The protein phosphatase 2A subunit Bγ gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization

Melanoma Research

Volumn 11, Issue 6, 2001, Pages 577-585

  Deichmann, M ^a   Polychronidis, M ^a   Wacker, J ^a   Thome, M ^a   Naher H ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Gene expression; Malignant melanoma; Protein phosphatase 2A subunit B ; Subtractive suppression hybridization; Tumour suppressor gene

Indexed keywords

CALCINEURIN; COMPLEMENTARY DNA; DNA FRAGMENT; GROWTH FACTOR; ISOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SUBUNIT; SERINE; THREONINE;

ADULT; ARTICLE; BETA SHEET; CASE REPORT; CELL DIVISION; CELL GROWTH; CELLULAR DISTRIBUTION; ENZYME SPECIFICITY; GENE EXPRESSION; GENE REPRESSION; HUMAN; HUMAN TISSUE; HYBRIDIZATION; MALE; MELANOCYTIC NEVUS; MELANOMA; PRIORITY JOURNAL; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

DNA PRIMERS; DNA, NEOPLASM; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LIBRARY; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MELANOMA; MIDDLE AGED; NEVUS, PIGMENTED; PHOSPHOPROTEIN PHOSPHATASE; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SKIN NEOPLASMS;

EID: 0035216768     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008390-200112000-00004     Document Type: Article

References (55)

1. The incidence of malignant melanoma in the United States: Issues as we approach the 21st century
2. Cancer, the rise of the genetic paradigm
3. The chemoresistance of human malignant melanoma: An update
4. N-ras mutations in human cutaneous melanoma from sunexposed body sites
5. Ras gene mutations, a rare event in nonmetastatic primary malignant melanoma
6. Human malignant melanoma, a genetic disease?
7. p53 mutations in cancer
8. p53 gene mutations in human epithelial skin cancers
9. p53 mutations in basal cell carcinomas
10. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers
11. Genetics of melanoma
12. Mutation and expression of the p53 gene in human malignant melanomas
13. Overexpression and mutations of p53 in metastatic melanoma
14. p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanogenesis
15. p53 gene mutation and expression in naevi and melanomas
16. Molecular genetics of familial cutaneous melanoma
17. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
18. Genes involved in melanoma: An overview of INK4a and other loci
19. Infrequent mutation of p16INK4 in sporadic melanoma
20. Homozygous deletion of the p16INK4a and p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma
21. The PTEN/MMAC1 tumour suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene
22. Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
23. Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies
24. The PTEN tumour suppressor gene and malignant melanoma
25. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
26. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
27. Evolutionary conservation in the untranslated regions of actin mRNAs, DNA sequence of a human betaactin cDNA
28. Representative cDNA libraries and their utility in gene expression profiling
29. A high throughput screening for rarely transcribed differentially expressed genes
30. Gapped BLAST and PSIBLAST, a new generation of protein database search programs
31. Identification of a novel protein phosphatase A regulatory subunit highly expressed in muscle
32. Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5′ promoter region of the caveolin-1 gene in human breast cancer cell lines
33. T-cell recognition of self peptides as tumour rejection antigens
34. Statistical aspects of the analysis of data from retrospective studies of disease
35. Flicking the switches: Phosphorylation of serine/threonine protein phosphatases
36. Regulation of protein kinase cascades by protein phosphatase 2A
37. Cell cycle-regulated proteolysis of mitotic target proteins
38. Protein phosphatase 2A: Who shall regulate the regulator?
39. The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR
40. Protein serine/threonine phosphatases, structure, regulation and functions in cell growth
41. Regulation of gene expression by serine/threonine protein phosphatases
42. On target with a new mechanism for the regulation of protein phosphorylation
43. Identification of a new family of protein phosphatase 2A regulatory subunits
44. Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2-p12
45. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation
46. Focal adhesions, contractility, and signaling
47. Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells
48. PKR, a sentinel kinase for cellular stress
49. Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases
50. Reversible protein phosphorylation modulates nucleotide excision repair of damaged DNA by human cell extracts
51. Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
52. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer
53. Alterations of the PPP2R1B gene in human lung and colon cancer