Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Biochemical Journal

Volumn 353, Issue 3, 2001, Pages 417-439

  Janssens, V ^a   Goris, J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cell cycle; Dephosphorylation; Methylation; PP2A; Tumour suppressor

Indexed keywords

DNA; INHIBITOR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN KINASE; TAU PROTEIN; VIRUS PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; CELL MATURATION; CELL STRUCTURE; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; DEPHOSPHORYLATION; DNA DAMAGE; DNA REPLICATION; DROSOPHILA; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; KNOCKOUT MOUSE; METHYLATION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; RNA TRANSLATION; SECOND MESSENGER; SIGNAL TRANSDUCTION; YEAST;

ANIMALS; CELL DIVISION; PHOSPHOPROTEIN PHOSPHATASE; SIGNAL TRANSDUCTION;

EID: 0035252894     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3530417     Document Type: Review

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82. An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A
83. A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
84. Okadaic acid and microcystin-LR directly inhibit the methylation of protein phosphatase 2A by its specific methyltransferase
85. Carboxyl methylation of protein phosphatase 2A from Xenopus eggs is stimulated by cAMP and inhibited by okadaic acid
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87. Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression
88. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue
89. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
90. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo
91. 0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells
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93. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit
94. Carboxy-methylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits, Cdc55p and Rts1p
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96. Signal transduction of stress via ceramide
97. Ceramide stimulates a cytosolic protein phosphatase
98. Ceramide activates heterotrimeric protein phosphatase 2A
99. 2-ceramide
100. Purification and characterization of ceramide-activated protein phosphatases
101. 1 arrest of Saccharomyces cerevisiae
102. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
103. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
104. c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells
105. Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney
106. PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity
107. PP2A, associate with and modify the substrate specificity of protein phosphatase 1
108. PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A
109. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A
110. Functional domains of template-activating factor-I as a protein phosphatase 2A inhibitor
111. Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia
112. CAN, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: Characterization of the SET gene
113. HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A
114. Down-regulation by retinoic acid of the catalytic subunit of protein phosphatase type 2A during granulocytic differentiation of HL-60 cells
115. Expression of the catalytic and regulatory subunits of protein phosphatase type 2A may be differentially modulated during retinoic acid-induced granulocytic differentiation of HL-60 cells
116. PPARγ induces cell cycle withdrawal: Inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
117. Protein phosphatase 2A is expressed in response to colony-stimulating factor 1 in macrophages and is required for cell cycle progression independently of extracellular signal-regulated protein kinase activity
118. Characterization of a phosphotyrosyl protein phosphatase activity associated with a phosphoseryl protein phosphatase of Mr = 95,000 from bovine heart
119. Isolation and characterization of rabbit skeletal muscle protein phosphatases C-I and C-II
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126. Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A
127. PTPA adjusts the phosphotyrosyl phosphatase activity of PP2A
128. A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn
129. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A
130. Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene
131. Functional analysis of the promoter region of the human phosphotyrosine phosphatase activator gene: Yin Yang 1 is essential for core promoter activity
132. The phosphotyrosyl phosphatase activator gene is a novel p53 target gene
133. The Saccharomyces cerevisiae homologue YPA1 of the mammalian phosphotyrosyl phosphatase activator of protein phosphatase 2A controls progression through the G1 phase of the yeast cell cycle
134. Functional analysis of RRD1 (YIL153w) and RRD2 (YIL152w), which encode two putative activators of the phosphotyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae
135. The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations
136. A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-oxide
137. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases
138. Okadaic acid: A new probe for the study of cellular regulation
139. PPX, a novel protein serine/threonine phosphatase localized to centrosomes
140. Purification of protein phosphatase 4 catalytic subunit: Inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters
141. A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus
142. Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
143. Okadaic acid, a non-TPA tumor promotor, inhibits specifically protein phosphatases, induces maturation and MPF formation in Xenopus laevis oocytes
144. Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases
145. Characterization of the PP2Aα gene mutation in okadaic acid-resistant variants of CHO-K1 cells
146. PTPA, a novel phosphotyrosyl phosphatase activator of the polycation-stimulated protein phosphatases
147. Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
148. A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity
149. Okadaic acid: An additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter
150. Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds
151. 2+ deficiency
152. Highly frequent single amino acid substitution in mammalian elongation tactor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins
153. Okadaic acid, a protein phosphatase inhibitor, induces sister-chromatid exchanges depending on the presence of bromodeoxyuridine
154. Protein serine/threonine phosphatases as binding proteins for okadaic acid
155. Okadaic acid and phorbol esters: Comparative effects of these tumor promoters on cell transformation, intercellular communication and differentiation in vitro
156. Okadaic acid: A reversible inhibitor of neoplastic transformation of mouse fibroblasts
157. v-src-induced transformation is inhibited by okadaic acid
158. Okadaic acid inhibits PDGF-induced proliferation and decreases PDGF receptor number in C3H/10T1/2 mouse fibroblasts
159. Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A
160. Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity
161. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases
162. Tautomycin from the bacterium Streptomyces verticillatus. Another potent and specific inhibitor of protein phosphatases 1 and 2A
163. Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases
164. Cantharidin binding protein: Identification as protein phosphatase 2A
165. The decision to enter mitosis
166. Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes
167. Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish
168. Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase
169. Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: Evidence from the effects of okadaic acid
170. Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells
171. INH, a negative regulator of MPF, is a form of protein phosphatase 2A
172. Inhibition of cdc2 activation by INH/PP2A
173. cdc2 function
174. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2
175. cdc2 on Thr-14 and Tyr-15 at the prophase/metaphase transition
176. MPF amplification in Xenopus oocyte extracts depends on a two-step activation of Cdc25 phosphatase
177. Phosphatase 2A and Polo kinase, two antagonistic regulators of Cdc25 activation and MPF auto-amplification
178. Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts
179. Inhibition of mitosis by okadaic acid: Possible involvement of a protein phosphatase 2A in the transition from metaphase to anaphase
180. Cell cycle-regulated proteolysis of mitotic target proteins
181. 1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases
182. The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130
183. Constant expression and activity of protein phosphatase 2A in synchronized cells
184. A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
185. Yeast protein serine/threonine phosphatases: Multiple roles and diverse regulation
186. Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms
187. Functional expression of human and Arabidopsis protein phosphatase 2A in Saccharomyces cerevisiae and isolation of dominant-defective mutants
188. Important role for phylogenetically invariant PP2Acα active site and C-terminal residues revealed by mutational analysis in Saccharomyces cerevisiae
189. Protein phosphatase 2A in Saccharomyces cerevisiae: Effects on cell growth and bud morphogenesis
190. The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis
191. Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis
192. A general screen for mutants of Saccharomyces cerevisiae deficient in tRNA biosynthesis
193. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisae
194. The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis
195. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
196. Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae
197. Rox3 and Rts1 function in the global stress response pathway in baker's yeast
198. SCS1, a multicopy suppressor of hsp60-ts mutant alleles, does not encode a mitochondrially targeted protein
199. Molecular genetic analysis of Rts1p, a B′ regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A
200. Saccharomyces cerevisiae homologs of mammalian B and B′ subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions
201. +: Two Schizosaccharomyces pombe genes encoding B′ subunits of protein phosphatase 2A
202. Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila
203. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase
204. Phosphorylation status of the SCR homeodomain determines its functional activity: Essential role for protein phosphatase 2A, B′
205. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos
206. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila
207. Abnormal anaphase resolution (aar): A locus required for progression through mitosis in Drosophila
208. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs
209. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
210. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint
211. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα
212. Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development
213. Identification of a domain of axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
214. Regulation of beta-catenin signaling in the Wnt pathway
215. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A
216. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK-3β
217. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
218. GSK-3β-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by β-catenin and protein phosphatase 2A complexed with axin
219. A positive role for the PP2A catalytic subunit in Wnt signal transduction
220. The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40
221. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
222. Polyoma virus transforming protein associates with the product of the c-src cellular gene
223. Association of the polyomavirus middle-T antigen with c-yes protein
224. c-fyn is capable of complex formation with the middle-T antigen of polyomavirus
225. c-src: A possible phosphatidylinositol kinase
226. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
227. Association of protein phosphatase 2A with polyoma virus medium tumor antigen
228. Control of protein phosphatase 2A by simian virus 40 small-t antigen
229. Identification of structural elements involved in the interaction of Simian Virus 40 small tumor antigen with protein phosphatase 2A
230. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation
231. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens
232. Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase
233. Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase
234. c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation
235. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A
236. Association between src-kinases and the polyoma virus oncogene middle T-antigen requires PP2A and a specific sequence motif
237. c-src
238. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity
239. Protein phosphatase 2A is a critical regulator of protein kinase C ζ signaling targeted by SV40 small t to promote cell growth and NF-κB activation
240. Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
241. Induction of cyclin D1 by simian virus 40 small tumor antigen
242. Protein phosphatase 2A and phosphatidylinositol 3-kinase regulate the activity of Sp1-responsive promoters
243. Signaling from polyomavirus middle T and small T defines different roles for protein phosphatase 2A
244. Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production
245. 0 by HIV-1 encoded protein complex NCp7:vpr
246. Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A
247. Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription
248. Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A
249. Adenovirus E4orf4 protein interacts with both Bα and B′ subunits of protein phosphatase 2A, but E4orf4-induced apoptosis is mediated only by the interaction with Bα
250. Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Bα subunit of protein phosphatase 2A
251. Reduction of HA-ras-induced cellular transformation by elevated expression of protein phosphatase type 2A
252. Structure and function of simian virus 40 large tumor antigen
253. Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro
254. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A
255. Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity
256. Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: Inhibition by small-t antigen
257. Protein phosphatase 2A is required for the initiation of chromosomal DNA replication
258. The interrelationship between cAMP-dependent α and β subunit phosphorylation in the regulation of phosphorylase kinase activity: Studies using subunit specific phosphatases
259. Regulation of protein kinase cascades by protein phosphatase 2A
260. Dephosphorylation of catalytic subunit of cAMP-dependent protein kinase at Thr-197 by a cellular protein phosphatase and by purified protein phosphatase-2A
261. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
262. Inactivation and dephosphorylation of protein kinase Bα (PKBα) promoted by hyperosmotic stress
263. Regulation of recombinant PKC alpha activity by protein phosphatase 1 and protein phosphatase 2A
264. 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Cα correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer
265. In vivo activation of a microtubule-associated protein kinase during meiotic maturation of the Xenopus oocyte
266. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
267. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
268. Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells
269. Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-κB activation
270. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
271. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
272. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
273. Regulation of protein phosphatase 2A by direct interaction with casein kinase 2α
274. CK2α-protein phosphatase 2A molecular complex: Possible interaction with the MAP kinase pathway
275. 2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A
276. Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A
277. Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
278. Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells
279. Complex formation of JAK2 with PP2A, PI3K, and Yes in response to the hematopoietic cytokine interleukin-11
280. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
281. v1.2) and antagonizes channel phosphorylation by cAMP-dependent protein kinase
282. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the Golgi apparatus
283. Raf-1-associated PP2A as a positive regulator of kinase activation
284. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
285. Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate
286. Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction
287. B cell receptor-associated protein α4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
288. Ig receptor binding protein 1 (α4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A
289. TOR signalling and control of cell growth
290. Regulation of protein phosphatase 2A catalytic activity by alpha4 protein and its yeast homolog Tap42
291. Alpha 4 associates with protein phosphatases 2A, 4 and 6
292. Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases
293. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
294. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the α4 subunit which promotes dephosphorylation of elongation factor-2
295. A new member of the α4-related molecule (α4-b) that binds to the protein phosphatase 2A is expressed selectively in the brain and testis
296. The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1
297. A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor
298. The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae
299. The end in sight: Terminating translation in eukaryotes
300. Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3
301. Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis
302. Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A
303. Regulation of protein phosphatase 2A activity by heat shock transcription factor 2
304. Molecular basis of competition between HSF2 and catalytic subunit for binding to the PR65/A subunit of PP2A
305. Dephosphorylation of the small heat shock protein Hsp27 in vivo by protein phosphatase 2A
306. p53-dependent association between cyclin G and the B′ subunit of protein phosphatase 2A
307. Cyclin G is a transcriptional target of the p53 tumor suppressor protein
308. Cyclin G contributes to G2/M arrest of cells in response to DNA damage
309. A role of cyclin G in the process of apoptosis
310. Developmental expression and co-localization of cyclin G1 and the B′ subunits of protein phosphatase 2A in neurons
311. A question of life or death: The p53 tumor suppressor gene
312. Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
313. The effect of phosphorylation on the antigenic reactivity of p53 in cultured human keratinocytes
314. Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter
315. Hyperphosphorylation of p53 induced by okadaic acid attenuates its transcriptional activation function
316. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
317. Specific enzymatic dephosphorylation of the retinoblastoma protein
318. Characterization of the mitotic phase pRB-directed protein phosphatase activity
319. Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells
320. Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2A regulates the activities of G1 cyclin-dependent kinases
321. Rapid dephosphorylation of p107 following UV irradiation
322. Brain protein serine/threonine phosphatases
323. Neurofilament-associated protein phosphatase 2A: Its possible role in preserving neurofilaments in filamentous states
324. Protein serine/threonine phosphatase 1 and 2A associate with and dephosphorylate neurofilaments
325. Tau domains, phosphorylation, and interactions with microtubules
326. Disruption of the cytoskeleton in Alzheimer's disease
327. Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
328. An anchoring factor targets protein phosphatase 2A to brain microtubules
329. 1
330. Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A
331. Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease helical filament tau
332. The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases
333. In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons
334. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease
335. Regulation of the phosphorylation state and microtubule-binding activity of tau by protein phosphatase 2A
336. Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons (NT2N cells)
337. Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies
338. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A
339. Identification by differential display of a protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells
340. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation
341. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells