Cell surface Trk receptors mediate NGF-Induced survival while internalized receptors regulate NGF-Induced differentiation

Journal of Neuroscience

Volumn 20, Issue 15, 2000, Pages 5671-5678

  Zhang, Yan Zhen ^a,b   Moheban, Daniel B ^a,b   Conway, Bevil R ^a   Bhattacharyya, Anita ^b   Segal, Rosalind A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Akt; Dynamin; Endocytosis; Nerve growth factor; Neurotrophin; Receptor tyrosine kinase; Survival

Indexed keywords

DYNAMIN; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOCYTOSIS; INTERNALIZATION; MOLECULAR INTERACTION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION;

EID: 0034255428     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-15-05671.2000     Document Type: Article

References (52)

1. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin)
2. Anterograde transport of brain-derived neurotrophic factor and its role in the brain
3. Raf meets Ras: Completing the framework of a signal transduction pathway
4. Role of dynamin in clathrin-coated vesicle formation
5. A signaling endosome hypothesis to explain NGF actions: Potential implications for neurodegeneration
6. Endosomes, receptor tyrosine kinase internalization and signal transduction
7. Trk receptors function as rapid retrograde signal carriers in the adult nervous system
8. Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes
9. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways
10. Neurotrophin receptors: A window into neuronal differentiation
11. Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons
12. Anterograde transport of neurotrophin proteins in the CNS: A reassessment of the neurotrophic hypothesis
13. Human trk oncogenes activated by point mutation, in-frame deletion and duplication of the tyrosine kinase domain
14. Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
15. Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin
16. The function of dynamin in endocytosis
17. Ras signalling and apoptosis
18. A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo
19. Regulation of neuronal survival by the serine-threonine protein kinase Akt
20. NGF-stimulated retro-grade transport of trk A in the mammalian nervous system
21. Nerve growth factor nonresponsive pheochromocytoma cells: Altered internalization results in signaling dysfunction
22. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
23. PC12 Pheochromocytoma cultures in neurobiological research
24. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
25. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA
26. Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway
27. Dynamin-mediated internalization of caveolae
28. Molecular characteristics of nerve growth factor receptors on PC12 cells
29. Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase
30. Regulation of signal transduction and signal diversity by receptor oligomerization
31. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
32. A novel juxtamembrane deletion in rat TrkA blocks differentiative but not mitogenic cell signaling in response to nerve growth factor
33. Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium
34. Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis
35. Identification and characterization of novel substrates of Trk receptors in developing neurons
36. PC12 Cell neuronal differentiation is associated with prolonged p21 ras activity and consequent prolonged ERK activity
37. An NGF-Trka-mediated retrograde signal to transcription factor CREB in sympathetic neurons
38. A TrkA-selective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals
39. Abnormal cerebellar development and foliation in BDNF -/- mice reveals a role for neurotrophins in CNS patterning
40. Differential utilization of Trk autophosphorylation sites
41. Rapid retrograde tyrosine phosphorylation of TrkA and other proteins in rat sympathetic neurons in compartmented cultures
42. Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses
43. Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth
44. Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons
45. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
46. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
47. Neurite outgrowth in peripherin-depleted PC12 cells
48. Characterization of an NGF-P-trkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
49. Control of EGF receptor signaling by clathrin-mediated endocytosis
50. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
51. TrkA glycosylation regulates receptor localization and activity
52. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor