Interleukin-18 and Crohn's disease

Digestion

Volumn 63, Issue SUPPL. 1, 2001, Pages 37-42

  Kanai, Takanori ^a   Watanabe, Mamoru ^b   Okazawa, Akira ^a   Sato, Toshiro ^a   Hibi, Toshifumi ^a,c  

^a KEIO UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c Keio Caner Center   (Japan)

Author keywords

Crohn's disease; Interleukin 18; Proinflammatory cytokine; Th1

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 18;

CONFERENCE PAPER; CROHN DISEASE; CYTOKINE RELEASE; HELPER CELL; HUMAN; MACROPHAGE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD4; CROHN DISEASE; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-18; INTESTINAL MUCOSA; MICE; T-LYMPHOCYTES;

EID: 0035137669     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000051909     Document Type: Conference Paper

References (42)

1. Inflammatory bowel disease (first of two)
2. Tumor necrosis factor a-producing cells in the intestinal mucosa of children with inflammatory bowel disease
3. Cytokines and growth factors in inflammatory bowel disease
4. Cloning of a new cytokine that induces IFN-γ production by T cells
5. Regulation of interferon-γ production by IL-12 and IL-18
6. Interleukin-18
7. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studied on the biologic activities of the protein
8. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
9. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
10. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
11. Characterization of anti-human interleukin-18 (IL-18)/interleukin-γ-inducing factor (IGIF) monoclonal antibodies and their application in the measurement of human IL-18 by ELISA
12. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFkB
13. Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
14. Preferential activation of CD4+Vb5.2/5.3+ intestinal epithelial lymphocytes in the inflamed lesions of Crohn's disease
15. A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis
16. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells
17. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
18. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
19. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
20. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease
21. Purification and characterization of the human interleukin-18 receptor
22. Cloning of a novel receptor subunit, AcPL, required for Interleukin 18 signaling
23. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
24. MyD genes in negative growth control
25. A cytokine-response IkB kinase that activates the transcrition factor NF-kB
26. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells and B cells: Synergism with IL-18 for IFN-γ production
27. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Expression and localization in intestinal mucosal cells
28. Bioactive IL-18 expression is up-regulated in Crohn's disease
29. IL-18 is a potent proliferative factor for intestinal mucosal lymphocytes in Crohn's disease
30. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-g promoter in primary CD4+ T lymphocytes
31. An essential role for NFκB in IL-18-induced IFN-g expression in KG-1 cells
32. Experimental models of inflammatory bowel disease
33. Mucosal immunoregulation and inflammatory bowel disease: New insights from murine models of inflammation
34. Recognition and lysis of altered-self cells by macrophages. Modification of target cells by 2,4,6-trinitrobenzene sulfonic acid
35. Antibodies to interleukin 12 abrogate established experimental colitis in mice
36. Upregulation of the IL-12/STAT-4 signaling pathway distinguishes Crohn's disease from ulcerative colitis
37. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease
38. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
39. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
40. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils