Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1145-1152

  Melnikov, Vyacheslav Y ^a   Ecder, Tevfik ^a   Fantuzzi, Giamila ^a   Siegmund, Britta ^a   Lucia, M Scott ^a   Dinarello, Charles A ^a   Schrier, Robert W ^a   Edelstein, Charles L ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; NEUTRALIZING ANTIBODY; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HISTOPATHOLOGY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY TUBULE NECROSIS; MOUSE; MOUSE STRAIN; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; UREA NITROGEN BLOOD LEVEL;

EID: 0035015397     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI12089     Document Type: Article

References (31)

1. Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A
2. Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules
3. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
4. A license to kill
5. Biologic basis for interleukin-1 in disease
6. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1 beta-converting enzyme (caspase-1)-deficient mice
7. Altered cytokine export and apoptosis in mice deficient in interleukin-1B converting enzyme
8. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock
9. Effect of endotoxin in IL-1 beta-deficient mice
10. Role of IL-1 in renal ischemic reperfusion injury
11. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
12. Down-regulation of the calpain inhibitor protein, calpastatin, by caspases during renal ischemia
13. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
14. Assessment of myeloperoxidase activity in whole rat kidney
15. Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme)
16. Increased concentrations of plasma IL-18 in patients with hepatic dysfunction after hepatectomy
17. Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice
18. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor
19. Apoptosis of sinusoidal endothelial cells occurs during liver preservation injury by a caspase-dependent mechanism
20. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
21. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production
22. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3
23. Hypoxia induces intercellular adhesion molecule-1 on cultured human tubular cells
24. Interleukin-1 treatment increases neutrophils but not antioxidant enzyme activity or resistance to ischemia-teperfusion injury in rat kidneys
25. Expression of interleukin-18 in the lung after endotoxemia or hemorrhage-induced acute lung injury
26. Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation
27. Ischemia-reperfusion-induced IFN-gamma up-regulation: Involvement of IL-12 and II-18
28. Neutrophils and renal failure
29. Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells
30. IL-18 regulates IL-1beta-dependent hepatic melanoma metastasis via vascular cell adhesion molecules
31. Intracellular adhesion molecule-1 deficient mice are protected against ischemic renal injury