Inhibition of phosphatidylinositol 3′-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models

Cancer Research

Volumn 62, Issue 4, 2002, Pages 1087-1092

  Hu, Limin ^a   Hofmann, Judith ^a   Lu, Yiling ^a   Mills, Gordon B ^a   Jaffe, Robert B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASCITES; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; OVARY CANCER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN TOXICITY; TUMOR GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL DIVISION; CHROMONES; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, NUDE; MORPHOLINES; OVARIAN NEOPLASMS; PACLITAXEL; TUMOR CELLS, CULTURED;

EID: 0036168948     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Purification and characterization of phosphoinositide 3-kinase from rat liver
2. Role of PI3-kinase in mitogenesis
3. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
4. Phosphoinositide kinases
5. PIK3CA is implicated as an oncogene in ovarian cancer
6. Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
7. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin DI expression, in primary epithelial ovarian carcinomas
8. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
9. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
10. New natural products in cancer chemotherapy
11. The taxoids. Comparative clinical pharmacology and therapeutic potential
12. Coupling cell division and cell death to microtubule dynamics
13. Cancer of the ovary
14. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis
15. Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells
16. A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
17. BAD partly reverses paclitaxel resistance in human ovarian cancer cells
18. Regulation of vascular smooth muscle cell apoptosis. Modulation of Bad by a phosphatidylinositol 3-kinase-dependent pathway
19. Apoptosis. A kinase makes good
20. Role of vascular endothelial growth factor in ovarian cancer: Inhibition of ascites formation by immunoneutralization
21. Antitumor activity of paclitaxel against human breast carcinoma xenografts serially transplanted into nude mice
22. Antitumor activity of paclitaxel (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice
23. The intereaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity
24. Ovarian carcinoma: Care and survival in a community-based population
25. Role of abnormalities of PTEN and the phosphatidylinositol 3 kinase pathway in breast and ovarian tumorigenesis, prognosis and therapy
26. Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis
27. Translocation of profilaggrin N-terminal domain into keratinocyte nuclei with fragmented DNA in normal human skin and loricrin keratoderma
28. Apoptosis: The importance of being eaten
29. Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages
30. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
31. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
32. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
33. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
34. Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines
35. Protein kinase B (c-AKT) in phosphatidylinositol-3-OH kinase signal transduction
36. Mechanism of activation and function of protein kinase B
37. Signal transduction pathways that regulate cell survival and cell death
38. Interleukin-3-induced phosphorylation of Bad through the protein kinase Akt
39. Akt phosphorylation couples survival signals to the cell-intrinsic death machinery
40. Controlling cell death
41. Mitochondria as regulators of apoptosis: Doubt no more
42. Mechanisms and consequences of activation of protein kinase B/Akt
43. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
44. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease
45. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells