P53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors

Journal of Cell Biology

Volumn 143, Issue 6, 1998, Pages 1691-1703

  Aloyz, Raquel S ^a   Bamji, Shernaz X ^a   Pozniak, Christine D ^a   Toma, Jean G ^a   Atwal, Jasvinder ^a   Kaplan, David R ^a   Miller, Freda D ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Brain derived neurotrophic factor; MEKK; Nerve growth factor; Neuronal apoptosis; Sympathetic neurons

Indexed keywords

NEUROTROPHIN RECEPTOR; PROTEIN P53;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE CELL;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DEATH; CELLS, CULTURED; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASE 1; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, NEUROLOGICAL; NERVE GROWTH FACTORS; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, NERVE GROWTH FACTOR; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR; SIGNAL TRANSDUCTION; SUPERIOR CERVICAL GANGLION; TUMOR SUPPRESSOR PROTEIN P53;

ADENOVIRIDAE; ANIMALIA;

EID: 0032517786     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.143.6.1691     Document Type: Article

References (5)

1. Bamji, S.X., M. Majdan, C.D. Pozniak, D.J. Belliveau, R. Aloyz, J. Kohn, C.G. Causing, and F.D. Miller. 1998. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J. Cell Biol. 140:911-923.
2. Belliveau, D.J., I. Krivko, J. Kohn, C. Lachance, C. Pozniak, D. Rusakov, D. Kaplan, and F.D. Miller. 1997. NGF and NT-3 both activate TrkA on sympathetic neurons but differentially regulate survival and neuritogenesis. J. Cell Biol. 136:374-388.
3. Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell. 78:67-74.
4. Trink, B., K. Okami, L. Wu, V. Sriuranpong, J. Jen, and D. Sidransky. 1998. A new human p53 homologue. Nat. Med. 4:747-748.
5. Virdee, K., and A.M. Tolkovsky. 1995. Activation of p44 and p42 Map kinases is not essential for the survival of rat sympathetic neurons. Eur. J. Neurosci. 7:2159-2169.