Neurotrophins: Roles in neuronal development and function

Annual Review of Neuroscience

Volumn 24, Issue , 2001, Pages 677-736

  Huang, E J ^a   Reichardt, L F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Differentiation; Nerve growth factor; Plasticity; Signaling; Survival; Synapse; Trk receptor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; PROTEIN CDC42; PROTEIN P75; RAS PROTEIN; TYROSINE KINASE RECEPTOR;

APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; DENDRITE; NERVE CELL; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FUNCTION; NERVE GROWTH; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; HUMANS; ION CHANNELS; MAP KINASE SIGNALING SYSTEM; MODELS, NEUROLOGICAL; NERVE GROWTH FACTORS; NEURONS; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; VERTEBRATES;

EID: 0034927081     PISSN: 0147006X     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.neuro.24.1.677     Document Type: Review

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214. GFR-alpha-3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion
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233. Role of brain-derived neurotrophic factor in target invasion in the gustatory system
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236. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site
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238. Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation
239. Neurotrophins: Structural relatedness and receptor interactions
240. Point mutations affecting the tyrosine kinase domain of the RET protooncogene in Hirschsprung's disease
241. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR-alpha-2, a functional neurturin receptor
242. Nerve growth factor NT-5 induce increased thermal sensitivity of cutaneous nociceptors in vitro
243. Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures
244. BDNF has opposite effects on the quantal amplitude of pyramidal neuron and interneuron excitatory synapses
245. Functional analysis of mutant neurotrophins deficient in low-affinity binding reveals a role for p75LNGFR in NT-4 signalling
246. NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
247. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
248. A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals
249. Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets
250. Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation
251. Effects of BDNF and NT-3 on development of Ia/motoneuron functional connectivity in neonatal rats
252. Intracellular signaling pathways activated by neurotrophic factors
253. Human Trks: Molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
254. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity
255. Identification of a signaling pathway involved in calcium regulation of BDNF expression
256. Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro
257. Effects of TrkB and TrkC neurotrophin receptor agonists on thermal nociception: A behavioral and electrophysiological study
258. Neurotrophins and hyperalgesia
259. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin
260. Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells
261. The neural crest colony assay: Assessing molecular influences in development in culture
262. BDNF and TrkB mRNA expression in neurons of the neonatal mouse barrel field cortex: Normal development and plasticity after cauterizing facial vibrissae
263. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
264. Tackling pain at the source: New ideas about nociceptors
265. TrkA-immunoreactive profiles in the central nervous system: Colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin
266. Nerve growth factor signaling, neuroprotection and neural repair
267. cAMP-induced switching in turning direction of nerve growth cones
268. Signal transduction underlying growth cone guidance by diffusible factors
269. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
270. A splice variant of the neurotrophin receptor TrkB with increased specificity for brain-derived neurotrophic factor
271. The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons
272. Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors
273. Overexpression of nerve growth factor in skin selectively affects the survival and functional properties of nociceptors
274. 4-positive and -negative nociceptors are functionally distinct
275. Diversity and pattern in the developing spinal cord
276. Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells
277. Inhibition of GABAa synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus
278. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism
279. Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system
280. Targeted deletion of all isoforms of the TrkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates TrkC in normal cardiogenesis
281. Physiology of nerve growth factor
282. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction
283. Rapid extragranular plasticity in the absence of thalamocortical plasticity in the developing primary visual cortex
284. TrkC isoforms with inserts in the kinase domain show impaired signaling responses
285. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
286. Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC
287. High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors
288. Depolarization and neurotrophins converge on the phosphatidylinositol 3-kinase-Akt pathway to synergistically regulate neuronal survival
289. Neurotrophins regulate sequential changes in neurotrophin receptor expression by sympathetic neuroblasts
290. p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells
291. A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts
292. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the Trk protooncogene
293. Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons
294. Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system
295. Enhanced neurotrophin-induced axon growth in myelinated portions of the CNS in mice lacking the p75 neurotrophin receptor
296. Absence of the p75 neurotrophin receptor alters the pattern of sympathosensory sprouting in the trigeminal ganglia of mice overexpressing nerve growth factor
297. Potentiation of developing synapses by postsynaptic release of neurotrophin-4
298. Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
299. The role of p75NTR in modulating neurotrophin survival effects in developing motoneurons
300. Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
301. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
302. Neurotrophin-3 is a survival factor in vivo for early mouse trigeminal neurons
303. Transcriptional and posttranslational plasticity and the generation of inflammatory pain
304. A role for the SHP-2 tyrosine phosphatase in nerve growth-induced PC12 cell differentiation
305. Sympathetic neuron survival and TrkA expression in NT3-deficient mouse embryos
306. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
307. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
308. Coupling of the RAS-MAPK pathway to gene activation of RSK2, a growth factor-regulated CREB kinase
309. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation
310. The role of BDNF receptors in the mature hippocampus: Modulation of long term potentiation through a presynaptic mechanism
311. Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
312. Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signalling in cultured rat cerebral cortical neurons
313. Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons
314. Insulin receptor substrate (IRS)-2 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic factor in cultured cerebral cortical neurons
315. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells
316. Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
317. Absence of excitotoxicity-reduced apoptosis in the hippocampus of mice lacking the Jnk3 gene
318. Association of the Ab1 tyrosine kinase with the Trk nerve growth factor receptor
319. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
320. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival
321. Role of phosphoinositide 3-kinase and endocytosis in NGF induced extracellular signal-regulated kinase activation via Ras and Rap1
322. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
323. Apoptosis in the nervous system
324. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
325. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
326. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide