Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis

European Journal of Immunology

Volumn 32, Issue 1, 2002, Pages 261-269

  Camoglio, Luisa ^a,d   Juffermans, Nicole P ^a   Peppelenbosch, Maikel ^a   Te Velde, Anje A ^a   Ten Kate, Fibo J ^a   Van Deventer, Sander J H ^a   Kopf, Manfred ^b,c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Colitis; IL 12; Inflammation; Th1; Th2

Indexed keywords

CYTOKINE; DIMER; GAMMA INTERFERON; HAPTEN; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; NEUTRALIZING ANTIBODY; PROTEIN P35; PROTEIN P40; PROTEIN SUBUNIT; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; COLITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; INFLAMMATION; LAMINA PROPRIA; MOUSE; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; TH1 CELL; WILD TYPE;

ANIMALS; BASEMENT MEMBRANE; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COLON; CROHN DISEASE; DISEASE MODELS, ANIMAL; FEMALE; HAPTENS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; T-LYMPHOCYTES; TRINITROBENZENESULFONIC ACID;

EID: 0036149971     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200201)32:1<261::AID-IMMU261>3.0.CO;2-X     Document Type: Article

References (39)

1. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
2. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
3. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
4. + T cells
5. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon by T cells
6. + T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type 1 response and ability to transfer disease
7. Induction and prevention of colonic inflammation in IL-2-deficient mice
8. Effect of IL-12 and antibodies to IL-12 on established granulomatous colitis in mice
9. IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
10. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
11. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice
12. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses
13. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
14. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
15. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer
16. Characterization of IL-12 receptor beta1 chain (IL-12Rbeta1)-deficient mice: IL-12Rbeta1 is an essential component of the functional mouse IL-12 receptor
17. Regional specialization in the mucosal immune system: Primed cells do not always home along the same track
18. Hapten-induced model of murine inflammatory bowel disease: Mucosa immune responses and protection by tolerance
19. IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2
20. Cloning of a new cytokine that induces IFN-gamma production by T cells
21. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
22. Interleukin 18: A pleiotropic participant in chronic inflammation
23. Neutralization of IL-12 decreases resistance to Listeria in SCID and C.B-17 mice. Reversal by IFN-gamma
24. Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guerin in IL-12-deficient mice
25. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii
26. IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection
27. Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
28. In vivo production and function of IL-12 p40 homodimers
29. Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock
30. Alloantigen-reactive Th1 development in IL-12-deficient mice
31. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans
32. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation
33. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
34. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin
35. An interleukin 12-related cytokine is up-regulated in ulcerative colitis but not in Crohn's disease
36. Development of Th1-type immune responses requires the type I cytokine receptor TCCR
37. IL-18, a novel immunoregulatory cytokine, is upregulated in Crohn's disease: Expression and localization in intestinal mucosal cells
38. Bioactive IL-18 expression is up-regulated in Crohn's disease
39. Monoclonal antibody therapy of inflammatory bowel disease