Neurotrophins induce death of hippocampal neurons via the p75 receptor

Journal of Neuroscience

Volumn 20, Issue 17, 2000, Pages 6340-6346

  Friedman, Wilma J ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Apoptosis; Jun kinase; Neurotrophin receptors; Neurotrophins; NGF; P75

Indexed keywords

CELL RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN P75; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL DIFFERENTIATION; CELL SUBPOPULATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRUCTURE ANALYSIS;

EID: 0034279150     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-17-06340.2000     Document Type: Article

References (66)

1. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture
2. Regulation of neurotrophin receptors during the maturation of the mammalian visual system
3. P53 is essential for developmental neuron death as regulated by the trkA and p75 neurotrophin receptors
4. Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo
5. Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase
6. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
7. Neurotrophins: A family of proteins supporting the survival of neurons
8. Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to trkA on PC12 cells
9. The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development
10. Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons
11. Differential expression of the nerve growth factor receptor gene in multiple brain areas
12. Neurotrophins live or let die: Does p75 decide?
13. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
14. Neurotrophins: The biological paradox of survival factors eliciting apoptosis
15. The p75 neurotrophin receptor
16. Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits
17. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
18. Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins
19. TrkB signalling inhibits p75-mediated apoptosis induced by NGF in embryonic proprioceptive neurons
20. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins
21. Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
22. Cells expressing mRNA for neurotrophins and their receptors during embryonic rat development
23. Neuroprotective actions of dipyridamole on cultured CNS neurons
24. Naturally occurring cell death in the subicular complex and hippocampus in the rat during development
25. Nerve growth factor: Two receptors, multiple functions
26. Induction of cell death by endogenous nerve growth factor through its p75 receptor
27. Control of early cell death by BDNF in the chick retina
28. In situ hybridization reveals both transient and persistent expression of HDNF/NT-3 mRNA in the rat brain during postnatal development
29. Differential actions of neurotrophins in the locus coeruleus and basal forebrain
30. Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: An immunocytochemical study
31. Naturally occurring cell death in the developing dentate gyrus of the rat
32. Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions
33. High affinity NGF binding requires co-expression of the trk proto-oncogene and the low affinity NGF receptor
34. Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor are distinguished during morphogenesis of transgenic animals
35. Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product
36. Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity
37. Cultured hippocampal neurons show responses to BDNF, NT3, and NT4, but not NGF
38. The trk proto-oncogene product is a receptor for nerve growth factor
39. Immunohistochemical localization of cells containing nerve growth factor receptors in the different regions of the adult rat forebrain
40. The trk proto-oncogene encodes a receptor for nerve growth factor
41. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
42. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
43. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
44. p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF
45. Expression of NGF and NGF receptor mRNAs in the developing brain: Evidence for local delivery and action of NGF
46. NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression
47. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
48. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by I1-1B
49. Differential involvement of metabotropic and p75 neurotrophin receptors in effects of nerve growth factor and neurotrophin-3 on cultured Purkinje cell survival
50. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death
51. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells
52. Is p75NGFR involved in developmental neural cell death?
53. Expression of members of the trk family in the developing postnatal rat brain
54. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure
55. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
56. Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor
57. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
58. Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth
59. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
60. Caspase-dependent and -independent death of camptothecin-treated embryonic cortical neurons
61. Caspase-2 mediates neuronal cell death induced by β-amyloid
62. p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells
63. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
64. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
65. An immunohistochemical study of the nerve growth factor receptor in developing rats
66. Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival