TrkB isoforms with distinct neurotrophin specificities are expressed in predominantly nonoverlapping populations of avian dorsal root ganglion neurons

Journal of Neuroscience

Volumn 19, Issue 12, 1999, Pages 4739-4747

  Boeshore, Kristen L ^a   Luckey, Carol N ^a   Zigmond, Richard E ^a   Large, Thomas H ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Sphinx Pharmaceuticals   (United States)

Author keywords

Alternative splicing; Chicken; Dorsal root ganglia; Neurotrophin specificity; Single cell RT PCR; TrkB

Indexed keywords

ASPARTIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; RECEPTOR SUBTYPE; TYROSINE KINASE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SEQUENCE ANALYSIS; SPINAL GANGLION;

EID: 0033564393     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-12-04739.1999     Document Type: Article

References (37)

1. Barbacid M (1994) The trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
2. Barker PA, Lomen HC, Gensch EM, Meakin SO, Glass DJ, Shooter EM (1993) Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem 268:15150-15157.
3. Benedetti M, Levi A, Chao MV (1993) Differential expression of nerve growth factor receptor leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci USA 90:7859-7863.
4. Chomczynski P (1992) One hour downward alkaline capillary transfer for blotting of DNA and RNA. Anal Biochem 201:134-139.
5. Clary DO, Reichardt LF (1994) An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc Natl Acad Sci USA 91:11133-11137.
6. Cohen-Cory S, Fraser SE (1995) Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo. Nature 378:192-196.
7. Conover JC, Erickson JT, Katx DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P, Friedman B, Wiegand S, Vejsada R, Kato AC, DeChiara TM, Yancopoulos GD (1995) Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature 375:235-238.
8. Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos GD, Katz DM (1996) Mice lacking brain-derived neurotrophic factor exhibit visceral sensory losses distinct from mice lacking NT-4 and display a severe developmental deficit in control of breathing. J Neurosci 16:5361-5371.
9. Farinas I, Wilkinson GA, Backus C, Reichardt LF, Patapoutian A (1998) Characterization of neurotrophin and trk receptor functions in developing sensory ganglia: direct NT-3 activation of trkB neurons in vivo. Neuron 21:325-334.
10. Garner AS, Menegay HJ, Boeshore KL, Xie XY, Voci JM, Johnson JE, Large TH (1996) Expression of trkB receptor isoforms in the developing avian visual system. J Neurosci 16:1740-1752.
11. Hamburger V, Hamilton H (1951) A series of normal stages in the development of the chick embryo. J Morphol 88:49-92.
12. Hughes SH, Greenhouse JJ, Petropoulos CJ, Sutrave P (1987) Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J Virol 61:3004-3012.
13. Ibanez CF, Ilag LL, Murray-Rust J, Persson H (1993) An extended surface of binding to trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin. EMBO J 12:2281-2293.
14. Hag LL, Lennerberg P, Persson H, Ibanez CF (1994) Role of variable B-hairpin loops in determining biological specificities in neurotrophin family. J Biol Chem 269:19941-19946.
15. Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA, Barbacid M, Yancopoulos GD (1993) Similarities and differences in the way neurotrophins interact with the trk receptors in neuronal and non-neuronal cells. Neuron 10:137-149.
16. Klein R, Lamballe F, Bryant S, Barbacid M (1992) The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8:947-956.
17. Korsching S (1993) The neurotrophic factor concept: a reexamination. J Neurosci 13:2739-2748.
18. Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (1997) A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the ras/MAPK signaling pathway. Cell 89:693-702.
19. Lindsay RM (1994) Neurotrophins and receptors. Prog Brain Res 103:3-14.
20. Liu X, Ernfors P, Wu H, Jaenisch R (1995) Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375:238-241.
21. Lo DC (1995) Neurotrophic factors and synaptic plasticity. Neuron 15:979-981.
22. McAllister AK, Lo DC, Katz LC (1995) Neurotrophins regulate dendritic growth in developing visual cortex. Neuron 15:791-803.
23. Meakin SO, Suter U, Drinkwater CC, Welcher AA, Shooter EM (1992) The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc Natl Acad Sci USA 89:2374-2378.
24. Minichiello L, Casagranda F, Tatche RS, Stucky CL, Postigo A, Lewin GR, Davies AM, Klein R (1998) Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron 21:335-345.
25. Obermeier A, Lammer R, Wiesmuller KH, Jung G, Schlessinger J, Ullrich A (1993) Identification of trk binding sites for She and phosphatidylinositol 3́-kinase and formation of a multimeric signaling complex. J Biol Chem 268:22963-22966.
26. Peng X, Greene LA, Kaplan DR, Stephens RM (1995) Deletion of a conserved juxtamembrane sequence in trk abolishes NGF-promoted neuritogenesis. Neuron 15:395-406.
27. Perez P, Coll PM, Hempstead BL, Martin-Zanca D, Chao M (1995) NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Mol Cell Neurosci 6:97-105.
28. Riddle DR, Lo DC, Latz LC (1995) MT-4 mediated rescue of lateral geniculate neurons from effects of monocular deprivation. Nature 378:189-191.
29. Ryden M, Ibanez CF (1996) Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC. J Biol Chem 271:5623-5627.
30. LNGFR in NT-4 signalling. EMBO J 14:1979-1990.
31. Shelton DL, Sutherland J, Gripp J, Camerato T, Armanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesions. J Neurosci 15:477-491.
32. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77:627-638.
33. Strohmaier C, Carter BD, Urfer R, Barde YA, Dechant G (1996) A splice variant of the neurotrophin receptor rkB with increased specificity for brain-derived neurotrophic factor. EMBO J 15:3332-3337.
34. Thoenen H (1995) Neurotrophins and neuronal plasticity. Science 270:593-598.
35. Urfer R, Tsoulfas P, O'Conell L, Shelton DL, Parada LF, Presta LG (1995) An immunoglobulin-like domain determines the specificity of neurotrophin receptors. EMBO J 14:2785-2805.
36. Von Bartheld CS, Williams R, Lefcort F, Clary DO, Reichardt LF, Bothwell M (1996) Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J Neurosci 16:2995-3008.
37. Williams R, Ebendal T (1995) Neurotrophin receptor expression during development of the chick spinal sensory ganglion. NeuroReport 6:2277-2282.