Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFκB activation

Laboratory Investigation

Volumn 81, Issue 10, 2001, Pages 1371-1383

  Morel, Jacques C M ^a   Park, Christy C ^a,b   Kumar, Pawan ^a   Koch, Alisa E ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; BETA CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; FIBROBLAST; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; TIME; WESTERN BLOTTING;

EID: 0034769467     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780351     Document Type: Article

References (44)

1. Human chemokines: An update
2. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes
3. A newly defined interleukin-1
4. Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines
5. Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts
6. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
7. IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
8. Interleukin-18 and interleukin-1 beta: Two cytokine substrates for ICE (caspase-1)
9. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
10. A proinflammatory role for IL-18 in rheumatoid arthritis
11. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
12. Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritis
13. Chemokines in arthritis
14. Stimulation of neovascularization by human rheumatoid synovial tissue macrophages
15. An essential role for NF-kappa B in IL-18-induced IFN-gamma expression in KG-1 cells
16. NF-kappa B subunit-specific regulation of the interleukin-8 promoter
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
19. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells
20. Enhanced expression of interleukin-18 in synovial fibroblast-like cells from patient with rheumatoid arthritis and IL-18-receptor expression
21. Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with proinflammatory mediators and dinitrochlorobenzene
22. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
23. Cloning of a new cytokine that induces IFN-gamma production by T cells
24. M IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
25. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells
26. Manipulation of distinct NFkappaB proteins alters interleukin-1beta-induced human rheumatoid synovial fibroblast prostaglandin E2 formation
27. Effects of Th1 and Th2 cytokines on cytokine production and ICAM-1 expression on synovial fibroblasts
28. Characterization of the immunophenotype and functional properties of fibroblast-like synoviocytes in comparison to skin fibroblasts and umbilical vein endothelial cells
29. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
30. Opposite effects of interleukin-13 and interleukin-12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells
31. Interleukin 18 stimulates HIV type 1 in monocytic cells
32. Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-kappa B activation in synovial fibroblasts
33. The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts
34. Pathogenesis and treatment of rheumatoid arthritis: Chemokines in rheumatoid arthritis
35. Defective NK cell activity and Th1 response in IL-18-deficient mice
36. Purification and characterization of the human interleukin-18 receptor
37. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation
38. Oct-1 and CCAAT/enhancer-binding protein (C/EBP) bind to overlapping elements within the interleukin-8 promoter. The role of Oct-1 as a transcriptional repressor
39. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene
40. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells
41. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production
42. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
43. Rhinovirus stimulation of interleukin-8 in vivo and in vitro: Role of NF-kappaB