AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

American Journal of Pathology

Volumn 159, Issue 2, 2001, Pages 431-437

  Sun, Mei ^a   Wang, Gen ^a   Paciga, June E ^a   Feldman, Richard I ^b   Yuan, Zeng Qiang ^a   Ma, Xiao Ling ^a   Shelley, Sue A ^a   Jove, Richard ^a   Tsichlis, Philip N ^c   Nicosia, Santo V ^a   Cheng, Jin Q ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b BAYER AG   (Germany)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; BREAST TUMOR; CANCER STAGING; CELL CULTURE; CELL STRAIN 3T3; CELL TRANSFORMATION; ENZYME ACTIVATION; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MOUSE; OVARY TUMOR; PATHOLOGY; PROSTATE TUMOR; WESTERN BLOTTING; CANCER; CARCINOGENESIS; CARCINOGENICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; OVARY CARCINOMA; PRIORITY JOURNAL; PROSTATE CARCINOMA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; NEOPLASM STAGING; OVARIAN NEOPLASMS; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0034742120     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61714-2     Document Type: Article

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