Interleukin-18 induces production of proinflammatory cytokines in mice: No intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1β

European Journal of Immunology

Volumn 30, Issue 10, 2000, Pages 3057-3060

  Netea, Mihai G ^a   Kullberg, Bart Jan ^a   Verschueren, Ineke ^a   Van Der Meer, Jos W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

CD40; Fas; IL 1; IL 18; TNF

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LYMPHOTOXIN; RECOMBINANT INTERLEUKIN 18; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOSTIMULATION; INFECTION; INFLAMMATION; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PERITONEUM MACROPHAGE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMAL; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-18; INTERLEUKIN-6; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIGENE FAMILY; RECOMBINANT PROTEINS; SPECIFIC PATHOGEN-FREE ORGANISMS; TUMOR NECROSIS FACTOR;

EID: 0033788437     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200010)30:10<3057::AID-IMMU3057>3.0.CO;2-P     Document Type: Article

References (23)

1. Interferon-γ inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effects independently of IL-12
2. Overview of interleukin-18: More than an interferon-γ inducing factor
3. Interleukin-18 and interleukin-1β: Two cytokine substrates for ICE (caspase-1)
4. IL-18 regulation of IFN-γ production and cell proliferation as revealed in interleukin-1β converting enzyme-deficient mice
5. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
6. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
7. Response to local inflammation of interleukin-1β converting enzyme-deficient mice
8. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme
9. Mice deficient in interleukin-1β converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
10. Interleukin-1β converting enzyme inhibition blocks progression of type II-collagen-induced arthritis in mice
11. Interleukin-18 activated NF-κB in murine T helper type 1 cells
12. + human mononuclear cells
13. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
14. Interleukin-18 inhibits osteoclast formation via T cell production of granulcyte macrophage colony-stimulating factor
15. Immunoregulatory effects of Fas-mediated signalling
16. CD40 ligand stimulates proinflammatory cytokine production by human endothelial cells
17. CD40/CD40L interactions are required for T cell-dependent production of interleukin-12 by mouse macrophages
18. Interleukin-18 enhances Fas ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells
19. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
20. Mice heterozygous for a deletion of the tumor necrosis factor-α and lymphotoxin-α genes: Biological importance of a non-lingar response of tumor necrosis factor-α to gene dosage
21. Lpr and gld single gene models of systemic autoimmunity and lymphoproliferative disease
22. Recombinant interferon-γ enhances resistance to acute disseminated Candida albicans infection in mice
23. Low-density-lipoprotein receptor deficient mice are protected against lethal endotoxinemia and severe Gram-negative infections