of oncogene MET correlates with tumor differentiation in ESCC
-
Hu YC et al. Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: Overexpression of oncogene MET correlates with tumor differentiation in ESCC. Clin Cancer Res 2001; 7: 3519-3525.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3519-3525
-
-
Hu, Y.C.1
-
32
-
-
18344365571
-
Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid
-
Ito Y et al. Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid. Br J Cancer 2002; 86: 912-916.
-
(2002)
Br J Cancer
, vol.86
, pp. 912-916
-
-
Ito, Y.1
-
33
-
-
0037083622
-
Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
-
Kato K et al. Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Cancer 2002; 94: 929-933.
-
(2002)
Cancer
, vol.94
, pp. 929-933
-
-
Kato, K.1
-
34
-
-
0037458621
-
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells
-
Podar K et al. Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem 2003; 278: 5794-5801.
-
(2003)
J Biol Chem
, vol.278
, pp. 5794-5801
-
-
Podar, K.1
-
35
-
-
0035515318
-
Caveolin-1 expression is associated with high-grade bladder cancer
-
Rajjayabun PH et al. Caveolin-1 expression is associated with high-grade bladder cancer. Urology 2001; 58: 811-814.
-
(2001)
Urology
, vol.58
, pp. 811-814
-
-
Rajjayabun, P.H.1
-
36
-
-
18744386654
-
Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma
-
Suzuoki M et al. Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br J Cancer 2002; 87: 1140-1144.
-
(2002)
Br J Cancer
, vol.87
, pp. 1140-1144
-
-
Suzuoki, M.1
-
37
-
-
0033794201
-
Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells
-
Tso CL et al. Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells. Cancer J 2000; 6: 220-233.
-
(2000)
Cancer J
, vol.6
, pp. 220-233
-
-
Tso, C.L.1
-
38
-
-
0037089018
-
Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer
-
Wu D et al. Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res 2002; 62: 2423-2429.
-
(2002)
Cancer Res
, vol.62
, pp. 2423-2429
-
-
Wu, D.1
-
39
-
-
0031763007
-
Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells
-
Yang CP et al. Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells. FEBS Lett 1998; 439: 368-372.
-
(1998)
FEBS Lett
, vol.439
, pp. 368-372
-
-
Yang, C.P.1
-
40
-
-
0033571471
-
Caveolin-1 expression m clinically confined human prostate cancer: A novel prognostic marker
-
Yang G, Truong LD, Wheeler TM, Thompson TC. Caveolin-1 expression m clinically confined human prostate cancer: A novel prognostic marker. Cancer Res 1999; 59: 5719-5723.
-
(1999)
Cancer Res
, vol.59
, pp. 5719-5723
-
-
Yang, G.1
Truong, L.D.2
Wheeler, T.M.3
Thompson, T.C.4
-
41
-
-
0345491598
-
Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A
-
Li L et al. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol Cell Biol 2003; 23: 9389-9404.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 9389-9404
-
-
Li, L.1
-
42
-
-
0030941001
-
Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins
-
Couet J et al. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem 272: 6525-6533.
-
J Biol Chem
, vol.272
, pp. 6525-6533
-
-
Couet, J.1
-
43
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell 2003 4: 257-262.
-
(2003)
Cancer Cell
, vol.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
44
-
-
0034680838
-
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
-
Obata T et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem 2000; 275: 36108-36115.
-
(2000)
J Biol Chem
, vol.275
, pp. 36108-36115
-
-
Obata, T.1
-
45
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 1999; 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
-
46
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
-
47
-
-
0035936023
-
The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change
-
Yamaguchi H, Wang HG. The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene 2001; 20: 7779-7786.
-
(2001)
Oncogene
, vol.20
, pp. 7779-7786
-
-
Yamaguchi, H.1
Wang, H.G.2
-
48
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
-
49
-
-
0027433708
-
Phosphorylated CREB binds specifically to the nuclear protein CBP
-
Chrivia JC et al. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993; 365: 855-859.
-
(1993)
Nature
, vol.365
, pp. 855-859
-
-
Chrivia, J.C.1
-
50
-
-
0029810469
-
Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis
-
Wilson BE, Mochon E, Boxer LM. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis. Mol Cell Biol 1996; 16: 5546-5556.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5546-5556
-
-
Wilson, B.E.1
Mochon, E.2
Boxer, L.M.3
-
51
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999; 401: 86-90.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
52
-
-
0034859101
-
The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling
-
Grimes CA Jope RS. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling. Prog Neurobiol 2001 65: 391-426.
-
(2001)
Prog Neurobiol
, vol.65
, pp. 391-426
-
-
Grimes, C.A.1
Jope, R.S.2
-
53
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
Kim AH et al. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893-901.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
-
54
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo LD, Donner DB. A phosphatidylinositol 3-kinase/Akt pathway translocation of Mdm2 from the cytoplasm to the nucleus. Proc Natl Acad Sci USA 2001; 98: 11598-11603.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
55
-
-
0035863411
-
AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells
-
Tanno S et al. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001; 61: 589-593.
-
(2001)
Cancer Res
, vol.61
, pp. 589-593
-
-
Tanno, S.1
-
56
-
-
0034954054
-
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells
-
Thant AA et al. Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Clin Exp Metastasis 2000; 18: 423-428.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 423-428
-
-
Thant, A.A.1
-
57
-
-
0036527350
-
Dissection of angiogemc signaling in zebrafish using a chemical genetic approach
-
Chan J, Bayliss PE, Wood JM, Roberts TM. Dissection of angiogemc signaling in zebrafish using a chemical genetic approach. Cancer Cell 2002; 1: 257-267.
-
(2002)
Cancer Cell
, vol.1
, pp. 257-267
-
-
Chan, J.1
Bayliss, P.E.2
Wood, J.M.3
Roberts, T.M.4
-
58
-
-
0036345949
-
Transition to androgen-independence in prostate cancer
-
Navarro D et al. Transition to androgen-independence in prostate cancer J Steroid Biochem Mol Biol 2002; 81: 191.
-
(2002)
J Steroid Biochem Mol Biol
, vol.81
, pp. 191
-
-
Navarro, D.1
-
59
-
-
0036645414
-
Molecular biology of the androgen receptor
-
Gelmann EP. Molecular biology of the androgen receptor. J Clin Oncol 2002; 20: 3001-3015.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3001-3015
-
-
Gelmann, E.P.1
-
60
-
-
0035912833
-
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor
-
Lin HK, Yeh S, Kang HY, Chang C. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci USA 2001; 98: 7200-7205.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7200-7205
-
-
Lin, H.K.1
Yeh, S.2
Kang, H.Y.3
Chang, C.4
-
61
-
-
0034671668
-
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway
-
Wen Y et al. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res 2000; 60: 6841-6845.
-
(2000)
Cancer Res
, vol.60
, pp. 6841-6845
-
-
Wen, Y.1
-
62
-
-
19044380048
-
Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites
-
Gioeli D et al. Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem 2002; 277: 29304-29314.
-
(2002)
J Biol Chem
, vol.277
, pp. 29304-29314
-
-
Gioeli, D.1
-
63
-
-
0035918165
-
Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation
-
Lu ML et al. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem 2001; 276: 13442-13451.
-
(2001)
J Biol Chem
, vol.276
, pp. 13442-13451
-
-
Lu, M.L.1
-
64
-
-
0041691050
-
Androgen receptors in prostate cancer
-
Culig Z et al. Androgen receptors in prostate cancer. J Urol 2003; 170: 1363-1369.
-
(2003)
J Urol
, vol.170
, pp. 1363-1369
-
-
Culig, Z.1
-
65
-
-
3042522791
-
The androgen receptor in hormone-refractory prostate cancer: Relevance of different mechanisms of androgen receptor signaling
-
(Review)
-
Cronauer MV et al. The androgen receptor in hormone-refractory prostate cancer: Relevance of different mechanisms of androgen receptor signaling (Review). Int J Oncol 2003; 23: 1095-1102.
-
(2003)
Int J Oncol
, vol.23
, pp. 1095-1102
-
-
Cronauer, M.V.1
-
66
-
-
0036645414
-
Molecular biology of the androgen receptor
-
Gelmann EE Molecular biology of the androgen receptor. J Clin Oncol 2002; 20: 3001-3015.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3001-3015
-
-
Gelmann, E.E.1
-
67
-
-
0033146755
-
Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators
-
Yeh S et al. Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. Keio J Med 1999; 48: 87-92.
-
(1999)
Keio J Med
, vol.48
, pp. 87-92
-
-
Yeh, S.1
-
68
-
-
0035555872
-
Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer
-
Gnanapragasam VJ et al. Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Br J Cancer 2001; 85: 1928-1936.
-
(2001)
Br J Cancer
, vol.85
, pp. 1928-1936
-
-
Gnanapragasam, V.J.1
-
69
-
-
0142059907
-
Role of the steroid receptor coactivator SRC-3 in cell growth
-
Zhou G et al. Role of the steroid receptor coactivator SRC-3 in cell growth. Mol Cell Biol 2003; 23: 7742-7755.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7742-7755
-
-
Zhou, G.1
-
70
-
-
0036312303
-
Novel targets of Akt, p21(Cipl/WAF1), and MDM2
-
Zhou BP, Hung MC. Novel targets of Akt, p21(Cipl/WAF1), and MDM2. Semin Oncol 2002; 29: 62-70.
-
(2002)
Semin Oncol
, vol.29
, pp. 62-70
-
-
Zhou, B.P.1
Hung, M.C.2
-
71
-
-
18644370396
-
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) bay PKB/Akt-mediated phosphorylation in breast cancer
-
Viglietto G et al. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) bay PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002; 8: 1136-1144.
-
(2002)
Nat Med
, vol.8
, pp. 1136-1144
-
-
Viglietto, G.1
-
72
-
-
0034637524
-
Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression
-
Graft JR et al. Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J Biol Chem 2000; 275: 24500-24505
-
(2000)
J Biol Chem
, vol.275
, pp. 24500-24505
-
-
Graft, J.R.1
-
73
-
-
0035902115
-
Proliferation, cell cycle and apoptosis in cancer
-
Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001; 411: 342-348.
-
(2001)
Nature
, vol.411
, pp. 342-348
-
-
Evan, G.I.1
Vousden, K.H.2
-
74
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103: 253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
75
-
-
0033527577
-
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells
-
Altiok S et al. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. J Biol Chem 1999; 274: 32274-32278.
-
(1999)
J Biol Chem
, vol.274
, pp. 32274-32278
-
-
Altiok, S.1
-
76
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
Dimmeler S et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-605.
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
-
77
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
Fulton D et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597-601.
-
(1999)
Nature
, vol.399
, pp. 597-601
-
-
Fulton, D.1
-
78
-
-
0033618371
-
Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines
-
Nakatani K et al. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999; 274: 21528-21532.
-
(1999)
J Biol Chem
, vol.274
, pp. 21528-21532
-
-
Nakatani, K.1
-
79
-
-
0242525635
-
Gene amplifications associated with the development of hormone-resistant prostate cancer
-
Edwards J, Krishna NS, Witton CJ, Bartlett JM. Gene amplifications associated with the development of hormone-resistant prostate cancer. Clin Cancer Res 2003; 9: 5271-5281.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5271-5281
-
-
Edwards, J.1
Krishna, N.S.2
Witton, C.J.3
Bartlett, J.M.4
-
80
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
Bellacosa A et al. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas. Int J Cancer 1995; 64: 280-285.
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
-
81
-
-
0026667730
-
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
-
Cheng JQ et al. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992; 89: 9267-9271.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9267-9271
-
-
Cheng, J.Q.1
-
82
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
Cheng JQ et al. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996; 93: 3636-3641.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3636-3641
-
-
Cheng, J.Q.1
-
83
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987; 84: 5034-5037.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
84
-
-
0035881322
-
Overexpression and overactivation of Akt in thyroid carcinoma
-
Ringel MD et al. Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res 2001; 61: 6105-6111.
-
(2001)
Cancer Res
, vol.61
, pp. 6105-6111
-
-
Ringel, M.D.1
-
85
-
-
0034742120
-
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 2001; 159: 431-437.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
-
86
-
-
0142117190
-
Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer
-
Liao Y et al. Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer. Int J Cancer 2003; 107: 676-680.
-
(2003)
Int J Cancer
, vol.107
, pp. 676-680
-
-
Liao, Y.1
-
87
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999; 21: 99-102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
-
88
-
-
0035886016
-
The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
-
Philp AJ et al. The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 2001; 61: 7426-7429.
-
(2001)
Cancer Res
, vol.61
, pp. 7426-7429
-
-
Philp, A.J.1
-
89
-
-
1242338152
-
The HER receptor family: A rich target for therapeutic development
-
Mass RD. The HER receptor family: A rich target for therapeutic development. Int J Radiat Oncol Biol Phys 2004; 58: 932-940.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 932-940
-
-
Mass, R.D.1
-
90
-
-
0034474313
-
A potential role for activated HER-2 in prostate cancer
-
discussion 92-100
-
Agus DB et al. A potential role for activated HER-2 in prostate cancer. Semin Oncol 2000; 27: 7643, discussion 92-100.
-
(2000)
Semin Oncol
, vol.27
, pp. 7643
-
-
Agus, D.B.1
-
91
-
-
2442701289
-
The ErbB/HER receptor protein-tyrosine kinases and cancer
-
Roskoski Jr R. The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem Biophys Res Commun 2004; 319: 1-11.
-
(2004)
Biochem Biophys Res Commun
, vol.319
, pp. 1-11
-
-
Roskoski Jr., R.1
-
93
-
-
0041914332
-
The role of PTEN in the progression and survival of prostate cancer
-
Deocampo ND, Huang H, Tindall DJ. The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol 2003; 28: 145-153.
-
(2003)
Minerva Endocrinol
, vol.28
, pp. 145-153
-
-
Deocampo, N.D.1
Huang, H.2
Tindall, D.J.3
-
94
-
-
0031710623
-
Chromosome 10 alterations in prostate adenocarcinoma
-
(review)
-
Ittmann MM. Chromosome 10 alterations in prostate adenocarcinoma (review). Oncol Rep 1998; 5: 1329-1335.
-
(1998)
Oncol Rep
, vol.5
, pp. 1329-1335
-
-
Ittmann, M.M.1
-
95
-
-
0033579163
-
Mutational spectra of PTEN/MMAC1 gene: A tumor-suppressor with lipid phosphatase activity
-
Ali IU, Schriml LM, Dean M. Mutational spectra of PTEN/MMAC1 gene: A tumor-suppressor with lipid phosphatase activity. J Natl Cancer Inst 1999; 91: 1922-1932.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1922-1932
-
-
Ali, I.U.1
Schriml, L.M.2
Dean, M.3
-
96
-
-
0035740250
-
Chromosomal deletions and tumor-suppressor genes in prostate cancer
-
Dong JT. Chromosomal deletions and tumor-suppressor genes in prostate cancer. Cancer Metastasis Rev 2001; 20: 173-193.
-
(2001)
Cancer Metastasis Rev
, vol.20
, pp. 173-193
-
-
Dong, J.T.1
-
97
-
-
0034796233
-
Loss of heterozygosity and microsatellite instability at chromosomal sites 1Q and 10Q in morphologically distinct regions of late stage prostate lesions
-
Latini JM et al. Loss of heterozygosity and microsatellite instability at chromosomal sites 1Q and 10Q in morphologically distinct regions of late stage prostate lesions. J Urol 2001; 166: 1931-1936.
-
(2001)
J Urol
, vol.166
, pp. 1931-1936
-
-
Latini, J.M.1
-
98
-
-
0034075812
-
10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer
-
Rubin MA et al. 10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer. Hum Pathol 2000; 31: 504-508.
-
(2000)
Hum Pathol
, vol.31
, pp. 504-508
-
-
Rubin, M.A.1
-
99
-
-
0031762207
-
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN
-
Gray IC et al. Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN. Br J Cancer 1998; 78: 1296-1300.
-
(1998)
Br J Cancer
, vol.78
, pp. 1296-1300
-
-
Gray, I.C.1
-
100
-
-
0032482369
-
PTEN/MMAC1/TEP1 involvement in primary prostate cancers
-
Pesche S et al. PTEN/MMAC1/TEP1 involvement in primary prostate cancers. Oncogene 1998; 16: 2879-2883.
-
(1998)
Oncogene
, vol.16
, pp. 2879-2883
-
-
Pesche, S.1
-
101
-
-
0032473921
-
Analysis of PTEN and the 10q23 region in primary prostate carcinomas
-
Feilotter HE et al. Analysis of PTEN and the 10q23 region in primary prostate carcinomas. Oncogene 1998; 16: 1743-1748.
-
(1998)
Oncogene
, vol.16
, pp. 1743-1748
-
-
Feilotter, H.E.1
-
102
-
-
0035126875
-
Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients
-
Dong JT, Li CL, Sipe TW, Frierson Jr HF. Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients. Clin Cancer Res 2001; 7: 304-308.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 304-308
-
-
Dong, J.T.1
Li, C.L.2
Sipe, T.W.3
Frierson Jr., H.F.4
-
104
-
-
0032804575
-
Epigenetic mechanisms for progression of prostate cancer
-
Rennie PS, Nelson CC. Epigenetic mechanisms for progression of prostate cancer. Cancer Metastasis Rev 1998; 17: 401-409.
-
(1998)
Cancer Metastasis Rev
, vol.17
, pp. 401-409
-
-
Rennie, P.S.1
Nelson, C.C.2
-
105
-
-
0032574718
-
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Whang YE et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 1998; 95: 5246-5250.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
-
106
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang S et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003; 4: 209-221.
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
-
107
-
-
0036847690
-
Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
-
Yang G et al. Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin Cancer Res 2002; 8: 3419-3426.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3419-3426
-
-
Yang, G.1
-
108
-
-
0033200172
-
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
-
McMenamin ME et al. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999; 59: 4291-4296.
-
(1999)
Cancer Res
, vol.59
, pp. 4291-4296
-
-
McMenamin, M.E.1
-
109
-
-
0032500792
-
Alterations of the PPP2R1B gene in human lung and colon cancer
-
Wang SS et al. Alterations of the PPP2R1B gene in human lung and colon cancer. Science 1998; 282: 284-287.
-
(1998)
Science
, vol.282
, pp. 284-287
-
-
Wang, S.S.1
-
110
-
-
0034708257
-
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the sefine-threonine phosphatase 2A in human neoplasms
-
Calin GA et al. Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the sefine-threonine phosphatase 2A in human neoplasms. Oncogene 2000; 19: 1191-1195.
-
(2000)
Oncogene
, vol.19
, pp. 1191-1195
-
-
Calin, G.A.1
-
111
-
-
0035810043
-
Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene
-
Ruediger R, Pham HT, Walter G. Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene 2001; 20: 1892-1899.
-
(2001)
Oncogene
, vol.20
, pp. 1892-1899
-
-
Ruediger, R.1
Pham, H.T.2
Walter, G.3
-
112
-
-
0035804217
-
Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene
-
Ruediger R, Pham HT, Walter G. Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene. Oncogene 2001; 20: 10-15.
-
(2001)
Oncogene
, vol.20
, pp. 10-15
-
-
Ruediger, R.1
Pham, H.T.2
Walter, G.3
-
113
-
-
0035216768
-
The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization
-
Deichmann M et al. The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization. Melanoma Res 2001; 11: 577-585.
-
(2001)
Melanoma Res
, vol.11
, pp. 577-585
-
-
Deichmann, M.1
-
114
-
-
0033630808
-
Role of pRB dephosphorylation in cell cycle regulation
-
Tamrakar S, Rubin E, Ludlow JW. Role of pRB dephosphorylation in cell cycle regulation. Front Biosci 2000; 5: D121-D137.
-
(2000)
Front Biosci
, vol.5
-
-
Tamrakar, S.1
Rubin, E.2
Ludlow, J.W.3
-
115
-
-
0035318367
-
Genetic alterations and expression of the protein phosphatase 1 genes in human cancers
-
Takakura S et al. Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Int J Oncol 2001; 18: 817-824.
-
(2001)
Int J Oncol
, vol.18
, pp. 817-824
-
-
Takakura, S.1
-
116
-
-
0033198362
-
Alterations of the PPP1R3 gene in human cancer
-
Kohno T et al. Alterations of the PPP1R3 gene in human cancer. Cancer Res 1999; 59: 4170-4174.
-
(1999)
Cancer Res
, vol.59
, pp. 4170-4174
-
-
Kohno, T.1
-
117
-
-
5144228549
-
High levels of phosphorylated form of Akt-1 in prostate cancer and nonneoplastic tissues are strong predictors of biochemical recurrence
-
Ayala G et al. High levels of phosphorylated form of Akt-1 in prostate cancer and nonneoplastic tissues are strong predictors of biochemical recurrence. Clinic Cancer Res 2004; 10: 6572-6578.
-
(2004)
Clinic Cancer Res
, vol.10
, pp. 6572-6578
-
-
Ayala, G.1
-
118
-
-
0036168948
-
Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models
-
Hu L et al. Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer Res 2002; 62: 1087-1092.
-
(2002)
Cancer Res
, vol.62
, pp. 1087-1092
-
-
Hu, L.1
-
119
-
-
0032561389
-
Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity
-
Eaton SR et al. Design of peptidomimetics that inhibit the association of phosphatidylinositol 3-kinase with platelet-derived growth factor-beta receptor and possess cellular activity. J Med Chem 1998; 41: 4329-342.
-
(1998)
J Med Chem
, vol.41
, pp. 4329-4342
-
-
Eaton, S.R.1
-
120
-
-
0037419785
-
Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
-
Kozikowski AP, Sun H, Brognard J, Dennis PA. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J Am Chem Soc 2003; 125: 1144-1145.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 1144-1145
-
-
Kozikowski, A.P.1
Sun, H.2
Brognard, J.3
Dennis, P.A.4
-
121
-
-
0037162293
-
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphalidylinositol (3,4,5)-trisphosphate
-
Thomas CC, Deak M, Alessi DR, van Aalten DM. High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphalidylinositol (3,4,5)-trisphosphate. Curr Biol 2002; 12: 1256-1262.
-
(2002)
Curr Biol
, vol.12
, pp. 1256-1262
-
-
Thomas, C.C.1
Deak, M.2
Alessi, D.R.3
van Aalten, D.M.4
-
122
-
-
0034845958
-
PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
-
Lawlor MA, Alessi DR. PKB/Akt: A key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001; 114: 2903-2910.
-
(2001)
J Cell Sci
, vol.114
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
123
-
-
12444333159
-
Development of an immunoassay for serum caveolin-l: A novel biomarker for prostate cancer
-
Tahir SA et al. Development of an immunoassay for serum caveolin-l: A novel biomarker for prostate cancer. Clin Cancer Res 2003; 9: 3653-3659.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3653-3659
-
-
Tahir, S.A.1
-
124
-
-
0035872436
-
Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer
-
Tahir SA et al. Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer. Cancer Res 2001; 61: 3882-3885.
-
(2001)
Cancer Res
, vol.61
, pp. 3882-3885
-
-
Tahir, S.A.1
-
125
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang S, Houghton PJ. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 2003; 3: 371-377.
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
126
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K et al. mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8: 249-258.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
-
127
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat MS et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-10319.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
-
128
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
-
Podsypanina K et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc Natl Acad Sci USA 2001; 98: 10320-10325.
-
(2001)
Proc. Natl Acad Sci USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
-
129
-
-
0034901515
-
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition
-
Dudkin L et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res 2001; 7: 1758-1764.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1758-1764
-
-
Dudkin, L.1
|