IL-18-binding protein expression by endothelial cells and macrophages is up-regulated during active Crohn's disease

Journal of Immunology

Volumn 168, Issue 7, 2002, Pages 3608-3616

  Corbaz, Anne ^a   Ten Hove, Tessa ^a   Herren, Suzanne ^a   Graber, Pierre ^a   Schwartsburd, Boris ^a   Belzer, Ilana ^a   Harrison, Jillian ^a   Plitz, Thomas ^a   Kosco Vilbois, Marie H ^a   Kim, Soo Hyun ^a   Dinarello, Charles A ^a   Novick, Daniela ^a   Van Deventer, Sander ^a   Chvatchko, Yolande ^a  

^a SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INTERLEUKIN 18 BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DISEASE ASSOCIATION; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036533668     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.7.3608     Document Type: Article

References (30)

1. Studies of peripheral blood lymphocytes in Crohn's disease: Circulating activated T cells
2. Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease: In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens
3. Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease
4. Effector and regulatory lymphoid cells and cytokines in mucosal sites
5. Cytokines in intestinal inflammation: Pathophysiological and clinical considerations
6. Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease: A novel mechanism of chronic intestinal inflammation
7. Experimental models of inflammatory bowel disease
8. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease
9. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
10. Endotoxin-induced serum factor that stimulates γ interferon production
11. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
12. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-γ production
13. + human blood mononuclear cells
14. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
15. IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
16. Bioactive IL-18 expression is up-regulated in Crohn's disease
17. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Expression and localization in intestinal mucosal cells
18. Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn's disease lesions
19. Interleukin 18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease
20. Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
21. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
22. Interferon-γ mediates gene expression of IL-18 binding protein in nonleukocytic cells
23. Expression and release of IL-18 binding protein in response to IFN-γ
24. A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18
25. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp
26. Identification and initial characterization of four novel members of the interleukin-1 family
27. Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production
28. Neutralization of IL-18 exerts anti-inflammatory activity in experimental colitis in mice
29. IL-18 is a primary mediator of inflammation associated with DSS-induced colitis: Blocking IL-18 prevents intestinal damage
30. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both