Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection

Virology

Volumn 287, Issue 1, 2001, Pages 163-170

  Mori, Isamu ^a   Hossain, Md Jaber ^a   Takeda, Kiyoshi ^b   Okamura, Haruki ^c   Imai, Yoshinori ^d   Kohsaka, Shinichi ^d   Kimura, Yoshinobu ^a  

^a University of Fukui   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

Author keywords

Apoptosis; Brain; Iba1; Influenza virus; Interferon ; Interleukin 18; Macrophages; Microglia; Neurodegeneration; Neuron

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 18; RECOMBINANT GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CELL TRANSFORMATION; FEMALE; GENE ACTIVATION; GENE DISRUPTION; INFLUENZA VIRUS A; MACROPHAGE; MICROGLIA; MOUSE; NERVE DEGENERATION; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS PATHOGENESIS;

EID: 0035881917     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.1029     Document Type: Article

References (41)

1. Neuronal IFN-γ in tuberomammillary neurones
2. Cultures of astrocytes and microglia express interleukin 18
3. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
4. Interferon-γ-like immunoreactivity in sensory neurons may influence the replication of Sendai and mumps viruses
5. Type A influenza: Postmortem virus isolations from different organs in human lethal cases
6. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis
7. Interleukin-18 protects mice against acute herpes simplex virus type 1 infection
8. Influenza virus antigen in postencephalitic parkinsonism brain. Detection by immunofluorescence
9. A pregnant woman with influenza A encephalopathy in whom influenza A/Hong Kong virus (H3) was isolated from cerebrospinal fluid
10. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
11. A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage
12. Microglia-specific localisation of a novel calcium binding protein, Iba1
13. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
14. Microglia: A sensor for pathological events in the CNS
15. Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium
16. Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice
17. Upregulated expression of Iba1 molecules in the central nervous system of mice in response to neurovirulent influenza A virus infection
18. Apoptotic neurodegeneration induced by influenza A virus infection in the mouse brain
19. Neuropathogénesis of influenza virus infection in mice
20. Viremia induced by influenza virus
21. The role of tumour necrosis factor, interleukin 6, interferon-γ and inducible nitric oxide synthase in the development and pathology of the nervous system
22. Neurological complications of influenza A2-Hong Kong-68 virus
23. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection
24. Involvement of iba1 in membrane ruffling and phagocytosis of macrophage /microglia
25. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
26. Cloning of a new cytokine that induces IFN-γ production by T cells
27. Intedeukin-18: A novel cytokine that augments both innate and acquired immunity
28. Neuronal interferon-γ immunoreactive molecule: Bioactivities and purification
29. Gamma-interferon-like immunoreactivity in axotomized rat motor neurons
30. Murine microglial cells produce and respond to interleukin-18
31. IFN-γ and IL-12 induce IL-18 receptor gene expression in human NK and T cells
32. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells
33. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
34. Influenza virus-induced encephalopathy: Clinicopathologic study of an autopsied case
35. Defective NK cell activity and Th1 response in IL-18-deficient mice
36. Immunohistochemical and immuno-electron-microscopic detection of interferon-γ-inducing factor ("interleukin-18") in mouse intestinal epithelial cells
37. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection
38. Epidemiology of influenza-associated encephalitis-encephalopathy in Hokkaido, the norchernmost island of Japan
39. IFN-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
40. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
41. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production