Presenilin-1 and -2 are molecular targets for γ-secretase inhibitors

Journal of Biological Chemistry

Volumn 275, Issue 44, 2000, Pages 34086-34091

  Seiffert, Dietmar ^a   Bradley, Jodi D ^a   Rominger, Cynthia M ^a   Rominger, David H ^a   Yang, Fude ^a   Meredith Jr , Jere E ^a   Wang, Qian ^a   Roach, Arthur H ^a   Thompson, Lorin A ^a   Spitz, Susan M ^a   Higaki, Jeffrey N ^b   Prakash, Shimoga R ^a   Combs, Andrew P ^a   Copeland, Robert A ^a   Arneric, Stephen P ^a   Hartig, Paul R ^a   Robertson, David W ^a   Cordell, Barbara ^b   Stern, Andrew M ^a   Olson, Richard E ^a   Zaczek, Robert ^a   more..

^a DUPONT COMPANY   (United States)

^b Scios   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MEMBRANE PROTEIN; POLYPEPTIDE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME DEGRADATION; FAMILIAL DISEASE; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

EID: 0034602419     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005430200     Document Type: Article

References (24)