Loss of heterozygosity and microsatellite instability at chromosomal sites 1Q and 10Q in morphologically distinct regions of late stage prostate lesions

Journal of Urology

Volumn 166, Issue 5, 2001, Pages 1931-1936

  Latini, Jerilyn M ^a   Rieger Christ, Kimberly M ^a   Wang, David S ^a   Silverman, Mark L ^a   Libertino, John A ^a   Summerhayes, Ian C ^a  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Adenocarcinoma; Loss of heterozygosity; Microsatellite repeats; Prostate; Prostatic neoplasms

Indexed keywords

ADVANCED CANCER; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 1Q; CONTROLLED STUDY; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROSTATE HYPERTROPHY; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

EID: 0034796233     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)65723-0     Document Type: Article

References (45)

1. Genetic pattern of prostate cancer progression
2. Allelic loss on chromosome 6Q in primary prostate cancer
3. Prognostic significance of allelic imbalance of chromosome arms 7q, 8p, 16q, and 18q in stage T3N0M0 prostate cancer
4. A molecular cytogenetic analysis of 7q31 in prostate cancer
5. Homozygous and frequent deletion of proximal 8p sequences in human prostate cancers: Identification of a potential tumor suppressor gene site
6. Loss of two new loci on chromosome 8 (8p23 and 8q12-13) in human prostate cancer
7. High frequency of deletion on chromosome 9p21 may harbor several tumor-suppressor genes in human prostate cancer
8. Loss of the chromosomal region 10q23-25 in prostate cancer
9. Microsatellite instability and deletion analysis of chromosome 10 in human prostate cancer
10. Deletion mapping at 12p 12-13 in metastatic prostate cancer
11. Identification of 12p as a region of frequent deletion in advanced prostate cancer
12. Loss of heterozygosity on chromosome 13 is associated with advanced stage prostate cancer
13. Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer
14. Three independently deleted regions at chromosome arm 16q in human prosrate cancer: Allelic loss at 16q24.1-q24.2 is associated with aggressive behavior of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient
15. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostate tumorigenesis
16. p53 protein accumulation and gene mutation in the progression of human prostate carcinoma
17. Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer
18. Mutation of the MXI1 gene in prostate cancer
19. Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11
20. Mutational analysis of CDKN2 (CDK4I/MTS1) gene in tissues and cell lines of human prostate cancer
21. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
22. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
23. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
24. PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate
25. Analysis of PTEN and the 10q23 region in primary prostate carcinomas
26. Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma
27. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
28. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
29. Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search
30. Predisposing gene for early-onset prostate cancer, localized on chromosome 1q42.2-43
31. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
32. Evidence for a prostate cancer susceptibility locus on the X chromosome. Group 5
33. Prostate cancer susceptibility locus on chromosome 1q: A confirmatory study
34. Allelic imbalance in familial and sporadic prostate cancer at the putative human prostate cancer susceptibility locus, HPC1
35. Precise microdissection of human prostate reveals genotypic heterogeneity
36. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
37. Somatic mutation of PTEN in vulvar cancer
38. High frequency of mutator phenotype in human prostatic adenocarcinoma
39. Microsatellite instability in human prostate cancer
40. Microsatellite instability in prostate cancer
41. High frequency of genetic instability of microsatellites in human prostatic adenocarcinoma
42. Microsatellite instability in adenocarcinoma of the prostate
43. Allelic imbalance and microsatellite instability in prostatic adenocarcinoma
44. Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21
45. Genomic instability of microsatellite repeats in prostate cancer: Relationship to clinicopathological variables