The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons

Journal of Neuroscience

Volumn 17, Issue 11, 1997, Pages 4398-4405

  Stucky, Cheryl L ^a   Koltzenburg, Martin ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

apoptosis; BDNF; dorsal root ganglion; electrophysiology; mechanosensation; NGF; nociceptor; NT 3; NT 4

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR;

AFFERENT NERVE GROUP 1; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SUBPOPULATION; CELL SURVIVAL; DEMYELINATION; MOUSE; MYELINATED NERVE; NERVE CELL DEGENERATION; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SENSORY NERVE CELL; SPINAL GANGLION;

EID: 0030979272     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-11-04398.1997     Document Type: Article

References (26)

1. Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M (1996) Specific sub-types of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16:287-295.
2. Albers KM, Perrone TN, Goodness TP, Jones ME, Green MA, Davis BM (1996) Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation. J Cell Biol 134:487-497.
3. Anand P (1996) Neurotrophins and peripheral neuropathy. Philos Trans R Soc Lond [Biol] 351:449-454.
4. Averill S, McMahon SB, Clary DO, Reichardt LF, Priestley JV (1995) Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci 7:1484-1494.
5. Barbacid M (1994) The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
6. Barker PA, Shooter EM (1994) Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13:203-215.
7. Benedetti M, Levi A, Chao MV (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci USA 90:7859-7863.
8. Bennett DLH, McMahon SB, Shelton D, Koltzenburg M (1996) NGF sequestration using a trkA-IgG fusion molecule prevents primary afferent sensitisation to carrageenan inflammation. 8th World Congress Pain Abstr 8:120.
9. Berg MM, Sternberg DW, Hempstead BL, Chao MV (1991) The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proc Natl Acad Sci USA 88:7106-7110.
10. Bergmann I, Priestley JV, McMahon SB, Broker EB, Toyka KV, Koltzenburg M (1997) Analysis of cutaneous sensory neurones in transgenic mice lacking the low affinity neurotrophin receptor p75. Eur J Neurosci 9:18-28.
11. Carroll SL, Silos-Santiago I, Frese SE, Ruit KG, Milbrandt J, Snider WD (1992) Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron 9:779-788.
12. Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA (1996) Selective activation of NFκB by nerve growth factor through the neurotrophin receptor p75. Science 272:542-545.
13. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, Ling LH, McMahon SB, Shelton DL, Levinson AD, Phillips HS (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011.
14. Curtis R, Adryan KM, Stark JL, Park JS, Compton DL, Weskamp G, Huber LJ, Chao MV, Jaenisch R, Lee KF, Lindsay RM, DiStefano PS (1995) Differential role of the low affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins. Neuron 14:1201-1211.
15. Diamond J, Lourenssen S, Pertens E, Urschel B (1995) Lack of collateral sprouting of nociceptive nerves in adult p75 knock-out mice. Soc Neurosci Abstr 21:1539.
16. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265:1596-1599.
17. Dobrowsky RT, Jenkins GM, Hannun YA (1995) Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem 270:22135-22142.
18. Ernfors P, Lee KF, Kucera J, Jaenisch R (1994) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503-512.
19. Farinas I, Jones KR, Backus C, Wang XY, Reichardt LF (1994) Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369:658-661.
20. Forster C, Handwerker HO (1990) Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 31:109-118.
21. Hallböök F, Ibáñez CF, Persson H (1991) Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6:845-858.
22. Hempstead BL, Martin-Zanca D, Kaplan DR, Parada LF, Chao MV (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 350:678-683.
23. Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368:249-251.
24. Koltzenburg M (1996) Stability and plasticity of nociceptor function and their relationship to provoked and ongoing pain. Semin Neurosci 7:199-210.
25. Koltzenburg M, Lewin GR, Toyka KV, Thoenen H, Carroll P (1995) Electrophysiological analysis of cutaneous sensory neurons in neonatal wild type mice and transgenic animals lacking BDNF. Soc Neurosci Abstr 21:154.
26. Koltzenburg M, Bennett DLH, Shelton DL, Toyka KV, McMahon SB (1996) Sequestration of endogenous nerve growth factor (NGF) in adult rat reduces the sensitivity of nociceptors. 8th World Congress Pain Abstr 8:120.