IL-18 improves the early antimicrobial host response to pneumococcal pneumonia

Journal of Immunology

Volumn 168, Issue 1, 2002, Pages 372-378

  Lauw, F N ^a   Branger, J ^a   Florquin, S ^a   Speelman, P ^a   Van Deventer, S J H ^a   Akira, S ^a   Van der Poll, T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 18; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; TUMOR NECROSIS FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL PNEUMONIA; CONTROLLED STUDY; HISTOLOGY; IMMUNE RESPONSE; LOBAR PNEUMONIA; LUNG LAVAGE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

EID: 0036135576     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.1.372     Document Type: Article

References (45)

1. Community-acquired pneumonia
2. Community-acquired pneumonia
3. Drug-resistant Streptococcus pneumoniae
4. Role of cytokines in pulmonary antimicrobial host defense
5. Endotoxin-induced serum factor that stimulates γ interferon production
6. A novel costimulatory factor for γ interferon induction found in the liver of mice causes endotoxic shock
7. The role of IL-18 in innate immunity
8. Interleukin-18, a proinflammatory cytokine
9. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
10. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
11. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interieukin-12 for interferon-γ production
12. IFN-y-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
13. Defective NK cell activity and Th1 response in IL-18-deficient mice
14. + human blood mononuclear cells
15. Interleukin-18 induces production of proinflammatory cytokines in mice: No intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1β
16. IFN-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine NK cell clones
17. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
18. IFN-γ-inducing factor/IL-18 administration mediates IFN-γ- and IL-12-independent antitumor effects
19. Cloning of a new cytokine that induces IFN-γ production by T cells
20. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escheriehia coli and Salmonelia ryphimurium endotoxemia
21. IL-18 (IFN-γ- inducing factor) regulates early cytokine production in, and promotes resolution of bacterial infection in mice
22. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
23. Interleukin 18 contributes to host resistance and γ interferon production in mice infected with virulent Salmonella typhimurium
24. Interleukin-10 impairs host defense in murine pneumococcal pneumonia
25. Passive immunization against tumor necrosis factor-α impairs host defense during pneumococcal pneumonia in mice
26. Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia
27. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
28. IL-12-induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor
29. Interleukin-18 regulation of interferon γ production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice
30. Production of γ interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: Regulation by interleukin-10, interleukin-12, and tumor necrosis factor α
31. Elevated plasma concentrations of interferon-γ (IFN-γ) and the IFN-γ-inducing cytokines interleukin-18 (IL-18), IL-12 and IL-15 in severe melioidosis
32. Airway epithelium expresses interleukin-1β
33. Regulation of IL-18 (IFN-γ-inducing factor) gene expression
34. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells
35. Host defenses against respiratory infection
36. Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumonia
37. Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice
38. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia
39. Role of tumor necrosis factor α in pathogenesis of pneumococcal pneumonia in mice
40. Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia
41. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia
42. IL-12 gene therapy protects mice in lethal Klebsiella pneumonia
43. Role of γ interferon in the pathogenesis of bacteremic pneumococcal pneumonia
44. Interleukin-12 deficient mice have intact defense mechanisms against pneumococcal pneumonia in spite of defective interfaron-γ production
45. The role of interferon-γ in murine pneumococcal pneumonia