Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage

Cancer Research

Volumn 59, Issue 17, 1999, Pages 4291-4296

  McMenamin, Máirín E ^a   Soung, Peggy ^c   Perera, Sauni ^c   Kaplan, Irving ^a   Loda, Massimo ^b,c   Sellers, William R ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; POLYCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; CANCER CELL; CELL CYCLE; CHROMOSOME 10Q; GENE EXPRESSION; GENE MAPPING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT CANCER; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

EID: 0033200172     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
2. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 275: 1943-1947, 1997.
3. Li, D. M., and Sun, H. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res., 57: 2124-2129, 1997.
4. Myers, M. P., Stolarov, J., End, C., Li, J., Wang, S. I., Wigler, M. H., et al. PTEN, the tumor supressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA, 94: 9052-9057, 1997.
5. Furnari, F. B., Lin, H., Huang, H. S., and Cavenee, W. K. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl. Acad. Sci. USA, 94: 12479-12484, 1997.
6. Cheney, I. W., Johnson, D. E., Vaillancourt, M. T., Avanzini, J., Morimoto, A., Demers, G. W., et al. Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res., 58: 2331-2334, 1998.
7. Di Cristafano, A., Pesce, B., Cordon-Cardo, C., and Pandolfi, P. P. PTEN is essential for embryonic development and tumor suppression. Nat. Genet., 19: 348-355, 1998.
8. Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R., and Yamada, K. M. Inhibition of cell migration, spreading, and focal adhesion by tumor suppressor PTEN. Science (Washington DC), 280: 1614-1617, 1998.
9. Gu, J., Tamura, M., and Yamada, K. M. Tumor suppressor PTEN inhibits integrin-and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J. Cell Biol., 143: 1375-1383, 1998.
10. Maehama, T., and Dixon, J. E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate. J. Biol. Chem., 273: 13375-13378, 1998.
11. 1 growth arrest in glioma cells. Cancer Res., 58: 5002-5008, 1998.
12. 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA, 96:2110-2115, 1999.
13. 1 cell cycle arrest in human glioblastoma cells. Proc. Natl. Acad. Sci. USA, 95: 15406-15411, 1998.
14. Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 95: 29-39, 1998.
15. Wu, X., Senechal, K., Neshat, M. S., Whang, Y. E., and Sawyers, C. L. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA, 95: 15587-15591, 1998.
16. Myers, M. P., Pass, I., Batty, I. H., Van der Kaay, J., Stolarov, J. P., Hemmings, B. A., et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl. Acad. Sci. USA, 95: 13513-13518, 1998.
17. Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., et al. The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/ protein kinase B oncogene. Cancer Res., 58: 5667-5672, 1998.
18. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
19. Nelen, M. R., van Staveren, W. C., Peeters, E. A., Hassel, M. B., Gorlin, R. J., Hamm, H., et al. Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease. Hum. Mol. Genet., 6: 1383-1387, 1997.
20. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons, R., Gorlin, R. J., et al. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16: 333-334, 1997.
21. Chi, S.O., Kim, H. J., Park, B. J., Min, H. J., Park, J. H., Kim, Y. W., et al. Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease. Gastroenterology, 115: 1084-1089, 1998.
22. Wang, S. I., Puc, J., Li, J., Bruce, J. N., Cairns, P., Sidransky, D., et al. Somatic mutations of PTEN in glioblastoma multiforme, Cancer Res., 57: 4183-4186, 1997.
23. Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., et al. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res., 57: 4187-4190, 1997.
24. Liu, W., James, C. D., Frederick, L., Alderete, B. E., and Jenkins, R. B. PTEN/ MMAC1 mutations and EGFR amplification in glioblastomas. Cancer Res., 57: 5254-5257, 1997.
25. Duerr, E. M., Rollbrocker, B., Hayashi, Y., Peters, N., Meyer-Puttlitz, B., Louis, D. N., et al. PTEN mutations in gliomas and glioneuronal tumors. Oncogene, 16: 2259-2264, 1998.
26. Guldberg, P., thor Strafen, P., Birck, A., Ahrenkiel, V., Kirkin, A. F., and Zeuthen, J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res., 57: 3660-3663, 1997.
27. Tsao, H., Zhang, X., Benoit, E., and Haluska, F. G. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene, 16: 3397-3402, 1998.
28. Dahia, P. L., Marsh, D. J., Zheng, Z., Zedenius, J., Komminoth, P., Frisk, T., et al. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res., 57: 4710-4713, 1997.
29. Risinger, J. I., Hayes, A. K., Berchuck, A., and Barrett, J. C. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res., 57: 4736-4738, 1997.
30. Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res., 57: 3935-3940, 1997.
31. Rhei, E., Kang, L., Bogomolniy, F., Federici, M. G., Borgen, P. I., and Boyd, J. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res., 57: 3657-3659, 1997.
32. Cairns, P., Evron, E., Okami, K., Halachmi, N., Esteller, M., Herman, J. G., et al. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene, 16: 3215-3218, 1998.
33. Henderson, Y. C., Wang, E., and Clayman, G. L. Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas. Laryngoscope, 108: 1553-1556, 1998.
34. Whang, Y. E., Wu, X., Suzuki, H., Reiter, R. E., Tran, C., Vessella, R. L., et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl. Acad. Sci. USA, 95: 5246-5250, 1998.
35. Maxwell, G. L., Risinger, J. I., Gumbs, C., Shaw, H., Bentley, R. C., Barrett, J. C., et al. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Res., 58: 2500-2503, 1998.
36. Parker, S. L., Tong, T., Bolden, S., and Wingo, P. A. Cancer statistics, 1997. CA Cancer J. Clin., 47: 5-27, 1997.
37. Gray, I. C., Phillips, S. M., Lee, S. J., Neoptolemos, J. P., Weissenbach, J., and Spurr, N. K. Loss of the chromosomal region 10q23-25 in prostate cancer. Cancer Res., 55: 4800-4803, 1995.
38. Komiya, A., Suzuki, H., Ueda, T., Yatani, R., Emi, M., Ito, H., et al. Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer. Genes Chromosomes Cancer, 17: 245-253, 1996.
39. Teng, D. H., Hu, R., Lin, H., Davis, T., Iliev, D., Frye, C., et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res., 57: 5221-5225, 1997.
40. Cairns, P., Okami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J. G., et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res., 57: 4997-5000, 1997.
41. Wang, S. I., Parsons, R., and Ittmann, M. Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas. Clin. Cancer Res., 4: 811-815, 1998.
42. Pesche, S., Latil, A., Muzeau, F., Cussenot, O., Fournier, G., Longy, M., et al. PTEN/MMAC1/TEP1 involvement in primary prostate cancers. Oncogene, 16: 2879-2883, 1998.
43. Suzuki, H., Freije, D., Nusskern, D. R., Okami, K., Cairns, P., Sidransky, D., et al. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res., 58: 204-209, 1998.
44. Vlietstra, R. J., van Alewijk, D. C., Hermans, K. G., van Steenbrugge, G. J., and Trapman, J. Frequent inactivation of PTEN in prostate cancer cell lines and xenografts. Cancer Res., 58: 2720-2723, 1998.
45. Gray, I. C., Stewart, L. M., Phillips, S. M., Hamilton, J. A., Gray, N. E., Watson, G. J., et al. Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN. Br. J. Cancer, 78: 1296-1300, 1998.
46. Loda, M., Capodieci, P., Mishra, R., Yao, H., Corless, C., Grigioni, W., et al. Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis. Am. J. Pathol., 149: 1553-1564, 1996.
47. Magi-Galluzzi, C., Mishra, R., Fiorentino, M., Montironi, R., Yao, H., Capodieci, P., et al. Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. Lab. Invest., 76: 37-51, 1997.
48. Magi-Galluzzi, C., Montironi, R., Cangi, M. G., Wishnow, K., and Loda, M. Mitogen-activated protein kinases and apoptosis in PIN. Virchows Arch., 432: 407-413, 1998.
49. Magi-Galluzzi, C., Xu, X., Hlatky, L., Hahnfeldt, P., Kaplan, I., Hsiao, P., et al. Heterogeneity of androgen receptor content in advanced prostate cancer. Mod. Pathol., 10: 839-845, 1997.
50. Fleming, I. D., Cooper, J. S., Henson, D. E., Hutter, R. V. P., Kennedy, B. J., Murphy, G. P., O'Sullivan, B., Sobin, Z. H., and Yarbro, J. W. (eds). American Joint Committee on Cancer. Manual for Staging of Cancer, 5th ed., pp. 220-224, Philadelphia: Lippincott, 1997.
51. Iliopoulos, O., Kibel, A., Gray, S., and Kaelin, W. G., Jr. Tumour suppression by the human von Hippel-Lindau gene product. Nat. Med., 1: 822-826, 1995.
52. Harlow, E., and Lane, D. Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1988.
53. Bostwick, D. Prospective origins of prostate carcinoma. Prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia. Cancer (Phila.), 78: 330-336, 1996.
54. Sano, T., Lin, H., Chen, X., Langford, L. A., Koul, D., Bondy, M. L., et al. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res., 59: 1820-1824, 1999.
55. Gleason, D. F. Histologic grading of prostate cancer: a perspective. Hum. Pathol., 23: 273-279, 1992.
56. Suzuki, A., de la Pompa, J. L, Stambolic, V., Elia, A. J., Sasaki, T., del Banco Barrantes, I., et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol., 8: 1169-1178, 1998.
57. Nefsky, B., and Beach, D. Publ acts as an E6-AP-like protein ubiquitin ligase in the degradation of cdc25. EMBO J., 15: 1301-1312, 1996.
58. Davies, M. A., Lu, Y., Sano, T., Fang, X., Tang, P., LaPushin, R., et al. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res., 58: 5285-5290, 1998.
59. Haas-Kogan, D., Shalev, N., Wong, M., Mills, G., Yount, G., and Stokoe, D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr. Biol., 8: 1195-1198, 1998.