Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3k-Akt pathways in ovarian cancer cells

Clinical and Experimental Metastasis

Volumn 18, Issue 5, 2000, Pages 423-428

  Thant, Aye Aye ^a   Nawa, Akihiro ^a   Kikkawa, Fumitaka ^a   Ichigotani, Yasukatu ^a   Zhang, Yangying ^a   Sein, Thet Thet ^a   Amin, A R M Ruhul ^a   Hamaguchi, Michinari ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Fibronectin; Invasion; MAPK; Matrix metalloproteinase; Ovarian cancer cells, PI 3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INVASION; CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; METASTASIS; OVARY CANCER; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; BUTADIENES; CHROMONES; ENZYME INHIBITORS; FEMALE; FIBRONECTINS; FLAVONOIDS; HUMANS; INDOLES; MALEIMIDES; MAP KINASE KINASE 1; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MORPHOLINES; NEOPLASM INVASIVENESS; NITRILES; OVARIAN NEOPLASMS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0034954054     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1010921730952     Document Type: Article

References (35)

1. Metastatic potential correlates with enzymatic degradation of basement membrane collagen
2. Tumor invasion and the extracellular matrix
3. Matrix matelloproteinase 2 and in Esophageal cancer: Correlation with organ metastasis
4. Regulatory mechanism of 92-kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells
5. Levels of matrix metalloproteinases in bladder cancer correlated with tumor grade and invasion
6. Elevated level of Mr 92,000 type IV collagenase in human brain tumors
7. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase / collangenase) to the metastatic phenotype in transformed rat embryo cells
8. Secretion of type IV collagenolytic protease and metastatic phenotype: Induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-Ela
9. Increased matrix metalloproteinase 9 activity in human ovarian cancer cells cultured with conditioned medium from human peritoneal tissue
10. Fibronectin secretion from human peritoneal tissue induces Mr 92,000 type IV collagenase expression and invasion in ovarian cancer cell lines
11. Integrins and signal transduction pathways: The road taken
12. Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells
13. Increasing complexity of Ras signaling
14. The pathway to signal acheivement
15. Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells
16. Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed through Ras/MAP Kinase signaling pathways
17. Negative regulation of mitogen-activated protein kinase activation by Integrin αIIβ3 in platelets
18. Regulation of 92 kDa type IV collagenase expression by jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades
19. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion
20. Stimulation of 92-kDa gelatinase B promoter activiti by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
21. Collagenase expression in ovarian cancer cell lines
22. The integrin alpha Vbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin
23. Constitutive activation of MAP Kinase Kinase (MEK1) is critical and sufficient for the activation of MMP-2
24. IL-2 induces β2-integrin adhesion via a wortmannin/ LY294002-sensitive, rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with induction of adhesion, but not mitogenesis
25. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
26. Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src
27. Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1
28. Inhibition of sulfated chitin-derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells
29. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system
30. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
31. Expression of matrilysin mRNA in colorectal adenomas and its induction by truncated fibronectin
32. Fibronectin and fibronectin fragmants modulate the expression of proteinases and proteinase inhibitors in human peritoneal ligament cells
33. Role of phospholipase D in laminin-induced production of gelatinase A (MMP-2) in metastatic cells
34. Structure and function of phosphoinositide 3-kinases
35. Transformation of chicken cells by the gene encoding the catalytic subunit of PI3-kinase