-
1
-
-
12644317846
-
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways
-
Arbiser, J. L., M. A. Moses, C. A. Fernandez, N. Ghiso, Y. Cao, N. Klauber, D. Frank, M. Brownlee, E. Flynn, S. Parangi, H. R. Byers, and J. Folkman. 1997. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc. Natl. Acad. Sci. USA 94:861-866.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 861-866
-
-
Arbiser, J.L.1
Moses, M.A.2
Fernandez, C.A.3
Ghiso, N.4
Cao, Y.5
Klauber, N.6
Frank, D.7
Brownlee, M.8
Flynn, E.9
Parangi, S.10
Byers, H.R.11
Folkman, J.12
-
2
-
-
0029551217
-
Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation
-
Bornfeldt, K. E., E. W. Raines, L. M. Graves, M. P. Skinner, E. G. Krebs, and R. Ross. 1995. Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation. Ann. N. Y. Acad. Sci. 766:416-430.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.766
, pp. 416-430
-
-
Bornfeldt, K.E.1
Raines, E.W.2
Graves, L.M.3
Skinner, M.P.4
Krebs, E.G.5
Ross, R.6
-
3
-
-
0029148660
-
Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
-
Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R. Kolesnick. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82:405-414.
-
(1995)
Cell
, vol.82
, pp. 405-414
-
-
Bose, R.1
Verheij, M.2
Haimovitz-Friedman, A.3
Scotto, K.4
Fuks, Z.5
Kolesnick, R.6
-
5
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet, A., A. Bonni, M. J. Zigmond, M. Z. Lin, P. Juo, L. S. Hu, M. J. Anderson, K. C. Arden, J. Blenis, and M. E. Greenberg. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
6
-
-
0031944521
-
Down-regulation of Fas gene expression in colon cancer is not a result of allelic loss or gene rearrangement
-
Butler, L. M., P. J. Hewett, W. J. Butler, and P. A. Cowled. 1998. Down-regulation of Fas gene expression in colon cancer is not a result of allelic loss or gene rearrangement. Br. J. Cancer 77:1454-1459.
-
(1998)
Br. J. Cancer
, vol.77
, pp. 1454-1459
-
-
Butler, L.M.1
Hewett, P.J.2
Butler, W.J.3
Cowled, P.A.4
-
7
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96:4240-4245.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
8
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone, M. H., N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Frisch, and J. C. Reed. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
9
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
-
Chang, H. W., M. Aoki, D. Fruman, K. R. Auger, A. Bellacosa, P. N. Tsichlis, L. C. Cantley, T. M. Roberts, and P. K. Vogt. 1997 Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science 276:1848-1850.
-
(1997)
Science
, vol.276
, pp. 1848-1850
-
-
Chang, H.W.1
Aoki, M.2
Fruman, D.3
Auger, K.R.4
Bellacosa, A.5
Tsichlis, P.N.6
Cantley, L.C.7
Roberts, T.M.8
Vogt, P.K.9
-
10
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
11
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
12
-
-
0032533225
-
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
-
Diehl, J. A., M. Cheng, M. F. Roussel, and C. J. Sherr. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12:3499-3511.
-
(1998)
Genes Dev.
, vol.12
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
13
-
-
0032577647
-
Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain
-
Engelman, J. A., C. Chu, A. Lin, H. Jo, T. Ikezu, T. Okamoto, D. S. Kohtz, and M. P. Lisanti. 1998. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 428:205-211.
-
(1998)
FEBS Lett.
, vol.428
, pp. 205-211
-
-
Engelman, J.A.1
Chu, C.2
Lin, A.3
Jo, H.4
Ikezu, T.5
Okamoto, T.6
Kohtz, D.S.7
Lisanti, M.P.8
-
14
-
-
0026652899
-
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
-
Fantl, W. J., J. A. Escobedo, G. A. Martin, C. W. Turck, M. del Rosario, F. McCormick, and L. T. Williams. 1992. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69:413-423.
-
(1992)
Cell
, vol.69
, pp. 413-423
-
-
Fantl, W.J.1
Escobedo, J.A.2
Martin, G.A.3
Turck, C.W.4
Del Rosario, M.5
McCormick, F.6
Williams, L.T.7
-
15
-
-
0030753816
-
Lipid domains in the membrane: Thermotropic properties of sphingomyelin vesicles containing GM1 ganglioside and cholesterol
-
Ferraretto, A., M. Pitto, P. Palestini, and M. Masserini. 1997. Lipid domains in the membrane: thermotropic properties of sphingomyelin vesicles containing GM1 ganglioside and cholesterol. Biochemistry 36:9232-9236.
-
(1997)
Biochemistry
, vol.36
, pp. 9232-9236
-
-
Ferraretto, A.1
Pitto, M.2
Palestini, P.3
Masserini, M.4
-
17
-
-
0026033808
-
Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts
-
Fukui, Y., A. R. Saltiel, and H. Hanafusa. 1991. Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts. Oncogene 6:407-411.
-
(1991)
Oncogene
, vol.6
, pp. 407-411
-
-
Fukui, Y.1
Saltiel, A.R.2
Hanafusa, H.3
-
18
-
-
0031892776
-
Microsatellitc deletion mapping on chromosome 10q and mutation analysis of MMAC1. FAS, and MXI1 in human glioblastoma multiforme
-
Fults, D., C. A. Pedone, G. E. Thompson, C. M. Uchiyama, K. L. Gumpper, D. Iliev, V. L. Vinson, S. V. Tavligian, and W. L. Perry III. 1998. Microsatellitc deletion mapping on chromosome 10q and mutation analysis of MMAC1. FAS, and MXI1 in human glioblastoma multiforme. Int. J. Oncol. 12:905-910.
-
(1998)
Int. J. Oncol.
, vol.12
, pp. 905-910
-
-
Fults, D.1
Pedone, C.A.2
Thompson, G.E.3
Uchiyama, C.M.4
Gumpper, K.L.5
Iliev, D.6
Vinson, V.L.7
Tavligian, S.V.8
Perry W.L., III.9
-
19
-
-
0032516835
-
Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
-
Furuchi, T., and R. G. Anderson. 1998. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J. Biol. Chem. 273:21099-21104.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21099-21104
-
-
Furuchi, T.1
Anderson, R.G.2
-
20
-
-
0032515945
-
Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster
-
Galbiati, F., D. Volonte, J. S. Goltz, Z. Steele, J. Sen, J. Juresak, D. Stein, L. Stevens, and M. P. Lisanti. 1998. Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster. Gene 210:229-237.
-
(1998)
Gene
, vol.210
, pp. 229-237
-
-
Galbiati, F.1
Volonte, D.2
Goltz, J.S.3
Steele, Z.4
Sen, J.5
Juresak, J.6
Stein, D.7
Stevens, L.8
Lisanti, M.P.9
-
21
-
-
0032538790
-
Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
-
Galbiati, F., D. Volonte, J. A. Engelman, G. Watanabe, R. Burk, R. G. Pestell, and M. P. Lisanti. 1998. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 17:6633-6648.
-
(1998)
EMBO J.
, vol.17
, pp. 6633-6648
-
-
Galbiati, F.1
Volonte, D.2
Engelman, J.A.3
Watanabe, G.4
Burk, R.5
Pestell, R.G.6
Lisanti, M.P.7
-
22
-
-
0033067693
-
The Npcl mutation causes an altered expression of caveolin-I, annexin II and protein kinases and phosphorylation of caveolin-I and annexin II in murine livers
-
Garver, W. S., G. S. Hossain, M. M. Winscott, and R. A. Heidenreich. 1999. The Npcl mutation causes an altered expression of caveolin-I, annexin II and protein kinases and phosphorylation of caveolin-I and annexin II in murine livers. Biochim. Biophys. Acta 1453:193-206.
-
(1999)
Biochim. Biophys. Acta
, vol.1453
, pp. 193-206
-
-
Garver, W.S.1
Hossain, G.S.2
Winscott, M.M.3
Heidenreich, R.A.4
-
23
-
-
0029844095
-
The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3′-kinase in NIH 3T3 cells
-
Ghai, J., R. S. Ostrow, J. Tolar, R. C. McGlennen, T. D. Lemke, D. Tobolt, Z. Liu, and A. J. Faras. 1996. The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3′-kinase in NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 93:12879-12884.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 12879-12884
-
-
Ghai, J.1
Ostrow, R.S.2
Tolar, J.3
McGlennen, R.C.4
Lemke, T.D.5
Tobolt, D.6
Liu, Z.7
Faras, A.J.8
-
24
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
Giaccia, A. J., and M. B. Kastan. 1998. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12:2973-2983.
-
(1998)
Genes Dev.
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
25
-
-
0028932435
-
Association of phosphatidylinositol 3-kinase with SHC in chronic myelogcneous leukemia cells
-
Harrison-Findik, D., M. Susa, and L. Varticovski. 1995. Association of phosphatidylinositol 3-kinase with SHC in chronic myelogcneous leukemia cells. Oncogene 10:1385-1391.
-
(1995)
Oncogene
, vol.10
, pp. 1385-1391
-
-
Harrison-Findik, D.1
Susa, M.2
Varticovski, L.3
-
26
-
-
0025916387
-
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
-
Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991 The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243.
-
(1991)
Cell
, vol.66
, pp. 233-243
-
-
Itoh, N.1
Yonehara, S.2
Ishii, A.3
Yonehara, M.4
Mizushima, S.5
Sameshima, M.6
Hase, A.7
Seto, Y.8
Nagata, S.9
-
27
-
-
0032472913
-
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
-
Jimenez, C., D. R. Jones, P. Rodriguez-Viciana, A. Gonzalez-Garcia, E. Leonardo, S. Wennstrom, C. von Kobbe, J. L. Toran, L. R.-Borlado, V. Calvo, S. G. Copin, J. P. Albar, M. L. Gaspar, E. Diez, M. A. Marcos, J. Downward, C. Martinez-A, I. Merida, and A. C. Carrera. 1998. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J. 17:743-753.
-
(1998)
EMBO J.
, vol.17
, pp. 743-753
-
-
Jimenez, C.1
Jones, D.R.2
Rodriguez-Viciana, P.3
Gonzalez-Garcia, A.4
Leonardo, E.5
Wennstrom, S.6
Von Kobbe, C.7
Toran, J.L.8
R-Borlado, L.9
Calvo, V.10
Copin, S.G.11
Albar, J.P.12
Gaspar, M.L.13
Diez, E.14
Marcos, M.A.15
Downward, J.16
Martinez-A, C.17
Merida, I.18
Carrera, A.C.19
-
28
-
-
0023665111
-
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
-
Kaplan, D. R., M. Whitman, B. Schaffhausen, D. C. Pallas, M. White, L. Cantley, and T. M. Roberts. 1987. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021-1029.
-
(1987)
Cell
, vol.50
, pp. 1021-1029
-
-
Kaplan, D.R.1
Whitman, M.2
Schaffhausen, B.3
Pallas, D.C.4
White, M.5
Cantley, L.6
Roberts, T.M.7
-
29
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh, A., P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, and G. Evan. 1997, Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385:544-548.
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
30
-
-
0031459917
-
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
-
Keely, P. J., J. K. Westwick, I. P. Whitehead, C. J. Der, and L. V. Parise. 1997. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390:632-636.
-
(1997)
Nature
, vol.390
, pp. 632-636
-
-
Keely, P.J.1
Westwick, J.K.2
Whitehead, I.P.3
Der, C.J.4
Parise, L.V.5
-
31
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
Khwaja, A., P. Rodriguez-Viciana, S. Wennstrom, P. H. Warne, and J. Downward. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16:2783-2793.
-
(1997)
EMBO J.
, vol.16
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
32
-
-
0031708412
-
Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
-
Klippel, A., M. A. Escobedo, M. S. Wachowicz, G. Apell, T. W. Brown, M. A. Giedlin, W. M. Kavanaugh, and L. T. Williams. 1998. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol. Cell. Biol. 18:5699-5711.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5699-5711
-
-
Klippel, A.1
Escobedo, M.A.2
Wachowicz, M.S.3
Apell, G.4
Brown, T.W.5
Giedlin, M.A.6
Kavanaugh, W.M.7
Williams, L.T.8
-
33
-
-
0031919157
-
Regulation of ceramide production and apoptosis
-
Kolesnick, R. N., and M. Kronke. 1998. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60:643-665.
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 643-665
-
-
Kolesnick, R.N.1
Kronke, M.2
-
34
-
-
0033560896
-
Direct control of the Forkhead transcription factor AFX by protein kinase B
-
Kops, G. J., N. D. de Ruiter, A. M. De Vries-Smits, D. R. Powell, J. L. Bos, and B. M. Burgering, 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630-634.
-
(1999)
Nature
, vol.398
, pp. 630-634
-
-
Kops, G.J.1
De Ruiter, N.D.2
De Vries-Smits, A.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.6
-
35
-
-
0031034574
-
Antiapoptolic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
Kulik, G., A. Klippel, and M. J. Weber. 1997. Antiapoptolic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1595-1606.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
36
-
-
0023697978
-
Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis
-
Laster, S. M., J. G. Wood, and L. R. Gooding. 1988. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis. J. Immunol. 141: 2629-2634.
-
(1988)
J. Immunol.
, vol.141
, pp. 2629-2634
-
-
Laster, S.M.1
Wood, J.G.2
Gooding, L.R.3
-
37
-
-
0030936323
-
PTEN. a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J., C. Yen, D. Liaw, K. Podsypanina, S. Bose, S. I. Wang, J. Puc, C. Miliaresis, L. Rodgers, R. McCombie, S. H. Bigner, B. C. Giovanella, M. Ittmann, B. Tycko, H. Hibshoosh, M. H. Wigler, and R. Parsons. 1997. PTEN. a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275:1943-1947.
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
38
-
-
0028784298
-
Compartmentalized production of ceramide at the cell surface
-
Liu, P., and R. G. Anderson. 1995. Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270:27179-27185.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27179-27185
-
-
Liu, P.1
Anderson, R.G.2
-
39
-
-
0029879507
-
Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
-
Liu, P., Y. Ying, Y. G. Ko, and R. G. Anderson. 1996. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae. J. Biol. Chem. 271:10299-10303.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 10299-10303
-
-
Liu, P.1
Ying, Y.2
Ko, Y.G.3
Anderson, R.G.4
-
40
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe, S.W., H. E. Ruley, T. Jacks, and D. E. Housman. 1993. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
41
-
-
0030869787
-
Induction of vascular endothelial growth factor by hypoxia is modulated hy a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformcd cells through a hypoxia inducible factor-1 transcriptional element
-
Mazure, N. M., E. Y. Chen, K. R. Laderoute, and A. J. Giaccia. 1997. Induction of vascular endothelial growth factor by hypoxia is modulated hy a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformcd cells through a hypoxia inducible factor-1 transcriptional element. Blood 90:3322-3331.
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
Giaccia, A.J.4
-
42
-
-
0019350039
-
Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: Radiation damage in a mesenchymal system in vivo
-
Neal, J. V., and C. S. Potten. 1981. Effect of low dose ionizing radiation on the murine pericryptal fibroblast sheath: radiation damage in a mesenchymal system in vivo. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 39:175-183.
-
(1981)
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
, vol.39
, pp. 175-183
-
-
Neal, J.V.1
Potten, C.S.2
-
44
-
-
0030604280
-
Potent inhibition of angiogenesis by wortmannin, a fungal metabolite
-
Oikawa, T., and M. Shimamura. 1996. Potent inhibition of angiogenesis by wortmannin, a fungal metabolite. Eur. J. Pharmacol. 318:93-96.
-
(1996)
Eur. J. Pharmacol.
, vol.318
, pp. 93-96
-
-
Oikawa, T.1
Shimamura, M.2
-
45
-
-
0032489443
-
Caveolins. A family of scaffolding proteins for organizing "preassemhled signaling complexes" at the plasma membrane
-
Okamoto, T., A. Schlegel, P. E. Scherer, and M. P. Lisanti. 1998. Caveolins. a family of scaffolding proteins for organizing "preassemhled signaling complexes" at the plasma membrane. J. Biol. Chem. 273:5419-5422.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5419-5422
-
-
Okamoto, T.1
Schlegel, A.2
Scherer, P.E.3
Lisanti, M.P.4
-
46
-
-
0016681826
-
Epidermal apoptosis: Cell deletion by phagocytosis
-
Olson, R. L., and M. A. Everett. 1975. Epidermal apoptosis: cell deletion by phagocytosis. J. Cutan. Pathol. 2:53-57.
-
(1975)
J. Cutan. Pathol.
, vol.2
, pp. 53-57
-
-
Olson, R.L.1
Everett, M.A.2
-
47
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinosilol 3-Kinase/Akt cell survival pathway
-
Pap, M., and G. M. Cooper. 1998. Role of glycogen synthase kinase-3 in the phosphatidylinosilol 3-Kinase/Akt cell survival pathway. J. Biol. Chem. 273: 19929-19932.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
48
-
-
0032497837
-
The role of ceramide in cell signaling
-
Perry, D. K., and Y. A. Hannun. 1998. The role of ceramide in cell signaling. Biochem. Biophys. Acta 1436:233-243.
-
(1998)
Biochem. Biophys. Acta
, vol.1436
, pp. 233-243
-
-
Perry, D.K.1
Hannun, Y.A.2
-
49
-
-
0032125580
-
Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors
-
Phillips, W. A., F. St. Clair, A. D. Munday, R. J. Thomas, and C. A. Mitchell. 1998. Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors. Cancer 83:41-47.
-
(1998)
Cancer
, vol.83
, pp. 41-47
-
-
Phillips, W.A.1
St. Clair, F.2
Munday, A.D.3
Thomas, R.J.4
Mitchell, C.A.5
-
50
-
-
0032575524
-
Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover
-
Pike, L. J., and J. M. Miller. 1998. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover. J. Biol. Chem. 273:22298-22304.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22298-22304
-
-
Pike, L.J.1
Miller, J.M.2
-
51
-
-
0025602953
-
Interaction of cholesterol with various glycerophospholipids and sphingomyelin
-
Sankaram, M. B., and T. E. Thompson. 1990. Interaction of cholesterol with various glycerophospholipids and sphingomyelin. Biochemistry 29:10670-10675.
-
(1990)
Biochemistry
, vol.29
, pp. 10670-10675
-
-
Sankaram, M.B.1
Thompson, T.E.2
-
52
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphohlasts and mice are defective in radiation-induced apoptosis
-
Santana, P., L. A. Pena, A. Haimovitz-Friedman, S. Martin, D. Green, M. McLoughlin, C. Cordon-Cardo, E. H. Schuchman, Z. Fuks, and K. Kolesnick. 1996. Acid sphingomyelinase-deficient human lymphohlasts and mice are defective in radiation-induced apoptosis. Cell 86:189-199.
-
(1996)
Cell
, vol.86
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, K.10
-
53
-
-
0031765341
-
Role of plasmalemmal caveolae in signal transduction
-
Shaul, P. W., and R. G. Anderson. 1998. Role of plasmalemmal caveolae in signal transduction. Am. J. Physiol. 275:L843-L851.
-
(1998)
Am. J. Physiol.
, vol.275
-
-
Shaul, P.W.1
Anderson, R.G.2
-
54
-
-
0031456065
-
Activation of phosphoinositide 3-OH kinase by the alpha6heta4 integrin promotes carcinoma invasion
-
Shaw, L. M., I. Rabinovitz, H. H. Wang, A. Toker, and A. M. Mercurio. 1997 Activation of phosphoinositide 3-OH kinase by the alpha6heta4 integrin promotes carcinoma invasion. Cell 91:949-960.
-
(1997)
Cell
, vol.91
, pp. 949-960
-
-
Shaw, L.M.1
Rabinovitz, I.2
Wang, H.H.3
Toker, A.4
Mercurio, A.M.5
-
55
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
-
Shepherd, P. R., D. J. Withers, and K. Siddle. 1998. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem. J. 333:471-490.
-
(1998)
Biochem. J.
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
56
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh, L., Y. Lu, W. L. Kuo, R. Baldocchi, T. Godfrey, C. Collins, D. Pinkel, B. Powell, G. B. Mills, and J. W. Gray. 1999. PIK3CA is implicated as an oncogene in ovarian cancer. Nat. Genet. 21:99-102.
-
(1999)
Nat. Genet.
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
57
-
-
0030710188
-
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
-
Skorski, T., A. Bellacosa, M. Nieborowska-Skorska, M. Majewski, R. Martinez, J. K. Choi, R. Trotta, P. Wlodarski, D. Perrotti, T. O. Chan, M. A. Wasik, P. N. Tsichlis, and B. Calabretta. 1997. Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 16:6151-6161.
-
(1997)
EMBO J.
, vol.16
, pp. 6151-6161
-
-
Skorski, T.1
Bellacosa, A.2
Nieborowska-Skorska, M.3
Majewski, M.4
Martinez, R.5
Choi, J.K.6
Trotta, R.7
Wlodarski, P.8
Perrotti, D.9
Chan, T.O.10
Wasik, M.A.11
Tsichlis, P.N.12
Calabretta, B.13
-
58
-
-
0031841949
-
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
-
Summers, S. A., L. A. Garza, H. Zhou, and M. J. Birnbaum. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18:5457-5464.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5457-5464
-
-
Summers, S.A.1
Garza, L.A.2
Zhou, H.3
Birnbaum, M.J.4
-
59
-
-
0024435351
-
Phosphorylation of middle T by pp60c-src: A switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis
-
Talmage, D. A., R. Freund, A. T. Young, J. Dahl, C. J. Dawe, and T. L. Benjamin. 1989. Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell 59:55-65.
-
(1989)
Cell
, vol.59
, pp. 55-65
-
-
Talmage, D.A.1
Freund, R.2
Young, A.T.3
Dahl, J.4
Dawe, C.J.5
Benjamin, T.L.6
-
60
-
-
0031948388
-
Requirement for both She and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
-
Webster, M. A., J. N. Hutchinson, M. J. Rauh, S. K. Muthuswamy, M. Anton, C. G. Tortorice, R. O. Cardiff, F. L. Graham, J. A. Hassell, and W. J. Muller. 1998. Requirement for both She and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol. Cell. Biol. 18:2344-2359.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2344-2359
-
-
Webster, M.A.1
Hutchinson, J.N.2
Rauh, M.J.3
Muthuswamy, S.K.4
Anton, M.5
Tortorice, C.G.6
Cardiff, R.O.7
Graham, F.L.8
Hassell, J.A.9
Muller, W.J.10
-
61
-
-
0028089005
-
Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase
-
Wennstrom, S., A. Siegbahn, K. Yokote, A. K. Arvidsson, C. H. Heldin, S. Mon, and L. Claesson-Welsh. 1994. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase. Oncogene 9:651-660.
-
(1994)
Oncogene
, vol.9
, pp. 651-660
-
-
Wennstrom, S.1
Siegbahn, A.2
Yokote, K.3
Arvidsson, A.K.4
Heldin, C.H.5
Mon, S.6
Claesson-Welsh, L.7
-
62
-
-
0023425731
-
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation
-
Whitman, M., D. Kaplan, T. Roberts, and L. Cantley. 1987. Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. Biochem. J. 247:165-174.
-
(1987)
Biochem. J.
, vol.247
, pp. 165-174
-
-
Whitman, M.1
Kaplan, D.2
Roberts, T.3
Cantley, L.4
-
63
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao, R., and G. M. Cooper. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267: 2003-2006.
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
64
-
-
0032569026
-
Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
-
Zhou, H., S. A. Summers, M. J. Birnbaum, and R. N. Pittman. 1998 Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem. 273:16568-16575.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16568-16575
-
-
Zhou, H.1
Summers, S.A.2
Birnbaum, M.J.3
Pittman, R.N.4
-
65
-
-
0032128301
-
Inhibition of the anti-apoptotic PI(3)K/ Akt/Bad pathway by stress
-
Zundel, W., and A. Giaccia. 1998. Inhibition of the anti-apoptotic PI(3)K/ Akt/Bad pathway by stress. Genes Dev. 12:1941-1946.
-
(1998)
Genes Dev.
, vol.12
, pp. 1941-1946
-
-
Zundel, W.1
Giaccia, A.2
|