Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

Cancer Cell

Volumn 1, Issue 3, 2002, Pages 257-267

  Chan, Joanne ^a,b   Bayliss, Peter E ^a,b   Wood, Jeanette M ^c   Roberts, Thomas M ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; VASCULOTROPIN INHIBITOR; VATALANIB; ANGIOGENESIS INHIBITOR; COMPLEMENTARY DNA; ENZYME INHIBITOR; GROWTH FACTOR RECEPTOR; ONCOPROTEIN; PHTHALAZINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE; RNA; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLOOD FLOW; BLOOD VESSEL; CHEMICAL GENETICS; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PRIORITY JOURNAL; ZEBRA FISH; AMINO ACID SEQUENCE; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; IN SITU HYBRIDIZATION; METABOLISM; MOLECULAR GENETICS; NICK END LABELING; PHYSIOLOGY; PRENATAL DEVELOPMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

DANIO RERIO;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANIMALS; DNA, COMPLEMENTARY; EMBRYO; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; PHTHALAZINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; UP-REGULATION; ZEBRAFISH;

EID: 0036527350     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00042-9     Document Type: Article

References (58)

1. Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A.F., Stemple, D.L., Malicki, J., Neuhauss, S.C., Zwartkruis, F., Stainier, D.Y., et al. (1996). Mutations affecting neural survival in the zebrafish Danio rerio. Development 123, 217-227.
2. Argenton, F., Zecchin, E., and Bortolussi, M. (1999). Early appearance of pancreatic hormone-expressing cells in the zebrafish embryo. Mech. Dev. 87, 217-221.
3. Biemar, F., Argenton, F., Schmidtke, R., Epperlein, S., Peers, B., and Driever, W. (2001). Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev. Biol. 230, 189-203.
4. Bold, G., Altmann, K.H., Frei, J., Lang, M., Manley, P.W., Traxler, P., Wietfeld, B., Bruggen, J., Buchdunger, E., Cozens, R., et al. (2000). New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. J. Med. Chem. 43, 2310-2323.
5. Carmeliet, P. (2000). Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6, 389-395.
6. Carmeliet, P., and Jain, R.K. (2000). Angiogenesis in cancer and other diseases. Nature 407, 249-257.
7. Chan, J., and Watt, V.M. (1991). eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. Oncogene 6, 1057-1061.
8. Chan, J., Mably, J.D., Serluca, F.C., Chen, J.N., Goldstein, N.B., Thomas, M.C., Cleary, J.A., Brennan, C., Fishman, M.C., and Roberts, T.M. (2001). Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. Dev. Biol. 234, 470-482.
9. Chen, J.N., van Bebber, F., Goldstein, A.M., Serluca, F.C., Jackson, D., Childs, S., Serbedzija, G., Warren, K.S., Mably, J.D., Lindahl, P., et al. (2001). Genetic steps to organ laterality in zebrafish. Comp. Funct. Genom. 2, 60-68.
10. Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., and Zeiher, A.M. (1999). Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399, 601-605.
11. Drevs, J., Hofmann, I., Hugenschmidt, H., Wittig, C., Madjar, H., Muller, M., Wood, J., Martiny-Baron, G., Unger, C., and Marme, D. (2000). Effects of PTK787/ZK222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res. 60, 4819-4824.
12. Ekker, S.C. (2000). Morphants: a new systematic vertebrate functional genomics approach. Yeast 17, 302-306.
13. Favata, M.F., Horiuchi, K.Y., Manos, E.J., Daulerio, A.J., Stradley, D.A., Feeser, W.S., Van Dyk, D.E., Pitts, W.J., Earl, R.A., Hobbs, F., et al. (1998). Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273, 18623-18632.
14. Ferrara, N., and Alitalo, K. (1999). Clinical applications of angiogenic growth factors and their inhibitors. Nat. Med. 5, 1359-1364.
15. Fishman, M.C. (2001). Genomics. Zebrafish - the canonical vertebrate. Science 294, 1290-1291.
16. Fouquet, B., Weinstein, B.M., Serluca, F.C., and Fishman, M.C. (1997). Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev. Biol. 183, 37-48.
17. Fujio, Y., and Walsh, K. (1999). Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J. Biol. Chem. 274, 16349-16354.
18. Fulton, D., Gratton, J.P., McCabe, T.J., Fontana, J., Fujio, Y., Walsh, K., Franke, T.F., Papapetropoulos, A., and Sessa, W.C. (1999). Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399, 597-601.
19. Gerber, H.P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B.A., Dixit, V., and Ferrara, N. (1998). Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273, 30336-30343.
20. Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M., Mbamalu, G., Pawson, T., Jan, Y., Stainier, D.Y., and Abdelilah-Seyfried, S. (2001). Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr. Biol. 11, 1492-1502.
21. Isogai, S., Horiguchi, M., and Weinstein, B.M. (2001). The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Dev. Biol. 230, 278-301.
22. Jiang, B.H., Zheng, J.Z., Aoki, M., and Vogt, P.K. (2000). Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. USA 97, 1749-1753.
23. Kimmel, C.B., Ballard, W.W., Kimmel, S.R., Ullmann, B., and Schilling, T.F. (1995). Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253-310.
24. Lammert, E., Cleaver, O., and Melton, D. (2001). Induction of pancreatic differentiation by signals from blood vessels. Science 294, 564-567.
25. Lewandoski, M. (2001). Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2, 743-755.
26. Liang, D., Xu, X., Chin, A.J., Balasubramaniyan, N.V., Teo, M.A., Lam, T.J., Weinberg, E.S., and Ge, R. (1998). Cloning and characterization of vascular endothelial growth factor (VEGF) from zebrafish, Danio rerio. Biochim. Biophys. Acta 1397, 14-20.
27. Liao, W., Bisgrove, B.W., Sawyer, H., Hug, B., Bell, B., Peters, K., Grunwald, D.J., and Stainier, D.Y. (1997). The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development 124, 381-389.
28. MacNicol, A.M., Muslin, A.J., and Williams, L.T. (1993). Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF. Cell 73, 571-583.
29. Matsumoto, K., Yoshitomi, H., Rossant, J., and Zaret, K.S. (2001). Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294, 559-563.
30. Meyer, T., Regenass, U., Fabbro, D., Alteri, E., Rosel, J., Muller, M., Caravatti, G., and Matter, A. (1989). A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity. Int. J. Cancer 43, 851-856.
31. Milewski, W.M., Duguay, S.J., Chan, S.J., and Steiner, D.F. (1998). Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology 139, 1440-1449.
32. Mills, A.A. (2001). Changing colors in mice: an inducible system that delivers. Genes Dev. 15, 1461-1467.
33. Morales-Ruiz, M., Fulton, D., Sowa, G., Languino, L.R., Fujio, Y., Walsh, K., and Sessa, W.C. (2000). Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ. Res. 86, 892-896.
34. Nasevicius, A., and Ekker, S.C. (2000). Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220.
35. Nasevicius, A., Larson, J., and Ekker, S.C. (2000). Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. Yeast 17, 294-301.
36. Ozaki, H., Seo, M.S., Ozaki, K., Yamada, H., Yamada, E., Okamoto, N., Hofmann, F., Wood, J.M., and Campochiaro, P.A. (2000). Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am. J. Pathol. 156, 697-707.
37. Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999). Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development 126, 3425-3436.
38. Peterson, R.T., Link, B.A., Dowling, J.E., and Schreiber, S.L. (2000). Small molecule developmental screens reveal the logic and timing of vertebrate development. Proc. Natl. Acad. Sci. USA 97, 12965-12969.
39. Peterson, R.T., Mably, J.D., Chen, J.N., and Fishman, M.C. (2001). Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr. Biol. 11, 1481-1491.
40. Ramaswamy, S., Nakamura, N., Vazquez, F., Batt, D.B., Perera, S., Roberts, T.M., and Sellers, W.R. (1999). Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA 96, 2110-2115.
41. Roy, S., Qiao, T., Wolff, C., and Ingham, P.W. (2001). Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Curr. Biol. 11, 1358-1363.
42. Rubin, G.M. (1991). Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet. 7, 372-377.
43. Serluca, F.C., and Fishman, M.C. (2001). Pre-pattern in the pronephric kidney field of zebrafish. Development 128, 2233-2241.
44. Serluca, F.C., Drummond, I.A., and Fishman, M.C. (2002) Endothelial signaling in kidney morphogenesis: A role for hemodynamic forces. Curr. Biol. 12, 492-497.
45. Simon, M.A., Bowtell, D.D., Dodson, G.S., Laverty, T.R., and Rubin, G.M. (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67, 701-716.
46. Smith, E.A., Seldin, M.F., Martinez, L., Watson, M.L., Choudhury, G.G., Lalley, P.A., Pierce, J., Aaronson, S., Barker, J., Naylor, S.L., et al. (1991). Mouse platelet-derived growth factor receptor alpha gene is deleted in W19H and patch mutations on chromosome 5. Proc. Natl. Acad. Sci. USA 88, 4811-4815.
47. Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., et al. (1996). Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123, 285-292.
48. Stephenson, D.A., Mercola, M., Anderson, E., Wang, C.Y., Stiles, C.D., Bowen-Pope, D.F., and Chapman, V.M. (1991). Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc. Natl. Acad. Sci. USA 88, 6-10.
49. Sternberg, P.W. (1993). Intercellular signaling and signal transduction in C. elegans. Annu. Rev. Genet. 27, 497-521.
50. Sternberg, P.W., and Horvitz, H.R. (1991). Signal transduction during C. elegans vulval induction. Trends Genet. 7, 366-371.
51. Sumoy, L., Keasey, J.B., Dittman, T.D., and Kimelman, D. (1997). A role for notochord in axial vascular development revealed by analysis of phenotype and the expression of VEGR-2 in zebrafish flh and ntl mutant embryos. Mech. Dev. 63, 15-27.
52. Thisse, C., and Zon, L.I. (2002). Organogenesis - heart and blood formation from the zebrafish point of view. Science 295, 457-462.
53. Thompson, M.A., Ransom, D.G., Pratt, S.J., MacLennan, H., Kieran, M.W., Detrich, H.W., 3rd, Vail, B., Huber, T.L., Paw, B., Brownlie, A.J., et al. (1998). The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev. Biol. 197, 248-269.
54. Turner, D.L., and Weintraub, H. (1994). Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8, 1434-1447.
55. Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C. (1995). Grid-lock, a localized heritable vascular patterning defect in the zebrafish. Nat. Med. 1, 1143-1147.
56. Wen, S., Stolarov, J., Myers, M.P., Su, J.D., Wigler, M.H., Tonks, N.K., and Durden, D.L. (2001). PTEN controls tumor-induced angiogenesis. Proc. Natl. Acad. Sci. USA 98, 4622-4627.
57. Westerfield, M. (1995). The Zebrafish Book: Guide for the Laboratory Use of Zebrafish (Danio rerio). (Eugene, Oregon: University of Oregon Press).
58. Wood, J.M., Bold, G., Buchdunger, E., Cozens, R., Ferrari, S., Frei, J., Hofmann, F., Mestan, J., Mett, H., O'Reilly, T., et al. (2000). PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60, 2178-2189.