NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking

Journal of Neuroscience

Volumn 20, Issue 19, 2000, Pages 7325-7333

  Beattie, E C ^a   Howe, C L ^a   Wilde, A ^a   Brodsky, F M ^a   Mobley, W C ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

BDNF; Clathrin; Endocytosis; Neurotrophin; NGF; Signaling; Transferrin; TrkA

Indexed keywords

ADAPTOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CLATHRIN; NERVE GROWTH FACTOR; NEUROTROPHIN; PROTEIN TYROSINE KINASE; TRANSFERRIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; FLUORESCENCE MICROSCOPY; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

EID: 0034307565     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-19-07325.2000     Document Type: Article

References (49)

1. A signaling endosome hypothesis to explain NGF actions: Potential implications for neurodegeneration
2. Clathrin assembly protein AP-2 induces aggregation of membrane vesicles: A possible role for AP-2 in endosome formation
3. The tyrosine kinase substrate Eps15 is constitutively associated with the plasma membrane adaptor AP-2
4. Synaptic reliability correlates with reduced susceptibility to synaptic potentiation by brain-derived neurotrophic factor
5. Trk receptors function as rapid retrograde signal carriers in the adult nervous system
6. Clathrin structure characterized with monoclonal antibodies. I. Analysis of multiple antigenic sites
7. Neurotrophins in cell survival/death decisions
8. 100 kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis
9. Pit formation and rapid changes in surface morphology of sympathetic neurons in response to nerve growth factor
10. Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP
11. Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
12. Autophosphorylation of activation loop tyrosines regulates signaling by the TRK nerve growth factor receptor
13. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
14. NGF-stimulated retrograde transport of TrkA in the mammalian nervous system
15. Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors
16. NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
17. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
18. A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA
19. Synaptojanin 1: Localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15
20. Nerve growth factor signaling in caveolae-like domains at the plasma membrane
21. Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
22. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and non-neuronal cells
23. Signal transduction by the neurotrophin receptors
24. K-252a: A specific inhibitor of the action of nerve growth factor on PC12 cells
25. Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site
26. Regulation of TrkA and ChAT expression in developing rat basal forebrain - Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
27. Transfection with Trk restores slow NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants
28. The structural era of endocytosis
29. Clathrin interacts specifically with amphiphysin and is displaced by dynamin
30. Essential role for TrkB receptors in hippocampus-mediated learning
31. Characterization and isolation of proteolytically modified nerve growth factor
32. Folding and trimerization of clathrin subunits at the triskelion hub
33. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
34. Postsynaptic target specificity of neurotrophin-induced presynaptic potentiation
35. Clathrin-coated vesicle formation and protein sorting: An integrated process
36. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
37. Rapid retrograde tyrosine phosphorylation of TrkA and other proteins in rat sympathetic neurons in compartmented cultures
38. Molecular genetics of neuronal survival
39. Role of phosphorylation in regulation of the assembly of endocytic coat complexes
40. Functions of the neurotrophins during nervous system development: What the knock-outs are teaching us
41. Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits
42. Characterization of an NGF-P-TrkA retrograde signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
43. Association and colocalization of Eps15 with adaptor protein-2 and clathrin
44. TrkA glycosylation regulates receptor localization and activity
45. In vivo phosphorylation of adaptors regulates their interaction with clathrin
46. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
47. Early BDNF, NT-3, and NT-4 signaling events
48. Nerve growth factor and the neurotrophic factor hypothesis
49. Multiple levels for regulation of TrkA in PC12 cells by nerve growth factor