Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt

Journal of the American Chemical Society

Volumn 125, Issue 5, 2003, Pages 1144-1145

  Kozikowski, Alan P ^a   Sun, Haiying ^a   Brognard, John ^b   Dennis, Phillip A ^b  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR CELL LINE;

ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; LUNG NEOPLASMS; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR CELLS, CULTURED;

EID: 0037419785     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0285159     Document Type: Article

References (12)

1. Cohen, P. Nat. Rev. Drug Discov. 2002, 1, 309-315.
2. Vivanco, I.; Sawyers, C. L. Nat. Rev. Cancer 2002, 2, 489-501.
3. Hondal, R. J.; Zhao, Z.; Kravchuk, A. V.; Liao, H.; Riddle, S. R.; Yue, X.; Bruzik, K. S.; Tsai, M. D. Biochemistry 1998, 37, 4568-4580.
4. Kozikowski, A. P.; Qiao, L.; Tückmantel, W.; Powis, G. Tetrahedron 1997, 53, 14903-14914.
5. Brognard, J.; Clark, A. S.; Ni, Y.; Dennis, P. A. Cancer Res. 2001, 61, 3986-3997.
6. Stephens, L.; Anderson, K.; Stokoe, D.; Erdjument-Bromage, H.; Painter, G. F.; Holmes, A. B.; Gaffney, P. R.; Reese, C. B.; McCormick, F.; Tempst, P.; Coadwell, J.; Hawkins, P. T. Science 1998, 279, 710-714.
7. Gingras, A. C.; Kennedy, S. G.; O'Leary, M. A.; Sonenberg, N.; Hay, N. Genes Dev. 1998, 12, 502-513.
8. Burgering, B.; Coffer, P. Nature 1995, 376, 599-602.
9. Kops, G. J.; de Ruiter, N. D.; De Vries-Smits, A. M.; Powell, D. R.; Bos, J. L.; Burgering, B. M. Nature 1999, 398, 630-634.
10. Zimmermann, S.; Moelling, K. Science 1999, 286, 1741-1744.
11. Rommel, C.; Clarke, B. A.; Zimmermann, S.; Nuñez, L.; Rossman, R.; Reid, K.; Moelling, K.; Yancopoulos, G. D.; Glass, D. J. Science 1999, 286, 1738-1741.
12. For a review on antitumor ether lipids, see: Arthur, G.; Bittman, R. Biochim. Biophys. Acta 1998, 1390, 85-102.